GNG11

GNG11
Identifiers
Aliases	GNG11 , GNGT11, G protein subunit gamma 11, HG3H1
External IDs	OMIM: 604390 MGI: 1913316 HomoloGene: 3045 GeneCards: GNG11
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q21.3 Start 93,921,735 bp [1] End 93,928,610 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 A1 Start 4,003,904 bp [2] End 4,008,445 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium periodontal fiber monocyte stromal cell of endometrium lactiferous duct germinal epithelium seminal vesicula parietal pleura placenta adipose tissue Top expressed in blood right lung optic nerve right lung lobe left lung left lung lobe body of femur internal carotid artery external carotid artery atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity GTPase activity protein binding G-protein beta-subunit binding Cellular component plasma membrane membrane heterotrimeric G-protein complex G-protein beta/gamma-subunit complex Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2791 66066 Ensembl ENSG00000127920 ENSMUSG00000032766 UniProt P61952 P61953 RefSeq (mRNA) NM_004126 NM_025331 RefSeq (protein) NP_004117 NP_079607 Location (UCSC) Chr 7: 93.92 – 93.93 Mb Chr 6: 4 – 4.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 is a protein that in humans is encoded by the GNG11 gene. ^{[5] [6]}

This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein.

As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000127920 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032766 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ray K, Kunsch C, Bonner LM, Robishaw JD (Oct 1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J Biol Chem. 270 (37): 21765–71. doi: 10.1074/jbc.270.37.21765 . PMID   7665596.
6. "Entrez Gene: GNG11 guanine nucleotide binding protein (G protein), gamma 11".

Further reading

• Downes GB, Gautam N (2000). "The G protein subunit gene families". Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID   10644457.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi: 10.1074/jbc.M210304200 . PMID   12486123.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Ruiz-Ballesteros E, Mollejo M, Rodriguez A, et al. (2005). "Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis". Blood. 106 (5): 1831–8. doi: 10.1182/blood-2004-10-3898 . PMID   15914563.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Hossain MN, Sakemura R, Fujii M, Ayusawa D (2007). "G-protein gamma subunit GNG11 strongly regulates cellular senescence". Biochem. Biophys. Res. Commun. 351 (3): 645–50. doi:10.1016/j.bbrc.2006.10.112. PMID   17092487.