Dual-specificity kinase

Dual-specificity kinase
Identifiers
EC no.	2.7.12.1
CAS no.	134549-83-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In biochemistry, a dual-specificity kinase (EC 2.7.12.1) is a kinase that can act as both tyrosine kinase and serine/threonine kinase.

MEKs, involved in MAP pathways, are principal examples of dual-specificity kinases. Other common examples include:

• ADK1 (Arabidopsis dual specificity kinase 1)
• CLK1, CLK2, CLK3, CLK4
• DSTYK
• DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4
• Mps1p
• TESK1, TESK2
• TTK

The systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating).

References

• Dhanasekaran N, Premkumar Reddy E (1998). "Signaling by dual specificity kinases". Oncogene. 17 (11 Reviews): 1447–1455. doi: 10.1038/sj.onc.1202251 . PMID   9779990.
• Ali N, Halfter U, Chua NH (1994). "Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine". J. Biol. Chem. 269 (50): 31626–9. doi: 10.1016/S0021-9258(18)31740-X . PMID   7527390.
• Lauze E, Stoelcker B, Luca FC, Weiss E, Schutz AR, Winey M (1995). "Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase". EMBO J. 14 (8): 1655–63. doi:10.1002/j.1460-2075.1995.tb07154.x. PMC   398258 . PMID   7737118.
• Menegay HJ, Myers MP, Moeslein FM, Landreth GE (2000). "Biochemical characterization and localization of the dual specificity kinase CLK1". J. Cell Sci. 113 (18): 3241–53. doi:10.1242/jcs.113.18.3241. PMID   10954422.
• Cleghon V; Sibbet, G; Kinstrie, R; Cleghon, T; Rylatt, M; Morrison, DK; Cleghon, V (2003). "dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila". Biochem. J. 374 (Pt 2): 381–91. doi:10.1042/BJ20030500. PMC   1223608 . PMID   12786602.