RIC8A

Last updated
RIC8A
Identifiers
Aliases RIC8A , RIC8, RIC8 guanine nucleotide exchange factor A
External IDs OMIM: 609146 MGI: 2141866 HomoloGene: 23331 GeneCards: RIC8A
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286134
NM_021932
NM_001386941
NM_001386942

NM_053194

RefSeq (protein)

NP_001273063
NP_068751

NP_444424

Location (UCSC) Chr 11: 0.21 – 0.22 Mb Chr 7: 140.44 – 140.44 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Resistance to inhibitors of cholinesterase-8A (Ric-8A), also known as Synembryn-A, is a protein that in humans is encoded by the RIC8A gene. [5] [6] [7]

Contents

Interactions

RIC8A has been shown to interact with GNAO1, [8] GNA13, [9] [8] GNAQ, [8] [10] GNAS complex locus, [10] GNAI2, [8] GNAI1 [8] and GNAI3. [8]

Related Research Articles

<span class="mw-page-title-main">GNAQ</span> Protein-coding gene in the species Homo sapiens

Guanine nucleotide-binding protein G(q) subunit alpha is a protein that in humans is encoded by the GNAQ gene. Together with GNA11, it functions as a Gq alpha subunit.

<span class="mw-page-title-main">GNAI2</span> Protein-coding gene in humans

Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene.

<span class="mw-page-title-main">GNAI1</span> Protein-coding gene in humans

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.

<span class="mw-page-title-main">GNAO1</span> Protein-coding gene in the species Homo sapiens

Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene.

<span class="mw-page-title-main">EIF2B3</span> Protein-coding gene in the species Homo sapiens

Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the EIF2B3 gene.

<span class="mw-page-title-main">RGS5</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene.

<span class="mw-page-title-main">TRIOBP</span> Protein-coding gene in the species Homo sapiens

TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.

<span class="mw-page-title-main">GNG12</span> Protein-coding gene in the species Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 is a protein that in humans is encoded by the GNG12 gene.

<span class="mw-page-title-main">MTG1</span> Protein-coding gene in the species Homo sapiens

Mitochondrial GTPase 1 is an enzyme that in humans is encoded by the MTG1 gene.

<span class="mw-page-title-main">RGS14</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene.

<span class="mw-page-title-main">GNG3</span> Protein-coding gene in the species Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene.

<span class="mw-page-title-main">GNB4</span> Protein-coding gene in the species Homo sapiens

Guanine nucleotide-binding protein subunit beta-4 is a protein that in humans is encoded by the GNB4 gene.

<span class="mw-page-title-main">DNAJC7</span> Protein-coding gene in the species Homo sapiens

DnaJ homolog subfamily C member 7 is a protein that in humans is encoded by the DNAJC7 gene.

<span class="mw-page-title-main">GNG5</span> Protein-coding gene in the species Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 is a protein that in humans is encoded by the GNG5 gene.

<span class="mw-page-title-main">NET1</span> Protein-coding gene in the species Homo sapiens

Neuroepithelial cell-transforming gene 1 protein is a protein that in humans is encoded by the NET1 gene.

<span class="mw-page-title-main">CD320</span> Human gene

CD320 is a human gene.

<span class="mw-page-title-main">GNA12</span> Protein-coding gene in the species Homo sapiens

Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.

<span class="mw-page-title-main">RIC3</span> Protein-coding gene in the species Homo sapiens

RIC-3 also known as resistance to inhibitors of cholinesterase 3 is a chaperone protein that in humans is encoded by the RIC3 gene. The RIC3 gene was first discovered in C. elegans. RIC-3 protein is conserved in most animals and influences the maturation of various ligand gated ion channels including the serotonin 5-HT3 receptor and nicotinic acetylcholine receptors, particularly the homomeric α7 nicotinic receptor. RIC-3 enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number.

<span class="mw-page-title-main">ARHGEF10</span> Protein-coding gene in the species Homo sapiens

The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10.

<span class="mw-page-title-main">TOX4</span> Protein-coding gene in the species Homo sapiens

TOX4 also known as KIAA0737, is a human gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000177963 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025485 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Miller KG, Emerson MD, McManus JR, Rand JB (Sep 2000). "RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system". Neuron. 27 (2): 289–99. doi:10.1016/S0896-6273(00)00037-4. PMC   4704990 . PMID   10985349.
  6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
  7. "Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)".
  8. 1 2 3 4 5 6 Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. United States. 278 (10): 8356–62. doi: 10.1074/jbc.M211862200 . ISSN   0021-9258. PMID   12509430.
  9. Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011). "Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization". The Journal of Biological Chemistry. 286 (35): 31055–61. doi: 10.1074/jbc.M111.253427 . PMC   3162464 . PMID   21771786.
  10. 1 2 Klattenhoff, Carla; Montecino Martín; Soto Ximena; Guzmán Leonardo; Romo Ximena; García María Angeles; Mellstrom Britt; Naranjo José Ramón; Hinrichs María Victoria; Olate Juan (May 2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol". J. Cell. Physiol. United States. 195 (2): 151–7. doi:10.1002/jcp.10300. hdl: 10533/174200 . ISSN   0021-9541. PMID   12652642. S2CID   84975473.

Further reading