PCTK3

CDK18
Identifiers
Aliases	CDK18 , PCTAIRE, PCTAIRE3, PCTK3, cyclin-dependent kinase 18, cyclin dependent kinase 18
External IDs	OMIM: 169190; MGI: 97518; HomoloGene: 1949; GeneCards: CDK18; OMA:CDK18 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 205,504,596 bp [1] End 205,532,793 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 132,039,975 bp [2] End 132,067,422 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment inferior ganglion of vagus nerve apex of heart middle frontal gyrus subthalamic nucleus right auricle of heart corpus callosum pars reticulata left ventricle ventral tegmental area Top expressed in duodenum molar right kidney jejunum pontine nuclei lumbar subsegment of spinal cord epithelium of stomach transitional epithelium of urinary bladder intestinal villus dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein binding ATP binding kinase activity cyclin-dependent protein serine/threonine kinase activity protein serine/threonine kinase activity Cellular component nucleus cytoplasm cellular component Biological process phosphorylation protein phosphorylation regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5129 18557 Ensembl ENSG00000117266 ENSMUSG00000026437 UniProt Q07002 Q04899 RefSeq (mRNA) NM_002596 NM_212502 NM_212503 NM_008795 RefSeq (protein) NP_002587 NP_997667 NP_997668 NP_032821 Location (UCSC) Chr 1: 205.5 – 205.53 Mb Chr 1: 132.04 – 132.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase PCTAIRE-3 is an enzyme that in humans is encoded by the CDK18 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000117266 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026437 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249–58. PMID   1437147.
6. "Entrez Gene: PCTK3 PCTAIRE protein kinase 3".

Further reading

• Meyerson M, Enders GH, Wu CL, et al. (1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. doi:10.1002/j.1460-2075.1992.tb05360.x. PMC   556772 . PMID   1639063.
• Okuda T, Valentine VA, Shapiro DN, Downing JR (1994). "Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes". Genomics. 21 (1): 217–21. doi:10.1006/geno.1994.1245. PMID   8088790.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Herskovits AZ, Davies P (2004). "Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain". Gene. 328: 59–67. doi:10.1016/j.gene.2003.12.011. PMID   15019984.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport". J. Cell Sci. 118 (Pt 17): 3839–47. doi: 10.1242/jcs.02496 . PMID   16091426.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Herskovits AZ, Davies P (2006). "The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease". Neurobiol. Dis. 23 (2): 398–408. doi:10.1016/j.nbd.2006.04.004. PMID   16766195. S2CID   39038607.
• Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi: 10.1074/mcp.T600062-MCP200 . hdl: 10033/19756 . PMID   17192257.