GNB2

Last updated
GNB2
Protein GNB2 PDB 1b9x.png
Identifiers
Aliases GNB2 , G protein subunit beta 2, SSS4, SSS4; NEDHYDF, HG2C1
External IDs OMIM: 139390; MGI: 95784; HomoloGene: 68451; GeneCards: GNB2; OMA:GNB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005273

NM_010312

RefSeq (protein)

NP_005264

NP_034442

Location (UCSC) Chr 7: 100.67 – 100.68 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 is a protein that in humans is encoded by the GNB2 gene. [4] [5]

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes.

This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000172354 Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC   310788 . PMID   9799793.
  5. 1 2 "Entrez Gene: GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2".

Further reading