GNAI1

GNAI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KJY, 1Y3A, 2G83, 2GTP, 2IK8, 2OM2, 2XNS, 3ONW, 3QE0, 3QI2, 3UMR, 3UMS, 4G5Q, 5JS7, 5JS8
Identifiers
Aliases	GNAI1 , Gi, G protein subunit alpha i1, HG1B, NEDHISB
External IDs	OMIM: 139310 MGI: 95771 HomoloGene: 74417 GeneCards: GNAI1
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q21.11 Start 79,768,028 bp [1] End 80,226,181 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 A3|5 8.16 cM Start 18,470,133 bp [2] End 18,565,353 bp [2]
RNA expression pattern Bgee Top expressed in corpus callosum inferior ganglion of vagus nerve subthalamic nucleus Germinal epithelium pons oocyte secondary oocyte Superior vestibular nucleus external globus pallidus Ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activating protein binding nucleotide binding G-protein beta/gamma-subunit complex binding GDP binding G protein-coupled serotonin receptor binding signal transducer activity metal ion binding GO:0001948 protein binding guanyl nucleotide binding G protein-coupled receptor binding GTP binding magnesium ion binding GO:0006184 GTPase activity Cellular component cytoplasm centrosome membrane plasma membrane intracellular anatomical structure microtubule organizing center lysosomal membrane midbody heterotrimeric G-protein complex membrane raft extracellular exosome cytoskeleton nucleus nucleolus cell cortex region cell cortex protein-containing complex Biological process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway response to peptide hormone negative regulation of synaptic transmission cell division cell cycle signal transduction regulation of cAMP-mediated signaling cellular response to forskolin protein folding regulation of mitotic spindle organization positive regulation of protein localization to cell cortex transport G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2770	14677
Ensembl	ENSG00000127955	ENSMUSG00000057614
UniProt	P63096	B2RSH2
RefSeq (mRNA)	NM_002069 NM_001256414	NM_010305
RefSeq (protein)	NP_001243343 NP_002060	NP_034435
Location (UCSC)	Chr 7: 79.77 – 80.23 Mb	Chr 5: 18.47 – 18.57 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene. ^{[5] [6]}

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

1. The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

Interactions

GNAI1 has been shown to interact with:

• GPR143, ^[7]
• RGS12, ^[8]
• RGS14, ^{[8] [9]}
• RGS19, ^{[10] [11]}
• RIC8A, ^[12] and
• S1PR1. ^[13]

References

1. GRCh38: Ensembl release 89: ENSG00000127955 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057614 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M (Aug 1987). "Human cDNA clones for an alpha subunit of Gi signal-transduction protein". Proceedings of the National Academy of Sciences of the United States of America. 84 (15): 5115–9. Bibcode:1987PNAS...84.5115B. doi: 10.1073/pnas.84.15.5115 . PMC   298804 . PMID   3110783.
6. "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1".
7. Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A (Sep 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nature Genetics. 23 (1): 108–12. doi:10.1038/12715. PMID   10471510. S2CID   6604295.
8. Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (Aug 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". The Journal of Biological Chemistry. 276 (31): 29275–81. doi: 10.1074/jbc.M103208200 . PMID   11387333.
9. Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP (Apr 2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits". Nature. 416 (6883): 878–81. Bibcode:2002Natur.416..878K. doi:10.1038/416878a. PMID   11976690. S2CID   4406208.
10. Woulfe DS, Stadel JM (Jun 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". The Journal of Biological Chemistry. 274 (25): 17718–24. doi: 10.1074/jbc.274.25.17718 . PMID   10364213.
11. De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (26): 15203–8. Bibcode:1996PNAS...9315203D. doi: 10.1073/pnas.93.26.15203 . PMC   26381 . PMID   8986788.
12. Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry. 278 (10): 8356–62. doi: 10.1074/jbc.M211862200 . PMID   12509430.
13. Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272–9. doi: 10.1074/jbc.271.19.11272 . PMID   8626678.

Further reading

• Sidhu A, Niznik HB (Nov 2000). "Coupling of dopamine receptor subtypes to multiple and diverse G proteins". International Journal of Developmental Neuroscience. 18 (7): 669–77. doi:10.1016/S0736-5748(00)00033-2. PMID   10978845. S2CID   21002590.
• Brown EJ, Frazier WA (Mar 2001). "Integrin-associated protein (CD47) and its ligands". Trends in Cell Biology. 11 (3): 130–5. doi:10.1016/S0962-8924(00)01906-1. PMID   11306274.
• Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacology & Therapeutics. 92 (2–3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID   11916537.
• Jiang M, Pandey S, Tran VT, Fong HK (May 1991). "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 88 (9): 3907–11. Bibcode:1991PNAS...88.3907J. doi: 10.1073/pnas.88.9.3907 . PMC   51562 . PMID   1902575.
• Gennity JM, Siess W (Nov 1991). "Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of a novel soluble Gi-protein in human platelets". The Biochemical Journal. 279 (Pt 3): 643–50. doi:10.1042/bj2790643. PMC   1151493 . PMID   1953657.
• Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M, Kaziro Y (May 1988). "Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs". The Journal of Biological Chemistry. 263 (14): 6656–64. doi: 10.1016/S0021-9258(18)68692-2 . PMID   2834384.
• Bloch DB, Bloch KD, Iannuzzi M, Collins FS, Neer EJ, Seidman JG, Morton CC (Jun 1988). "The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus". American Journal of Human Genetics. 42 (6): 884–8. PMC   1715192 . PMID   3130752.
• Nagata K, Katada T, Tohkin M, Itoh H, Kaziro Y, Ui M, Nozawa Y (Sep 1988). "GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin". FEBS Letters. 237 (1–2): 113–7. doi:10.1016/0014-5793(88)80182-0. PMID   3139448. S2CID   27091750.
• Kagimoto S, Yamada Y, Kubota A, Someya Y, Ihara Y, Yasuda K, Kozasa T, Imura H, Seino S, Seino Y (Jul 1994). "Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein". Biochemical and Biophysical Research Communications. 202 (2): 1188–95. doi:10.1006/bbrc.1994.2054. PMID   7914078.
• Nitta K, Uchida K, Kawashima A, Tsutsui T, Ozu H, Naito T, Yumura W, Nihei H (Jan 1994). "Identification of GTP-binding proteins in human glomeruli". Nihon Jinzo Gakkai Shi. 36 (1): 9–12. PMID   8107314.
• Law SF, Zaina S, Sweet R, Yasuda K, Bell GI, Stadel J, Reisine T (Apr 1994). "Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation". Molecular Pharmacology. 45 (4): 587–90. PMID   8183236.
• Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (Jun 1993). "Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy". Endocrinology. 132 (6): 2484–90. doi:10.1210/endo.132.6.8504751. PMID   8504751.
• Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G (Jan 1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proceedings of the National Academy of Sciences of the United States of America. 93 (1): 116–20. Bibcode:1996PNAS...93..116L. doi: 10.1073/pnas.93.1.116 . PMC   40189 . PMID   8552586.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272–9. doi: 10.1074/jbc.271.19.11272 . PMID   8626678.
• De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (26): 15203–8. Bibcode:1996PNAS...9315203D. doi: 10.1073/pnas.93.26.15203 . PMC   26381 . PMID   8986788.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Popov S, Yu K, Kozasa T, Wilkie TM (Jul 1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro". Proceedings of the National Academy of Sciences of the United States of America. 94 (14): 7216–20. Bibcode:1997PNAS...94.7216P. doi: 10.1073/pnas.94.14.7216 . PMC   23796 . PMID   9207071.
• Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI (May 1998). "RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells". Journal of Neurochemistry. 70 (5): 1964–72. doi: 10.1046/j.1471-4159.1998.70051964.x . PMID   9572280. S2CID   31928913.