RGS19

RGS19
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CMZ
Identifiers
Aliases	RGS19 , GAIP, RGSGAIP, regulator of G-protein signaling 19, regulator of G protein signaling 19
External IDs	OMIM: 605071; MGI: 1915153; HomoloGene: 23320; GeneCards: RGS19; OMA:RGS19 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.33 Start 64,073,181 bp [1] End 64,079,988 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 H4|2 103.72 cM Start 181,330,212 bp [2] End 181,335,770 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood monocyte spleen bone marrow cells parotid gland trabecular bone lymph node amniotic fluid appendix Top expressed in granulocyte mesenteric lymph nodes external carotid artery spleen blood thymus internal carotid artery yolk sac condyle tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity protein binding G-protein alpha-subunit binding GTPase activity Cellular component cytoplasm Golgi apparatus membrane brush border heterotrimeric G-protein complex membrane raft clathrin-coated vesicle cytoplasmic vesicle plasma membrane Biological process G protein-coupled receptor signaling pathway small GTPase mediated signal transduction autophagy negative regulation of signal transduction positive regulation of GTPase activity response to ethanol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10287 56470 Ensembl ENSG00000171700 ENSMUSG00000002458 UniProt P49795 Q9CX84 RefSeq (mRNA) NM_001039467 NM_005873 NM_001291205 NM_001291206 NM_001291207 NM_001291208 NM_001291209 NM_001291210 NM_026446 RefSeq (protein) NP_001034556 NP_005864 NP_001278134 NP_001278135 NP_001278136 NP_001278137 NP_001278138 NP_001278139 NP_080722 Location (UCSC) Chr 20: 64.07 – 64.08 Mb Chr 2: 181.33 – 181.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene. ^{[5] [6]}

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. ^{[6] [7]}

Interactions

RGS19 has been shown to interact with GNAO1, ^{[8] [9]} GIPC1, ^[10] OSTM1, ^[11] GNAI1, ^{[8] [9]} GNAI3 ^{[5] [8] [9]} and GNAZ. ^{[8] [12]}

References

1. GRCh38: Ensembl release 89: ENSG00000171700 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002458 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. De Vries L, Mousli M, Wurmser A, Farquhar MG (January 1996). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc Natl Acad Sci U S A. 92 (25): 11916–20. doi: 10.1073/pnas.92.25.11916 . PMC   40514 . PMID   8524874.
6. "Entrez Gene: RGS19 regulator of G-protein signalling 19".
7. Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell. 86 (3): 445–452. doi: 10.1016/S0092-8674(00)80117-8 . PMID   8756726. S2CID   12427406.
8. De Vries, L; Elenko E; Hubler L; Jones T L; Farquhar M G (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (26). UNITED STATES: 15203–8. Bibcode:1996PNAS...9315203D. doi: 10.1073/pnas.93.26.15203 . ISSN   0027-8424. PMC   26381 . PMID   8986788.
9. Woulfe, D S; Stadel J M (June 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. 274 (25). UNITED STATES: 17718–24. doi: 10.1074/jbc.274.25.17718 . ISSN   0021-9258. PMID   10364213.
10. Lou, X; Yano H; Lee F; Chao M V; Farquhar M G (March 2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell. 12 (3). United States: 615–27. doi:10.1091/mbc.12.3.615. ISSN   1059-1524. PMC   30968 . PMID   11251075.
11. Fischer, Thierry; De Vries Luc; Meerloo Timo; Farquhar Marilyn Gist (July 2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. 100 (14). United States: 8270–5. Bibcode:2003PNAS..100.8270F. doi: 10.1073/pnas.1432965100 . ISSN   0027-8424. PMC   166218 . PMID   12826607.
12. Fan, X; Brass L F; Poncz M; Spitz F; Maire P; Manning D R (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. 275 (41). UNITED STATES: 32129–34. doi: 10.1074/jbc.M004577200 . ISSN   0021-9258. PMID   10906137.

Further reading

• Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell. 86 (3): 445–452. doi: 10.1016/S0092-8674(00)80117-8 . PMID   8756726. S2CID   12427406.
• De Vries L, Elenko E, Hubler L, et al. (1997). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203–8. Bibcode:1996PNAS...9315203D. doi: 10.1073/pnas.93.26.15203 . PMC   26381 . PMID   8986788.
• Ogier-Denis E, Petiot A, Bauvy C, Codogno P (1997). "Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells". J. Biol. Chem. 272 (39): 24599–603. doi: 10.1074/jbc.272.39.24599 . PMID   9305927.
• De Vries L, Elenko E, McCaffery JM, et al. (1998). "RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G proteins, is located on clathrin-coated vesicles". Mol. Biol. Cell. 9 (5): 1123–34. doi:10.1091/mbc.9.5.1123. PMC   25334 . PMID   9571244.
• Popov S, Yu K, Kozasa T, Wilkie TM (1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10 and GAIP retain GTPase activating protein activity in vitro". Proc Natl Acad Sci USA. 94 (14): 7216–20. Bibcode:1997PNAS...94.7216P. doi: 10.1073/pnas.94.14.7216 . PMC   23796 . PMID   9207071.
• Wang J, Ducret A, Tu Y, et al. (1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily". J. Biol. Chem. 273 (40): 26014–25. doi: 10.1074/jbc.273.40.26014 . PMID   9748280.
• De Vries L, Lou X, Zhao G, et al. (1998). "GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12340–5. Bibcode:1998PNAS...9512340D. doi: 10.1073/pnas.95.21.12340 . PMC   22833 . PMID   9770488.
• Fischer T, Elenko E, McCaffery JM, et al. (1999). "Clathrin-coated vesicles bearing GAIP possess GTPase-activating protein activity in vitro". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6722–7. Bibcode:1999PNAS...96.6722F. doi: 10.1073/pnas.96.12.6722 . PMC   21982 . PMID   10359779.
• Woulfe DS, Stadel JM (1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. 274 (25): 17718–24. doi: 10.1074/jbc.274.25.17718 . PMID   10364213.
• de Alba E, De Vries L, Farquhar MG, Tjandra N (1999). "Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling". J. Mol. Biol. 291 (4): 927–39. doi:10.1006/jmbi.1999.2989. PMID   10452897.
• Zheng B, Chen D, Farquhar MG (2000). "MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 3999–4004. Bibcode:2000PNAS...97.3999Z. doi: 10.1073/pnas.97.8.3999 . PMC   18131 . PMID   10760272.
• Fischer T, Elenko E, Wan L, et al. (2000). "Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4040–5. Bibcode:2000PNAS...97.4040F. doi: 10.1073/pnas.97.8.4040 . PMC   18141 . PMID   10760275.
• Ogier-Denis E, Pattingre S, El Benna J, Codogno P (2001). "Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells". J. Biol. Chem. 275 (50): 39090–5. doi: 10.1074/jbc.M006198200 . PMID   10993892.
• Ito E, Xie G, Maruyama K, Palmer PP (2000). "A core-promoter region functions bi-directionally for human opioid-receptor-like gene ORL1 and its 5'-adjacent gene GAIP". J. Mol. Biol. 304 (3): 259–70. doi:10.1006/jmbi.2000.4212. PMID   11090272.
• Lou X, Yano H, Lee F, et al. (2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell. 12 (3): 615–27. doi:10.1091/mbc.12.3.615. PMC   30968 . PMID   11251075.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Ross EM, Wilkie TM (2000). "GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins". Annual Review of Biochemistry. 69: 795–827. doi:10.1146/annurev.biochem.69.1.795. PMID   10966476.
• Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID   11829488. S2CID   16065132.
• Kirikoshi H, Katoh M (2002). "Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors". Int. J. Mol. Med. 9 (5): 509–13. doi:10.3892/ijmm.9.5.509. PMID   11956658.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Xie GX, Han X, Ito E, et al. (2003). "Gene structure, dual-promoters and mRNA alternative splicing of the human and mouse regulator of G protein signaling GAIP/RGS19". J. Mol. Biol. 325 (4): 721–32. doi:10.1016/S0022-2836(02)01283-4. PMID   12507475.
• Fischer T, De Vries L, Meerloo T, Farquhar MG (2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8270–5. Bibcode:2003PNAS..100.8270F. doi: 10.1073/pnas.1432965100 . PMC   166218 . PMID   12826607.

External links

• RGS19 human gene location in the UCSC Genome Browser .
• RGS19 human gene details in the UCSC Genome Browser .