PLK3

Last updated

PLK3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PLK3 , CNK, FNK, PRK, PLK-3, polo like kinase 3
External IDs OMIM: 602913; MGI: 109604; HomoloGene: 20865; GeneCards: PLK3; OMA:PLK3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004073

NM_013807
NM_001313916

RefSeq (protein)

NP_004064

n/a

Location (UCSC) Chr 1: 44.8 – 44.81 Mb Chr 4: 116.99 – 116.99 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene. [5] [6]

Contents

Function

Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis. [5]

Interactions

PLK3 has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000173846 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028680 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)".
  6. Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (August 1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J. Biol. Chem. 271 (32): 19402–8. doi: 10.1074/jbc.271.32.19402 . PMID   8702627.
  7. Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. 18 (44): 6029–36. doi: 10.1038/sj.onc.1202983 . PMID   10557092.
  8. 1 2 Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (Sep 2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene. 21 (43): 6633–40. doi:10.1038/sj.onc.1205850. PMID   12242661. S2CID   24106070.
  9. Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (Nov 2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. 276 (46): 43305–12. doi: 10.1074/jbc.M106050200 . PMID   11551930.

Further reading