GSK3A

GSK3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DFM
Identifiers
Aliases	GSK3A , Gsk3a, 2700086H06Rik, glycogen synthase kinase 3 alpha
External IDs	OMIM: 606784 MGI: 2152453 HomoloGene: 88581 GeneCards: GSK3A
EC number	2.7.11.1
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.2 Start 42,226,225 bp [1] End 42,242,625 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A3 Start 24,927,683 bp [2] End 24,937,276 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence prefrontal cortex cingulate gyrus amygdala anterior pituitary Brodmann area 9 nucleus accumbens stromal cell of endometrium right lobe of thyroid gland putamen Top expressed in motor neuron primary motor cortex superior colliculus subiculum piriform cortex cingulate gyrus pontine nuclei dorsal tegmental nucleus globus pallidus olfactory tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein serine/threonine kinase activity tau-protein kinase activity protein binding ATP binding protein kinase binding protein kinase A catalytic subunit binding signaling receptor binding tau protein binding Cellular component cytosol beta-catenin destruction complex postsynapse mitochondrion cytoplasm microtubule neuronal cell body apical dendrite proximal dendrite Biological process positive regulation of protein catabolic process phosphorylation positive regulation of protein targeting to mitochondrion chemical synaptic transmission, postsynaptic negative regulation of UDP-glucose catabolic process negative regulation of type B pancreatic cell development Wnt signaling pathway negative regulation of glycogen biosynthetic process nervous system development negative regulation of glycogen synthase activity, transferring glucose-1-phosphate dopamine receptor signaling pathway protein phosphorylation IRE1-mediated unfolded protein response negative regulation of glucose import negative regulation of insulin receptor signaling pathway regulation of autophagy of mitochondrion negative regulation of glycogen (starch) synthase activity cellular response to insulin stimulus glycogen metabolic process negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of systemic arterial blood pressure cardiac left ventricle morphogenesis regulation of gene expression by genetic imprinting human ageing insulin receptor signaling pathway positive regulation of peptidyl-threonine phosphorylation cell migration negative regulation of TOR signaling positive regulation of peptidyl-serine phosphorylation cellular response to interleukin-3 proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of neuron apoptotic process hypermethylation of CpG island positive regulation of heart contraction positive regulation of transcription by RNA polymerase II negative regulation of cell growth involved in cardiac muscle cell development cellular response to lithium ion cellular response to organic cyclic compound positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway extrinsic apoptotic signaling pathway in absence of ligand positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway negative regulation of dendrite development positive regulation of glycogen (starch) synthase activity carbohydrate metabolic process positive regulation of gene expression peptidyl-threonine phosphorylation positive regulation of protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process excitatory postsynaptic potential extrinsic apoptotic signaling pathway positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of amyloid-beta formation positive regulation of autophagy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2931 606496 Ensembl ENSG00000105723 ENSMUSG00000057177 UniProt P49840 Q2NL51 RefSeq (mRNA) NM_019884 NM_001031667 RefSeq (protein) NP_063937 NP_001026837 Location (UCSC) Chr 19: 42.23 – 42.24 Mb Chr 7: 24.93 – 24.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene. ^[5]

Glycogen synthase kinase 3-alpha EC 2.7.1.37 is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and various transcription factors (e.g., JUN). It also plays a role in the WNT and phosphoinositide 3-kinase (especially PIK3CG) signaling pathways. ^{[6] [7]}

Model organisms

Gsk3a knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Normal
Homozygous Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Skin Histopathology	Normal
All tests and analysis from [8] [9]

Model organisms have been used in the study of GSK3A function. A conditional knockout mouse line, called Gsk3a^{tm1a(EUCOMM)Wtsi [10] [11]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. ^{[12] [13] [14]}

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. ^{[8] [15]} Twenty one tests were carried out on mutant mice but no significant abnormalities were observed. ^[8]

See also

• Glycogen synthase kinase 3

References

1. GRCh38: Ensembl release 89: ENSG00000105723 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057177 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shaw PC, Davies AF, Lau KF, Garcia-Barcelo M, Waye MM, Lovestone S, Miller CC, Anderton BH (Oct 1998). "Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes". Genome. 41 (5): 720–7. doi:10.1139/gen-41-5-720. PMID   9809441.
6. Ali A, Hoeflich KP, Woodgett JR (Aug 2001). "Glycogen synthase kinase-3: properties, functions, and regulation". Chemical Reviews. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID   11749387.
7. "Entrez Gene: GSK3A glycogen synthase kinase 3 alpha".
8. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID   85911512.
9. Mouse Resources Portal, Wellcome Trust Sanger Institute.
10. "International Knockout Mouse Consortium".
11. "Mouse Genome Informatics".
12. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC   3572410 . PMID   21677750.
13. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi: 10.1038/474262a . PMID   21677718.
14. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi: 10.1016/j.cell.2006.12.018 . PMID   17218247. S2CID   18872015.
15. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi: 10.1186/gb-2011-12-6-224 . PMC   3218837 . PMID   21722353.