REV3L

Last updated
REV3L
Protein MAD2L2 PDB 3ABD.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases REV3L , POLZ, REV3, REV3 like, DNA directed polymerase zeta catalytic subunit
External IDs OMIM: 602776 MGI: 1337131 HomoloGene: 48147 GeneCards: REV3L
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286431
NM_001286432
NM_002912
NM_001372078

NM_011264

RefSeq (protein)

NP_001273360
NP_001273361
NP_002903
NP_001359007

NP_035394

Location (UCSC) Chr 6: 111.3 – 111.48 Mb Chr 10: 39.61 – 39.75 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein reversionless 3-like (REV3L) also known as DNA polymerase zeta catalytic subunit (POLZ) is an enzyme that in humans is encoded by the REV3L gene. [5] [6] [7]

Contents

The Rev3 subunit interacts with Rev7 to form Pol ζ, a B family polymerase. Pol ζ lacks 3' to 5' exonuclease activity and is a moderate fidelity polymerase. It cannot add nucleotides across from DNA lesions, yet it can extend from primers with terminal mismatches. This makes Pol ζ very important in translesion synthesis (TLS), because it can act in concert with other TLS polymerases that can add across the lesion to complete the bypass of the lesion. Most polymerases have difficulty extending mismatches because they cannot bind properly to the mismatched DNA. So rather than the cell dying, it can survive albeit with a mutation that may or may not be deleterious, so it is believed that Pol ζ is a driving force of evolution.[ citation needed ]

Interactions

REV3L has been shown to interact with MAD2L2. [8] [9]

Related Research Articles

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<span class="mw-page-title-main">DNA repair</span> Cellular mechanism

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<span class="mw-page-title-main">POLI</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">POLK</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PRIM2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">DNA polymerase eta</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">RNASEH2B</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PrimPol</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">DNA polymerase alpha catalytic subunit</span> Protein-coding gene in humans

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<span class="mw-page-title-main">Deepak T. Nair</span>

Deepak Thankappan Nair is an Indian Structural Biologist and a scientist at Regional Centre for Biotechnology. He is known for his studies on DNA and RNA polymerases. Deepak was a Ramanujan fellow of the Science and Engineering Research Board (2008–2013) and a recipient of the National BioScience Award for Career Development. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, for his contributions to biological sciences in 2017.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000009413 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019841 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gibbs PE, McGregor WG, Maher VM, Nisson P, Lawrence CW (Jul 1998). "A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta". Proc Natl Acad Sci U S A. 95 (12): 6876–80. Bibcode:1998PNAS...95.6876G. doi: 10.1073/pnas.95.12.6876 . PMC   22668 . PMID   9618506.
  6. Morelli C, Mungall AJ, Negrini M, Barbanti-Brodano G, Croce CM (Mar 1999). "Alternative splicing, genomic structure, and fine chromosome localization of REV3L". Cytogenet Cell Genet. 83 (1–2): 18–20. doi:10.1159/000015157. PMID   9925914. S2CID   45239336.
  7. "Entrez Gene: REV3L REV3-like, catalytic subunit of DNA polymerase zeta (yeast)".
  8. Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R (February 2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. 275 (6): 4391–7. doi: 10.1074/jbc.275.6.4391 . PMID   10660610.
  9. Murakumo Y, Ogura Y, Ishii H, Numata S, Ichihara M, Croce CM, Fishel R, Takahashi M (September 2001). "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7". J. Biol. Chem. 276 (38): 35644–51. doi: 10.1074/jbc.M102051200 . PMID   11485998.

Further reading