RIC8A

Last updated
RIC8A
Identifiers
Aliases RIC8A , RIC8, RIC8 guanine nucleotide exchange factor A
External IDs OMIM: 609146; MGI: 2141866; HomoloGene: 23331; GeneCards: RIC8A; OMA:RIC8A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286134
NM_021932
NM_001386941
NM_001386942

NM_053194

RefSeq (protein)

NP_001273063
NP_068751

NP_444424

Location (UCSC) Chr 11: 0.21 – 0.22 Mb Chr 7: 140.44 – 140.44 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Resistance to inhibitors of cholinesterase-8A (Ric-8A), also known as Synembryn-A, is a protein that in humans is encoded by the RIC8A gene. [5] [6] [7]

Contents

Interactions

RIC8A has been shown to interact with GNAO1, [8] GNA13, [9] [8] GNAQ, [8] [10] GNAS complex locus, [10] GNAI2, [8] GNAI1 [8] and GNAI3. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000177963 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025485 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Miller KG, Emerson MD, McManus JR, Rand JB (Sep 2000). "RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system". Neuron. 27 (2): 289–99. doi:10.1016/S0896-6273(00)00037-4. PMC   4704990 . PMID   10985349.
  6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
  7. "Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)".
  8. 1 2 3 4 5 6 Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. 278 (10). United States: 8356–62. doi: 10.1074/jbc.M211862200 . ISSN   0021-9258. PMID   12509430.
  9. Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011). "Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization". The Journal of Biological Chemistry. 286 (35): 31055–61. doi: 10.1074/jbc.M111.253427 . PMC   3162464 . PMID   21771786.
  10. 1 2 Klattenhoff, Carla; Montecino Martín; Soto Ximena; Guzmán Leonardo; Romo Ximena; García María Angeles; Mellstrom Britt; Naranjo José Ramón; Hinrichs María Victoria; Olate Juan (May 2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol". J. Cell. Physiol. 195 (2). United States: 151–7. doi:10.1002/jcp.10300. hdl: 10533/174200 . ISSN   0021-9541. PMID   12652642. S2CID   84975473.

Further reading