MAPK12

Last updated
MAPK12
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAPK12 , ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3, ERK-6, MAPK 12, mitogen-activated protein kinase 12
External IDs OMIM: 602399 MGI: 1353438 HomoloGene: 55705 GeneCards: MAPK12
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002969
NM_001303252

NM_013871

RefSeq (protein)

NP_001290181
NP_002960

NP_038899
NP_001389948
NP_001389949
NP_001389950
NP_001389951

Contents

Location (UCSC) Chr 22: 50.25 – 50.26 Mb Chr 15: 89.01 – 89.02 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene. [5]

Function

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [5]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000188130 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022610 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: mitogen-activated protein kinase 12".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.