PCTK1

Last updated
CDK16
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CDK16 , PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1, cyclin-dependent kinase 16, cyclin dependent kinase 16
External IDs OMIM: 311550; MGI: 97516; HomoloGene: 7878; GeneCards: CDK16; OMA:CDK16 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001170460
NM_006201
NM_033018
NM_033019

NM_011049
NM_001310456

RefSeq (protein)

NP_001163931
NP_006192
NP_148978

NP_001297385
NP_035179

Location (UCSC) Chr X: 47.22 – 47.23 Mb Chr X: 20.55 – 20.57 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase PCTAIRE-1 is an enzyme that in humans is encoded by the CDK16 gene. [5] [6]

Contents

Function

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells. This gene is thought to escape X inactivation. Two transcript variants encoding the same protein have been found for this gene. [6]

Interactions

PCTK1 has been shown to interact with CDK5R1. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000102225 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031065 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249–58. PMID   1437147.
  6. 1 2 "Entrez Gene: PCTK1 PCTAIRE protein kinase 1".
  7. Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY (Aug 2002). "Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35". J. Biol. Chem. 277 (35): 31988–93. doi: 10.1074/jbc.M201161200 . PMID   12084709.

Further reading