GNB1

Last updated

GNB1
Protein GNB1 PDB 1a0r.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GNB1 , G protein subunit beta 1, MRD42, MDS, HG2A
External IDs OMIM: 139380; MGI: 95781; HomoloGene: 55532; GeneCards: GNB1; OMA:GNB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002074
NM_001282538
NM_001282539

NM_001160016
NM_001160017
NM_008142

RefSeq (protein)

NP_001269467
NP_001269468
NP_002065

NP_001153488
NP_001153489
NP_032168

Location (UCSC) Chr 1: 1.79 – 1.89 Mb Chr 4: 155.58 – 155.64 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene. [5]

Function

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals. [5] [6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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NicotineDopaminergic WP1602.png go to articlego to articlego to articleGo to articlego to articleGo to articleGo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articleGo to articlego to articlego to articlego to articlego to articleGo to articleGo to articlego to articleGo to articleGo to articleGo to articlego to articleGo to articleGo to articleGo to articlego to articlego to articlego to articlego to articlego to articlego to articleGo to articlego to articleGo to articleGo to articlego to articlego to articleGo to articlego to articleGo to articleGo to articlego to article
|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
  1. The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

Interactions

GNB1 has been shown to interact with GNG4. [7] [8]

Mutations

Mutations in the GNB1 gene can cause developmental delays, seizures, and other health problems. The GNB1 Advocacy Group is the primary organization in the United States connecting patients to each other and to researchers working to cure the effects of these mutations.

www.facebook.com/groups/gnb1advocacy/

https://www.gnb1.org/

https://www.ncbi.nlm.nih.gov/books/NBK554743/

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000078369 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029064 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1".
  6. Ogorodnikov A, Levin M, Tattikota S, Tokalov S, Hoque M, Scherzinger D, Marini F, Poetsch A, Binder H, Macher-Göppinger S, Probst HC, Tian B, Schaefer M, Lackner KJ, Westermann F, Danckwardt S (December 2018). "Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma". Nat. Commun. 9 (1): 5331. Bibcode:2018NatCo...9.5331O. doi:10.1038/s41467-018-07580-5. PMC   6294251 . PMID   30552333.
  7. Ray K, Kunsch C, Bonner LM, Robishaw JD (September 1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765–71. doi: 10.1074/jbc.270.37.21765 . PMID   7665596.
  8. Yan K, Kalyanaraman V, Gautam N (March 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi: 10.1074/jbc.271.12.7141 . PMID   8636150.

Further reading