Protein-histidine pros-kinase

Last updated
protein histidine pros-kinase
Identifiers
EC no. 2.7.13.1
CAS no. 99283-67-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, a protein-histidine pros-kinase (EC 2.7.13.1) is an enzyme that catalyzes the chemical reaction

ATP + protein L-histidine ADP + protein Nπ-phospho-L-histidine

Thus, the two substrates of this enzyme are ATP and protein L-histidine, whereas its two products are ADP and protein Npi-phospho-L-histidine.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain of histidine residues in proteins (protein-histidine kinases). The systematic name of this enzyme class is ATP:protein-L-histidine Npi-phosphotransferase. Other names in common use include ATP:protein-L-histidine N-pros-phosphotransferase, histidine kinase, histidine protein kinase, protein histidine kinase, protein kinase (histidine), and HK2.

Related Research Articles

In enzymology, arginine kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a beta-adrenergic-receptor kinase is an enzyme that catalyzes the chemical reaction:

In enzymology, a beta-glucoside kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a dephospho-[reductase kinase] kinase is an enzyme that catalyzes the chemical reaction

In enzymology, an elongation factor 2 kinase is an enzyme that catalyzes the chemical reaction:

In enzymology, a galacturonokinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Gluconokinase</span>

In enzymology, a gluconokinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Guanylate kinase</span>

In enzymology, a guanylate kinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Histidine kinase</span>

Histidine kinases (HK) are multifunctional, and in non-animal kingdoms, typically transmembrane, proteins of the transferase class of enzymes that play a role in signal transduction across the cellular membrane. The vast majority of HKs are homodimers that exhibit autokinase, phosphotransfer, and phosphatase activity. HKs can act as cellular receptors for signaling molecules in a way analogous to tyrosine kinase receptors (RTK). Multifunctional receptor molecules such as HKs and RTKs typically have portions on the outside of the cell that bind to hormone- or growth factor-like molecules, portions that span the cell membrane, and portions within the cell that contain the enzymatic activity. In addition to kinase activity, the intracellular domains typically have regions that bind to a secondary effector molecule or complex of molecules that further propagate signal transduction within the cell. Distinct from other classes of protein kinases, HKs are usually parts of a two-component signal transduction mechanisms in which HK transfers a phosphate group from ATP to a histidine residue within the kinase, and then to an aspartate residue on the receiver domain of a response regulator protein. More recently, the widespread existence of protein histidine phosphorylation distinct from that of two-component histidine kinases has been recognised in human cells. In marked contrast to Ser, Thr and Tyr phosphorylation, the analysis of phosphorylated Histidine using standard biochemical and mass spectrometric approaches is much more challenging, and special procedures and separation techniques are required for their preservation alongside classical Ser, Thr and Tyr phosphorylation on proteins isolated from human cells.

<span class="mw-page-title-main">Homoserine kinase</span> Enzyme

In enzymology, a homoserine kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a low-density-lipoprotein receptor kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a phosphoenolpyruvate-protein phosphotransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a polo kinase is a kinase enzyme i.e. one that catalyzes the chemical reaction

In enzymology, a polynucleotide 5'-hydroxyl-kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a protein-histidine tele-kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a protein-Npi-phosphohistidine-sugar phosphotransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an [RNA-polymerase]-subunit kinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Tau-protein kinase</span> Class of enzymes

In enzymology, a tau-protein kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a tropomyosin kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a [tyrosine 3-monooxygenase] kinase is an enzyme that catalyzes the chemical reaction

References


    This page is based on this Wikipedia article
    Text is available under the CC BY-SA 4.0 license; additional terms may apply.
    Images, videos and audio are available under their respective licenses.