RPS6KA5

Last updated

RPS6KA5
Protein RPS6KA5 PDB 1vzo.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RPS6KA5 , MSK1, MSPK1, RLPK, ribosomal protein S6 kinase A5
External IDs OMIM: 603607; MGI: 1920336; HomoloGene: 48302; GeneCards: RPS6KA5; OMA:RPS6KA5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153587
NM_001330702

RefSeq (protein)

NP_001317631
NP_705815

Location (UCSC) Chr 14: 90.85 – 91.06 Mb Chr 12: 100.51 – 100.69 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene. [5] [6] [7] This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes. [8] [9]

Interactions

RPS6KA5 has been shown to interact with CREB1. [5] [10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100784 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021180 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Deak M, Clifton AD, Lucocq LM, Alessi DR (September 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". The EMBO Journal. 17 (15): 4426–4441. doi:10.1093/emboj/17.15.4426. PMC   1170775 . PMID   9687510.
  6. Jiang C, Yu L, Tu Q, Zhao Y, Zhang H, Zhao S (April 2000). "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31→q32.1 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 87 (3–4): 261–262. doi:10.1159/000015441. PMID   10702687. S2CID   10527498.
  7. "Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5".
  8. Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, et al. (2003-06-02). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". The EMBO Journal. 22 (11): 2788–2797. doi:10.1093/emboj/cdg273. ISSN   0261-4189. PMC   156769 . PMID   12773393.
  9. Reul JM, Chandramohan Y (2007-08-01). "Epigenetic mechanisms in stress-related memory formation" . Psychoneuroendocrinology. Integrative approaches to neural plasticity (Lille Summer School, 2006). 32 Suppl 1: S21 –S25. doi:10.1016/j.psyneuen.2007.03.016. ISSN   0306-4530. PMID   17644269. S2CID   24217924.
  10. Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG (August 2001). "Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase". The EMBO Journal. 20 (16): 4370–4379. doi:10.1093/emboj/20.16.4370. ISSN   0261-4189. PMC   125559 . PMID   11500364.

Further reading