P21-activated kinases

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p21 activated kinases (PAKs) are members of a family of enzymes. [1] They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities.

Members include:

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PAK1 Mammalian protein found in Homo sapiens

Serine/threonine-protein kinase PAK 1 is an enzyme that in humans is encoded by the PAK1 gene.

PDGFRB Protein-coding gene in the species Homo sapiens

Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies.

PAK2 Mammalian protein found in Homo sapiens

Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene.

RACGAP1

Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the RACGAP1 gene.

LIMK1

LIM domain kinase 1 is an enzyme that in humans is encoded by the LIMK1 gene.

ARHGEF7 Protein-coding gene in the species Homo sapiens

Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene.

ARHGEF6 Protein-coding gene in the species Homo sapiens

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.

PAK3 Mammalian protein found in Homo sapiens

PAK3 is one of three members of Group I PAK family of evolutionary conserved serine/threonine kinases. PAK3 is preferentially expressed in neuronal cells and involved in synapse formation and plasticity and mental retardation.

PAK4 Mammalian protein found in Homo sapiens

Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene.

CDC42BPA Protein-coding gene in the species Homo sapiens

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.

PAK5

Serine/threonine-protein kinase PAK 5 is an enzyme that in humans is encoded by the PAK5 gene.

PAK6

Serine/threonine-protein kinase PAK 6 is an enzyme that in humans is encoded by the PAK6 gene.

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EVI5L Protein-coding gene in the species Homo sapiens

EVI5L is a protein that in humans is encoded by the EVI5L gene. EVI5L is a member of the Ras superfamily of monomeric guanine nucleotide-binding (G) proteins, and functions as a GTPase-activating protein (GAP) with a broad specificity. Measurement of in vitro Rab-GAP activity has shown that EVI5L has significant Rab2A- and Rab10-GAP activity.

References

  1. p21-Activated+Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
  2. "Entrez Gene: PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)".
  3. "Entrez Gene: PAK2 p21 (CDKN1A)-activated kinase 2".
  4. "Entrez Gene: PAK3 p21 (CDKN1A)-activated kinase 3".
  5. "Entrez Gene: PAK4 p21(CDKN1A)-activated kinase 4".
  6. "PAK5 p21 (RAC1) activated kinase 5 [Homo sapiens (human)] - Gene - NCBI".
  7. "PAK6 p21 (RAC1) activated kinase 6 [Homo sapiens (human)] - Gene - NCBI".