MKNK1

MKNK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HW6, 2Y9Q
Identifiers
Aliases	MKNK1 , MNK1, MAP kinase interacting serine/threonine kinase 1, MAPK interacting serine/threonine kinase 1
External IDs	OMIM: 606724 MGI: 894316 HomoloGene: 37838 GeneCards: MKNK1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	46,616,843 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	115,736,447 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; spleen; ; blood; ; gastric mucosa; ; secondary oocyte; ; right coronary artery; ; upper lobe of left lung; ; monocyte; ; tibial nerve; ; ascending aorta;
	Top expressed in
	secondary oocyte; ; thymus; ; lip; ; pancreas; ; spleen; ; vastus lateralis muscle; ; calvaria; ; islet of Langerhans; ; parotid gland; ; lymph node;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein kinase activity ; calcium-dependent protein serine/threonine kinase activity ; calmodulin binding ; kinase activity ; protein binding ; calmodulin-dependent protein kinase activity ; ATP binding ; protein serine/threonine kinase activity ; metal ion binding ;
Cellular component	cytoplasm ; cytosol ; nucleoplasm ; nucleus ;
Biological process	intracellular signal transduction ; phosphorylation ; protein phosphorylation ; protein autophosphorylation ; regulation of translation ; peptidyl-serine phosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	8569
	17346
	ENSG00000079277
	ENSMUSG00000028708
	Q9BUB5
	O08605
NM_001135553 ; NM_003684 ; NM_198973 ; NM_001377337 ; NM_001377338 ;
	NM_001377341 ; NM_001377342 ; NM_001377343 ; NM_001377373 ; NM_001377374 ; NM_001377375 Contents Interactions ; References ; Further reading ;
	NM_001285487 ; NM_001285488 ; NM_021461 ; NM_001355174 ; NM_001369238
NP_001129025 ; NP_003675 ; NP_945324 ; NP_001364266 ; NP_001364267 ;
	NP_001364270 ; NP_001364271 ; NP_001364272 ; NP_001364302 ; NP_001364303 ; NP_001364304
	NP_001272416 ; NP_001272417 ; NP_067436 ; NP_001342103 ; NP_001356167
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2022

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.^[5]^[6]

Interactions

MKNK1 has been shown to interact with MAPK1 ^[7] and Eukaryotic translation initiation factor 4 gamma.^[8]

Related Research Articles

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Eukaryotic translation initiation factor 4E-binding protein 1 is a protein that in humans is encoded by the EIF4EBP1 gene.

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Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene.

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene. The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template. Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.

Mitogen-activated protein kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene.

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.

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MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene. The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases, including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000079277 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028708 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fukunaga R, Hunter T (Jun 1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J. 16 (8): 1921–33. doi:10.1093/emboj/16.8.1921. PMC 1169795 . PMID 9155018.
↑ "Entrez Gene: MKNK1 MAP kinase interacting serine/threonine kinase 1".
↑ Waskiewicz, A J; Flynn A; Proud C G; Cooper J A (Apr 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. ENGLAND. 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. ISSN 0261-4189. PMC 1169794 . PMID 9155017.
↑ Pyronnet, S; Imataka H; Gingras A C; Fukunaga R; Hunter T; Sonenberg N (Jan 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. ENGLAND. 18 (1): 270–9. doi:10.1093/emboj/18.1.270. ISSN 0261-4189. PMC 1171121 . PMID 9878069.

de Carvalho MG, McCormack AL, Olson E, et al. (1996). "Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes". J. Biol. Chem. 271 (12): 6987–97. doi: 10.1074/jbc.271.12.6987 . PMID 8636128.
Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. PMC 1169794 . PMID 9155017.
Börsch-Haubold AG, Bartoli F, Asselin J, et al. (1998). "Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells". J. Biol. Chem. 273 (8): 4449–58. doi: 10.1074/jbc.273.8.4449 . PMID 9468497.
Pyronnet S, Imataka H, Gingras AC, et al. (1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. 18 (1): 270–9. doi:10.1093/emboj/18.1.270. PMC 1171121 . PMID 9878069.
Waskiewicz AJ, Johnson JC, Penn B, et al. (1999). "Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo". Mol. Cell. Biol. 19 (3): 1871–80. doi:10.1128/MCB.19.3.1871. PMC 83980 . PMID 10022874.
Cuesta R, Laroia G, Schneider RJ (2000). "Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes". Genes Dev. 14 (12): 1460–70. doi:10.1101/gad.14.12.1460. PMC 316692 . PMID 10859165.
Hefner Y, Borsch-Haubold AG, Murakami M, et al. (2001). "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases". J. Biol. Chem. 275 (48): 37542–51. doi: 10.1074/jbc.M003395200 . PMID 10978317.
Scheper GC, Morrice NA, Kleijn M, Proud CG (2001). "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells". Mol. Cell. Biol. 21 (3): 743–54. doi:10.1128/MCB.21.3.743-754.2001. PMC 86666 . PMID 11154262.
Knauf U, Tschopp C, Gram H (2001). "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2". Mol. Cell. Biol. 21 (16): 5500–11. doi:10.1128/MCB.21.16.5500-5511.2001. PMC 87272 . PMID 11463832.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Cuesta R, Xi Q, Schneider RJ (2004). "Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein". J. Virol. 78 (14): 7707–16. doi:10.1128/JVI.78.14.7707-7716.2004. PMC 434077 . PMID 15220445.
Orton KC, Ling J, Waskiewicz AJ, et al. (2004). "Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk". J. Biol. Chem. 279 (37): 38649–57. doi: 10.1074/jbc.M407337200 . PMID 15234964.
O'Loghlen A, González VM, Piñeiro D, et al. (2004). "Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1". Exp. Cell Res. 299 (2): 343–55. doi:10.1016/j.yexcr.2004.06.006. PMID 15350534.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Worch J, Tickenbrock L, Schwäble J, et al. (2005). "The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells". Oncogene. 23 (57): 9162–72. doi: 10.1038/sj.onc.1208164 . PMID 15516979.
Grund EM, Spyropoulos DD, Watson DK, Muise-Helmericks RC (2005). "Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells". J. Biol. Chem. 280 (6): 4772–8. doi: 10.1074/jbc.M408356200 . PMID 15563472.
O'Loghlen A, González VM, Salinas M, Martín ME (2005). "Suppression of human Mnk1 by small interfering RNA increases the eukaryotic initiation factor 4F activity in HEK293T cells". FEBS Lett. 578 (1–2): 31–5. doi: 10.1016/j.febslet.2004.10.063 . PMID 15581611.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000079277 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028708 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9155018-5] Fukunaga R, Hunter T (Jun 1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J. 16 (8): 1921–33. doi:10.1093/emboj/16.8.1921. PMC 1169795 . PMID 9155018.

[entrez-6] "Entrez Gene: MKNK1 MAP kinase interacting serine/threonine kinase 1".

[pmid9155017-7] Waskiewicz, A J; Flynn A; Proud C G; Cooper J A (Apr 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. ENGLAND. 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. ISSN 0261-4189. PMC 1169794 . PMID 9155017.

[pmid9878069-8] Pyronnet, S; Imataka H; Gingras A C; Fukunaga R; Hunter T; Sonenberg N (Jan 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. ENGLAND. 18 (1): 270–9. doi:10.1093/emboj/18.1.270. ISSN 0261-4189. PMC 1171121 . PMID 9878069.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

MKNK1

Contents

Interactions

Related Research Articles

References

Further reading