STK38L

STK38L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PSB
Identifiers
Aliases	STK38L , NDR2, serine/threonine kinase 38 like
External IDs	OMIM: 615836; MGI: 1922250; HomoloGene: 56299; GeneCards: STK38L; OMA:STK38L - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p11.23 Start 27,243,968 bp [1] End 27,325,959 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 G3 Start 146,626,493 bp [2] End 146,680,310 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ascending aorta popliteal artery tibial arteries Achilles tendon right coronary artery Descending thoracic aorta saphenous vein left coronary artery epithelium of colon monocyte Top expressed in ascending aorta aortic valve left colon tail of embryo facial motor nucleus secondary oocyte otolith organ utricle zygote blastocyst More reference expression data BioGPS n/a
Gene ontology Molecular function kinase activity transferase activity nucleotide binding actin binding protein serine/threonine kinase activity protein kinase activity protein binding ATP binding magnesium ion binding metal ion binding Cellular component cytoplasm cytoskeleton membrane actin cytoskeleton cytosol Biological process protein phosphorylation regulation of cellular component organization intracellular signal transduction peptidyl-serine phosphorylation phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23012 232533 Ensembl ENSG00000211455 ENSMUSG00000001630 UniProt Q9Y2H1 Q7TSE6 RefSeq (mRNA) NM_015000 NM_172734 NM_001346666 RefSeq (protein) NP_055815 NP_001333595 NP_766322 Location (UCSC) Chr 12: 27.24 – 27.33 Mb Chr 6: 146.63 – 146.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase 38-like is an enzyme that in humans is encoded by the STK38L gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000211455 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001630 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Suzuki A, Ogura T, Esumi H (May 2006). "NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling". J Biol Chem. 281 (20): 13915–21. doi: 10.1074/jbc.M511354200 . PMID   16488889.
6. "Entrez Gene: STK38L serine/threonine kinase 38 like".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi: 10.1093/dnares/6.1.63 . PMID   10231032.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Stegert MR, Tamaskovic R, Bichsel SJ, et al. (2004). "Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein". J. Biol. Chem. 279 (22): 23806–12. doi: 10.1074/jbc.M402472200 . PMID   15037617.
• Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444–51. doi: 10.1074/jbc.M401999200 . PMID   15067004.
• Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (2005). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein". J. Biol. Chem. 279 (34): 35228–35. doi: 10.1074/jbc.M404542200 . PMID   15197186.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Devroe E, Silver PA, Engelman A (2005). "HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases". Virology. 331 (1): 181–9. doi:10.1016/j.virol.2004.10.023. PMID   15582665.
• Stegert MR, Hergovich A, Tamaskovic R, et al. (2006). "Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3". Mol. Cell. Biol. 25 (24): 11019–29. doi:10.1128/MCB.25.24.11019-11029.2005. PMC   1316964 . PMID   16314523.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.