DNA polymerase nu

Last updated
POLN
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases POLN , POL4P, polymerase (DNA) nu, DNA polymerase nu
External IDs OMIM: 610887; MGI: 2675617; HomoloGene: 129696; GeneCards: POLN; OMA:POLN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181808

NM_001289803
NM_001289804
NM_181857

RefSeq (protein)

NP_861524

NP_001276732
NP_001276733
NP_862905

Location (UCSC) Chr 4: 2.07 – 2.24 Mb Chr 5: 34.16 – 34.33 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Polymerase (DNA directed) nu is a protein in humans that is encoded by the POLN gene. [5] It is a family A DNA polymerase, [6] considered to be the least effective of the polymerase enzymes. [7] However, DNA polymerase nu plays an active role in homology repair during cellular responses to crosslinks, fulfilling its role in a complex with helicase. [7]

Contents

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000130997 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045102 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Polymerase (DNA directed) nu".
  6. Marini F, Kim N, Schuffert A, Wood RD (August 2003). "POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308". The Journal of Biological Chemistry. 278 (34): 32014–9. doi: 10.1074/jbc.M305646200 . PMID   12794064.
  7. 1 2 "UniProtKB - Q7Z5Q5 (DPOLN_HUMAN)". Uniprot. Retrieved 5 July 2018.

Further reading