KSR1

Last updated • a couple of secsFrom Wikipedia, The Free Encyclopedia
KSR1
Protein KSR1 PDB 1kbe.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KSR1 , KSR, RSU2, kinase suppressor of ras 1
External IDs OMIM: 601132 MGI: 105051 HomoloGene: 8410 GeneCards: KSR1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014238
NM_001367810
NM_001394583
NM_001394584
NM_001394585

NM_013571
NM_001348207

RefSeq (protein)

NP_055053
NP_001354739

NP_001335136
NP_038599

Location (UCSC) Chr 17: 27.46 – 27.63 Mb Chr 11: 78.9 – 79.04 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kinase suppressor of Ras 1 is an enzyme that in humans is encoded by the KSR1 gene. [5] [6]

Related Research Articles

<span class="mw-page-title-main">TNK2</span> Protein-coding gene in the species Homo sapiens

Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

<span class="mw-page-title-main">DOK2</span> Protein-coding gene in the species Homo sapiens

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.

<span class="mw-page-title-main">RRAS2</span> Protein-coding gene in the species Homo sapiens

Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene.

<span class="mw-page-title-main">PBK (gene)</span> Protein-coding gene in the species Homo sapiens

Lymphokine-activated killer T-cell-originated protein kinase is an enzyme that in humans is encoded by the PBK gene.

<span class="mw-page-title-main">DGKZ</span> Protein-coding gene in the species Homo sapiens

Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.

<span class="mw-page-title-main">RARRES3</span> Protein-coding gene in the species Homo sapiens

Retinoic acid receptor responder protein 3 is a protein that in humans is encoded by the RARRES3 gene.

<span class="mw-page-title-main">LATS1</span> Protein-coding gene in the species Homo sapiens

Large tumor suppressor kinase 1 (LATS1) is an enzyme that in humans is encoded by the LATS1 gene.

<span class="mw-page-title-main">CNKSR1</span> Protein-coding gene in the species Homo sapiens

Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the CNKSR1 gene.

<span class="mw-page-title-main">ELK3</span> Protein-coding gene in humans

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.

<span class="mw-page-title-main">SPRED2</span> Protein-coding gene in the species Homo sapiens

Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.

<span class="mw-page-title-main">MAPKAP1</span> Protein-coding gene in the species Homo sapiens

Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene. As the name indicates, it is a subunit of mTOR complex 2.

<span class="mw-page-title-main">DLGAP4</span> Protein-coding gene in the species Homo sapiens

Disks large-associated protein 4 (DAP-4) also known as SAP90/PSD-95-associated protein 4 (SAPAP-4) is a protein that in humans is encoded by the DLGAP4 gene.

<span class="mw-page-title-main">LATS2</span> Protein-coding gene in the species Homo sapiens

Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene.

<span class="mw-page-title-main">RSU1</span> Protein-coding gene in the species Homo sapiens

Ras suppressor protein 1 is a protein that in humans is encoded by the RSU1 gene.

<span class="mw-page-title-main">RASA3</span> Protein-coding gene in the species Homo sapiens

Ras GTPase-activating protein 3 is an enzyme that in humans is encoded by the RASA3 gene.

<span class="mw-page-title-main">GEM (gene)</span> Protein-coding gene in humans

GTP-binding protein GEM is a protein that in humans is encoded by the GEM gene.

<span class="mw-page-title-main">RASGRP1</span> Protein-coding gene in the species Homo sapiens

RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene.

<span class="mw-page-title-main">CNKSR2</span> Protein-coding gene in humans

Connector enhancer of kinase suppressor of ras 2, also known as CNK homolog protein 2 (CNK2) or MAGUIN, is an enzyme that in humans is encoded by the CNKSR2 gene.

<span class="mw-page-title-main">MAST1</span> Protein-coding gene in the species Homo sapiens

Microtubule-associated serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MAST1 gene.

<span class="mw-page-title-main">MAPK12</span> Protein-coding gene in the species Homo sapiens

Mitogen-activated protein kinase 12, also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000141068 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018334 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM (Jan 1996). "KSR, a novel protein kinase required for RAS signal transduction". Cell. 83 (6): 879–88. doi: 10.1016/0092-8674(95)90204-X . PMID   8521512. S2CID   16975824.
  6. "Entrez Gene: KSR1 kinase suppressor of ras 1".

Further reading