MAST1

MAST1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M9X, 3PS4
Identifiers
Aliases	MAST1 , SAST, SAST170, microtubule associated serine/threonine kinase 1, MCCCHCM
External IDs	OMIM: 612256 MGI: 1861901 HomoloGene: 10543 GeneCards: MAST1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,874,952 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,663,988 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Brodmann area 9; ; prefrontal cortex; ; frontal pole; ; Brodmann area 10; ; anterior pituitary; ; hypothalamus; ; amygdala; ; hippocampus proper; ; superior frontal gyrus;
	Top expressed in
	motor neuron; ; cerebellar cortex; ; superior colliculus; ; pontine nuclei; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; dorsal tegmental nucleus; ; cerebellar vermis; ; medial dorsal nucleus; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein kinase activity ; protein serine/threonine kinase activity ; protein binding ; ATP binding ; magnesium ion binding ; metal ion binding ; kinase activity ;
Cellular component	cytoplasm ; plasma membrane ; intracellular anatomical structure ; cytoskeleton ; membrane ;
Biological process	protein phosphorylation ; intracellular signal transduction ; cytoskeleton organization ; peptidyl-serine phosphorylation ; phosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	22983
	56527
	ENSG00000105613
	ENSMUSG00000053693
	Q9Y2H9
	Q9R1L5
	NM_014975
	NM_019945
	NP_055790
	NP_064329
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 30, 2022

Microtubule-associated serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MAST1 gene.^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105613 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053693 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MAST1 microtubule associated serine/threonine kinase 1".

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID 15057824.
Yano R, Yap CC, Yamazaki Y, et al. (2003). "Sast124, a novel splice variant of syntrophin-associated serine/threonine kinase (SAST), is specifically localized in the restricted brain regions". Neuroscience. 117 (2): 373–81. doi:10.1016/S0306-4522(02)00785-6. PMID 12614677. S2CID 125224.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184. S2CID 826987.
Lumeng C, Phelps S, Crawford GE, et al. (1999). "Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases". Nat. Neurosci. 2 (7): 611–7. doi:10.1038/10165. PMID 10404183. S2CID 20910888.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi: 10.1093/dnares/6.1.63 . PMID 10231032.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105613 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053693 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MAST1 microtubule associated serine/threonine kinase 1".

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

MAST1

Related Research Articles

References

Further reading