PCTK3

CDK18
Identifiers
Aliases	CDK18 , PCTAIRE, PCTAIRE3, PCTK3, cyclin-dependent kinase 18, cyclin dependent kinase 18
External IDs	OMIM: 169190 MGI: 97518 HomoloGene: 1949 GeneCards: CDK18
Gene location (Human)
Chr.	Chromosome 1 (human)
End	205,532,793 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	132,067,422 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; middle frontal gyrus; ; subthalamic nucleus; ; corpus callosum; ; left ventricle; ; ventral tegmental area; ; superior vestibular nucleus; ; pons; ; external globus pallidus; ; amygdala;
	Top expressed in
	duodenum; ; molar; ; jejunum; ; pontine nuclei; ; epithelium of stomach; ; intestinal villus; ; dorsomedial hypothalamic nucleus; ; ileum; ; ventral tegmental area; ; lacrimal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein kinase activity ; protein binding ; ATP binding ; kinase activity ; cyclin-dependent protein serine/threonine kinase activity ; protein serine/threonine kinase activity ;
Cellular component	nucleus ; cytoplasm ; cellular component ;
Biological process	phosphorylation ; protein phosphorylation ; regulation of cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	5129
	18557
	ENSG00000117266
	ENSMUSG00000026437
	Q07002
	Q04899
	NM_002596 ; NM_212502 ; NM_212503
	NM_008795
	NP_002587 ; NP_997667 ; NP_997668
	NP_032821
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated February 15, 2024

Serine/threonine-protein kinase PCTAIRE-3 is an enzyme that in humans is encoded by the CDK18 gene.^[5]^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117266 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026437 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249–58. PMID 1437147.
↑ "Entrez Gene: PCTK3 PCTAIRE protein kinase 3".

Meyerson M, Enders GH, Wu CL, et al. (1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. doi:10.1002/j.1460-2075.1992.tb05360.x. PMC 556772 . PMID 1639063.
Okuda T, Valentine VA, Shapiro DN, Downing JR (1994). "Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes". Genomics. 21 (1): 217–21. doi:10.1006/geno.1994.1245. PMID 8088790.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Herskovits AZ, Davies P (2004). "Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain". Gene. 328: 59–67. doi:10.1016/j.gene.2003.12.011. PMID 15019984.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport". J. Cell Sci. 118 (Pt 17): 3839–47. doi: 10.1242/jcs.02496 . PMID 16091426.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.
Herskovits AZ, Davies P (2006). "The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease". Neurobiol. Dis. 23 (2): 398–408. doi:10.1016/j.nbd.2006.04.004. PMID 16766195. S2CID 39038607.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi: 10.1074/mcp.T600062-MCP200 . hdl: 10033/19756 . PMID 17192257.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000117266 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026437 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1437147-5] Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249–58. PMID 1437147.

[entrez-6] "Entrez Gene: PCTK3 PCTAIRE protein kinase 3".

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

PCTK3

Related Research Articles

References

Further reading