TSSK2

TSSK2
Identifiers
Aliases	TSSK2 , DGS-G, SPOGA2, STK22B, TSK2, testis specific serine kinase 2
External IDs	OMIM: 610710 MGI: 1347559 HomoloGene: 31512 GeneCards: TSSK2
Gene location (Human)
Chr.	Chromosome 22 (human)
End	19,132,622 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	17,717,888 bp
RNA expression pattern
	Top expressed in
	sperm; ; tibialis anterior muscle; ; ganglionic eminence; ; deltoid muscle; ; trachea; ; gastrocnemius muscle; ; blood; ; appendix; ; prefrontal cortex; ; myometrium;
	Top expressed in
	spermatid; ; testicle; ; spermatocyte; ; secondary oocyte; ; islet of Langerhans; ; skeletal muscle tissue; ; urinary bladder; ; bone marrow; ; embryo; ; liver;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein kinase activity ; metal ion binding ; kinase activity ; protein serine/threonine kinase activity ; protein binding ; ATP binding ; magnesium ion binding ; protein-containing complex binding ;
Cellular component	cytoplasm ; acrosomal vesicle ; centriole ; cytoskeleton ; nucleus ;
Biological process	cell differentiation ; intracellular signal transduction ; phosphorylation ; multicellular organism development ; protein phosphorylation ; spermatogenesis ; spermatid development ; protein autophosphorylation ; peptidyl-serine phosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	23617
	22115
	ENSG00000206203
	ENSMUSG00000045521
	Q96PF2
	O54863
	NM_053006
	NM_009436
	NP_443732
	NP_033462
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 29, 2023

Testis-specific serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the TSSK2 gene.^[5]^[6]

Related Research Articles

LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene.

Probable ATP-dependent RNA helicase DDX17 (p72) is an enzyme that in humans is encoded by the DDX17 gene.

SEC14L2 is a gene that, in humans, encodes the protein SEC14-like protein 2.

60S ribosomal protein L3 is a protein that in humans is encoded by the RPL3 gene.

Protein kinase C and casein kinase substrate in neurons protein 2 is a protein that in humans is encoded by the PACSIN2 gene. Pacsin 2 is involved in the formation of caveolae.

Peroxisomal membrane protein PMP34 is a protein that in humans is encoded by the SLC25A17 gene.

Phosphatidylserine decarboxylase proenzyme is an enzyme that in humans is encoded by the PISD gene.

Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.

Zinc finger protein 74 is a protein that in humans is encoded by the ZNF74 gene. Schizophrenia susceptibility has been associated with a mutation in this protein.

Lethal(3)malignant brain tumor-like 2 protein is a protein that in humans is encoded by the L3MBTL2 gene.

SH3 domain-binding protein 1 is a protein that in humans is encoded by the SH3BP1 gene.

Glycosyltransferase-like protein LARGE1 is an enzyme that in humans is encoded by the LARGE gene.

Probable tubulin polyglutamylase TTLL1 is an enzyme that in humans is encoded by the TTLL1 gene.

Protein Tob2 is a protein that in humans is encoded by the TOB2 gene.

Peptidyl-prolyl cis-trans isomerase-like 2 is an enzyme that in humans is encoded by the PPIL2 gene.

Patatin-like phospholipase domain-containing protein 3 (PNPLA3) also known as adiponutrin (ADPN), acylglycerol O-acyltransferase or calcium-independent phospholipase A2-epsilon (iPLA2-epsilon) is an enzyme that in humans is encoded by the PNPLA3 gene.

Dynein light chain 4, axonemal is a protein that in humans is encoded by the DNAL4 gene.

Transmembrane protein 184B is a protein that in humans is encoded by the TMEM184B gene.

Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.

Ras-related protein Rab-36 is a protein that in humans is encoded by the RAB36 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000206203 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045521 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
↑ "Entrez Gene: TSSK2 testis-specific serine kinase 2".

Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC 545604 . PMID 15461802.
Hao Z, Jha KN, Kim YH, Vemuganti S, Westbrook VA, Chertihin O, Markgraf K, Flickinger CJ, Coppola M, Herr JC, Visconti PE (2005). "Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm". Mol. Hum. Reprod. 10 (6): 433–444. doi: 10.1093/molehr/gah052 . PMID 15044604.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–1765. doi:10.1101/gr.180101. PMC 311163 . PMID 11591653.
Kueng P, Nikolova Z, Djonov V, Hemphill A, Rohrbach V, Boehlen D, Zuercher G, Andres AC, Ziemiecki A (1998). "A novel family of serine/threonine kinases participating in spermiogenesis". J. Cell Biol. 139 (7): 1851–1859. doi:10.1083/jcb.139.7.1851. PMC 2132653 . PMID 9412477.
Gong W, Emanuel BS, Collins J, Kim DH, Wang Z, Chen F, Zhang G, Roe B, Budarf ML (1996). "A transcription map of the DiGeorge and velo-cardio-facial syndrome minimal critical region on 22q11". Hum. Mol. Genet. 5 (6): 789–800. CiteSeerX 10.1.1.539.9441 . doi:10.1093/hmg/5.6.789. PMID 8776594.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000206203 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045521 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10591208-5] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.

[entrez-6] "Entrez Gene: TSSK2 testis-specific serine kinase 2".

[1]

[2]

[3]

[4]

[5]

[6]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

TSSK2

Related Research Articles

References

Further reading