MARK2

MARK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IEC, 5EAK
Identifiers
Aliases	MARK2 , EMK-1, EMK1, PAR-1, Par-1b, Par1b, microtubule affinity regulating kinase 2
External IDs	OMIM: 600526 MGI: 99638 HomoloGene: 69013 GeneCards: MARK2
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q13.1 Start 63,838,928 bp [1] End 63,911,020 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19 A|19 5.32 cM Start 7,252,761 bp [2] End 7,319,225 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen monocyte rectum minor salivary gland islet of Langerhans right lobe of thyroid gland body of pancreas right uterine tube sural nerve anterior pituitary Top expressed in corneal stroma superior surface of tongue plantaris muscle secondary oocyte extensor digitorum longus muscle spermatocyte lacrimal gland entorhinal cortex lip cingulate gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein kinase activator activity metal ion binding kinase activity protein serine/threonine kinase activity tau-protein kinase activity protein binding ATP binding magnesium ion binding lipid binding RNA binding cadherin binding tau protein binding Cellular component microtubule bundle cytoplasm lateral plasma membrane membrane plasma membrane mitochondrion actin filament cytoskeleton nucleoplasm dendrite cell projection Biological process cell differentiation intracellular signal transduction phosphorylation mitochondrion localization neuron migration Wnt signaling pathway regulation of axonogenesis multicellular organism development protein phosphorylation autophagy of mitochondrion establishment or maintenance of epithelial cell apical/basal polarity positive regulation of neuron projection development protein autophosphorylation peptidyl-threonine phosphorylation activation of protein kinase activity regulation of cytoskeleton organization establishment of cell polarity microtubule cytoskeleton organization peptidyl-serine phosphorylation axon development regulation of microtubule cytoskeleton organization establishment or maintenance of cell polarity regulating cell shape regulation of microtubule binding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2011 13728 Ensembl ENSG00000072518 ENSMUSG00000024969 UniProt Q7KZI7 Q05512 RefSeq (mRNA) NM_001039469 NM_001163296 NM_001163297 NM_004954 NM_017490 NM_001080388 NM_001080389 NM_001080390 NM_007928 RefSeq (protein) NP_001034558 NP_001156768 NP_001156769 NP_004945 NP_059672 NP_001073857 NP_001073858 NP_001073859 NP_031954 Location (UCSC) Chr 11: 63.84 – 63.91 Mb Chr 19: 7.25 – 7.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the MARK2 gene. ^{[5] [6] [7]}

Function

EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed. ^[7]

Interactions

MARK2 has been shown to interact with AKT1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000072518 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024969 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Espinosa L, Navarro E (Oct 1998). "Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing". Cytogenet Cell Genet. 81 (3–4): 278–82. doi:10.1159/000015046. PMID   9730619. S2CID   46869824.
6. Navarro E (Oct 1999). "Precise localization of D11S1226 to the human EMK1 gene at chromosome band 11q13 by sequence homology search". Cytogenet Cell Genet. 86 (1): 66–7. doi:10.1159/000015413. PMID   10516437. S2CID   26642331.
7. "Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2".
8. Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, Monks B, Sun M, Cheng JQ, Patterson C, Bailey RM, Dunmore J, Soresh S, Leon C, Morgan D, Petrucelli L (Mar 2008). "Akt and CHIP coregulate tau degradation through coordinated interactions". Proc. Natl. Acad. Sci. U.S.A. 105 (9): 3622–7. Bibcode:2008PNAS..105.3622D. doi: 10.1073/pnas.0709180105 . PMC   2265134 . PMID   18292230.

Further reading

• Courseaux A, Fernandes M, Grosgeorge J, Inglis J, Raynaud SD, Gaudray P (1995). "Human EMK1 is located on 11q12-q13, close to COX8 and FTH1". Mamm. Genome. 6 (4): 311–2. doi:10.1007/BF00352433. PMID   7613050. S2CID   37616665.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID   8274451.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Courseaux A, Grosgeorge J, Gaudray P, Pannett AA, Forbes SA, Williamson C, Bassett D, Thakker RV, Teh BT, Farnebo F, Shepherd J, Skogseid B, Larsson C, Giraud S, Zhang CX, Salandre J, Calender A (1997). "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1)". Genomics. 37 (3): 354–65. doi:10.1006/geno.1996.0570. PMID   8938448.
• Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell. 89 (2): 297–308. doi: 10.1016/S0092-8674(00)80208-1 . PMID   9108484. S2CID   15647848.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT (2001). "PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling". Nat. Cell Biol. 3 (7): 628–36. doi:10.1038/35083016. PMID   11433294. S2CID   1128604.
• Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi: 10.1074/jbc.M312171200 . PMID   14676191.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC   381014 . PMID   14976552.
• Hueso M, Beltran V, Moreso F, Ciriero E, Fulladosa X, Grinyó JM, Serón D, Navarro E (2004). "Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of transplanted patients". Biochim. Biophys. Acta. 1689 (1): 58–65. doi:10.1016/j.bbadis.2004.01.008. PMID   15158914.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Suzuki A, Hirata M, Kamimura K, Maniwa R, Yamanaka T, Mizuno K, Kishikawa M, Hirose H, Amano Y, Izumi N, Miwa Y, Ohno S (2004). "aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity". Curr. Biol. 14 (16): 1425–35. doi: 10.1016/j.cub.2004.08.021 . PMID   15324659. S2CID   293494.
• Cohen D, Rodriguez-Boulan E, Müsch A (2004). "Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13792–7. Bibcode:2004PNAS..10113792C. doi: 10.1073/pnas.0403684101 . PMC   518835 . PMID   15365179.
• Hazarika P, McCarty MF, Prieto VG, George S, Babu D, Koul D, Bar-Eli M, Duvic M (2004). "Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1". Cancer Res. 64 (20): 7361–9. doi: 10.1158/0008-5472.CAN-04-0823 . PMID   15492257.