STK19

STK19
Identifiers
Aliases	STK19 , D6S60, D6S60E, G11, HLA-RP1, RP1, serine/threonine kinase 19
External IDs	OMIM: 604977 MGI: 1860085 HomoloGene: 10449 GeneCards: STK19
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.33 Start 31,971,091 bp [1] End 31,982,821 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 B1 Start 35,042,969 bp [2] End 35,055,921 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left adrenal gland right adrenal gland right lobe of liver anterior pituitary skin of abdomen spleen left uterine tube kidney left lobe of thyroid gland right lobe of thyroid gland Top expressed in bone marrow lip superior frontal gyrus islet of Langerhans duodenum jejunum proximal tubule adrenal gland cerebellar cortex esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein serine/threonine kinase activity ATP binding kinase activity protein binding Cellular component nucleus nuclear speck Biological process protein phosphorylation phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8859 54402 Ensembl ENSG00000226257 ENSG00000206342 ENSG00000236250 ENSG00000226033 ENSG00000204344 ENSG00000234947 ENSMUSG00000061207 UniProt P49842 Q9JHN8 RefSeq (mRNA) NM_004197 NM_032454 NM_019442 RefSeq (protein) NP_004188 NP_115830 NP_062315 Location (UCSC) Chr 6: 31.97 – 31.98 Mb Chr 17: 35.04 – 35.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase 19 is an enzyme that in humans is encoded by the STK19 gene. ^{[5] [6] [7]}

This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. ^[7]

See also

• RCCX

References

1. ENSG00000206342, ENSG00000236250, ENSG00000226033, ENSG00000204344, ENSG00000234947 GRCh38: Ensembl release 89: ENSG00000226257, ENSG00000206342, ENSG00000236250, ENSG00000226033, ENSG00000204344, ENSG00000234947 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061207 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sargent CA, Anderson MJ, Hsieh SL, Kendall E, Gomez-Escobar N, Campbell RD (Jul 1994). "Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex". Hum Mol Genet. 3 (3): 481–8. doi:10.1093/hmg/3.3.481. PMID   8012361.
6. Gomez-Escobar N, Chou CF, Lin WW, Hsieh SL, Campbell RD (Dec 1998). "The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase". J Biol Chem. 273 (47): 30954–60. doi: 10.1074/jbc.273.47.30954 . PMID   9812991.
7. "Entrez Gene: STK19 serine/threonine kinase 19".

Further reading

• Yu CY (1991). "The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene". J. Immunol. 146 (3): 1057–66. PMID   1988494.
• Shen L, Wu LC, Sanlioglu S, et al. (1994). "Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication". J. Biol. Chem. 269 (11): 8466–76. doi: 10.1016/S0021-9258(17)37217-4 . PMID   8132574.
• Ulgiati D, Townend DC, Christiansen FT, et al. (1996). "Complete sequence of the complement C4 gene from the HLA-A1, B8, C4AQ0, C4B1, DR3 haplotype". Immunogenetics. 43 (4): 250–2. doi:10.1007/s002510050059. PMID   8575831.
• Yang Z, Shen L, Dangel AW, et al. (1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID   9799600.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC   403804 . PMID   14656967.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID   14667819.
• Wadle A, Mischo A, Henrich PP, et al. (2005). "Characterization of Hap/BAG-1 variants as RP1 binding proteins with antiapoptotic activity". Int. J. Cancer. 117 (6): 896–904. doi:10.1002/ijc.21259. PMID   15986447. S2CID   36464436.