MKNK1

MKNK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HW6, 2Y9Q
Identifiers
Aliases	MKNK1 , MNK1, MAP kinase interacting serine/threonine kinase 1, MAPK interacting serine/threonine kinase 1
External IDs	OMIM: 606724; MGI: 894316; HomoloGene: 37838; GeneCards: MKNK1; OMA:MKNK1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p33 Start 46,557,407 bp [1] End 46,616,843 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D1 Start 115,696,395 bp [2] End 115,736,447 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas spleen Descending thoracic aorta blood gastric mucosa secondary oocyte muscle layer of sigmoid colon right coronary artery upper lobe of left lung monocyte Top expressed in granulocyte secondary oocyte stroma of bone marrow primary oocyte neural layer of retina thymus lip muscle of thigh pancreas dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity calcium-dependent protein serine/threonine kinase activity calmodulin binding kinase activity protein binding calmodulin-dependent protein kinase activity ATP binding protein serine/threonine kinase activity metal ion binding Cellular component cytoplasm cytosol nucleoplasm nucleus Biological process intracellular signal transduction phosphorylation protein phosphorylation protein autophosphorylation regulation of translation peptidyl-serine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8569 17346 Ensembl ENSG00000079277 ENSMUSG00000028708 UniProt Q9BUB5 O08605 RefSeq (mRNA) NM_001135553 NM_003684 NM_198973 NM_001377337 NM_001377338 NM_001377341 NM_001377342 NM_001377343 NM_001377373 NM_001377374 NM_001377375 NM_001285487 NM_001285488 NM_021461 NM_001355174 NM_001369238 RefSeq (protein) NP_001129025 NP_003675 NP_945324 NP_001364266 NP_001364267 NP_001364270 NP_001364271 NP_001364272 NP_001364302 NP_001364303 NP_001364304 NP_001272416 NP_001272417 NP_067436 NP_001342103 NP_001356167 Location (UCSC) Chr 1: 46.56 – 46.62 Mb Chr 4: 115.7 – 115.74 Mb PubMed search [3] [4]
Wikidata
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MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene. ^{[5] [6]}

Interactions

MKNK1 has been shown to interact with MAPK1 ^[7] and Eukaryotic translation initiation factor 4 gamma. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000079277 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028708 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fukunaga R, Hunter T (Jun 1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J. 16 (8): 1921–33. doi:10.1093/emboj/16.8.1921. PMC   1169795 . PMID   9155018.
6. "Entrez Gene: MKNK1 MAP kinase interacting serine/threonine kinase 1".
7. Waskiewicz AJ, Flynn A, Proud C G, Cooper J A (Apr 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. 16 (8). ENGLAND: 1909–20. doi:10.1093/emboj/16.8.1909. ISSN   0261-4189. PMC   1169794 . PMID   9155017.
8. Pyronnet S, Imataka H, Gingras A C, Fukunaga R, Hunter T, Sonenberg N (Jan 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. 18 (1). ENGLAND: 270–9. doi:10.1093/emboj/18.1.270. ISSN   0261-4189. PMC   1171121 . PMID   9878069.

Further reading

• de Carvalho MG, McCormack AL, Olson E, et al. (1996). "Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes". J. Biol. Chem. 271 (12): 6987–97. doi: 10.1074/jbc.271.12.6987 . PMID   8636128.
• Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. PMC   1169794 . PMID   9155017.
• Börsch-Haubold AG, Bartoli F, Asselin J, et al. (1998). "Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells". J. Biol. Chem. 273 (8): 4449–58. doi: 10.1074/jbc.273.8.4449 . PMID   9468497.
• Pyronnet S, Imataka H, Gingras AC, et al. (1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. 18 (1): 270–9. doi:10.1093/emboj/18.1.270. PMC   1171121 . PMID   9878069.
• Waskiewicz AJ, Johnson JC, Penn B, et al. (1999). "Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo". Mol. Cell. Biol. 19 (3): 1871–80. doi:10.1128/MCB.19.3.1871. PMC   83980 . PMID   10022874.
• Cuesta R, Laroia G, Schneider RJ (2000). "Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes". Genes Dev. 14 (12): 1460–70. doi:10.1101/gad.14.12.1460. PMC   316692 . PMID   10859165.
• Hefner Y, Borsch-Haubold AG, Murakami M, et al. (2001). "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases". J. Biol. Chem. 275 (48): 37542–51. doi: 10.1074/jbc.M003395200 . PMID   10978317.
• Scheper GC, Morrice NA, Kleijn M, Proud CG (2001). "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells". Mol. Cell. Biol. 21 (3): 743–54. doi:10.1128/MCB.21.3.743-754.2001. PMC   86666 . PMID   11154262.
• Knauf U, Tschopp C, Gram H (2001). "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2". Mol. Cell. Biol. 21 (16): 5500–11. doi:10.1128/MCB.21.16.5500-5511.2001. PMC   87272 . PMID   11463832.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID   14499622.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Cuesta R, Xi Q, Schneider RJ (2004). "Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein". J. Virol. 78 (14): 7707–16. doi:10.1128/JVI.78.14.7707-7716.2004. PMC   434077 . PMID   15220445.
• Orton KC, Ling J, Waskiewicz AJ, et al. (2004). "Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk". J. Biol. Chem. 279 (37): 38649–57. doi: 10.1074/jbc.M407337200 . PMID   15234964.
• O'Loghlen A, González VM, Piñeiro D, et al. (2004). "Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1". Exp. Cell Res. 299 (2): 343–55. doi:10.1016/j.yexcr.2004.06.006. PMID   15350534.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Worch J, Tickenbrock L, Schwäble J, et al. (2005). "The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells". Oncogene. 23 (57): 9162–72. doi:10.1038/sj.onc.1208164. PMID   15516979. S2CID   25123414.
• Grund EM, Spyropoulos DD, Watson DK, Muise-Helmericks RC (2005). "Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells". J. Biol. Chem. 280 (6): 4772–8. doi: 10.1074/jbc.M408356200 . PMID   15563472.
• O'Loghlen A, González VM, Salinas M, Martín ME (2005). "Suppression of human Mnk1 by small interfering RNA increases the eukaryotic initiation factor 4F activity in HEK293T cells". FEBS Lett. 578 (1–2): 31–5. doi:10.1016/j.febslet.2004.10.063. PMID   15581611. S2CID   28489044.