Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.
Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor -like 1" which has an official symbol of NFE2L1.
Regulator of G-protein signaling 2 is a protein that in humans is encoded by the RGS2 gene. It is part of a larger family of RGS proteins that control signalling through G-protein coupled receptors (GPCR).
C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.
GGL domain is domain found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling RGS proteins.
Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene. This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.
Calsenilin is a protein that in humans is encoded by the KCNIP3 gene.
Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.
Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene. Alternatively spliced transcript variants encoding different isoforms exist.
Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.
Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.
Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.
Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene.
Guanine nucleotide-binding protein subunit beta-4 is a protein that in humans is encoded by the GNB4 gene.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 is a protein that in humans is encoded by the GNG13 gene.
Pirin is a protein that in humans is encoded by the PIR gene.
LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.
GoLoco motif is a protein structural motif. In heterotrimeric G-protein signalling, cell surface receptors (GPCRs) are coupled to membrane-associated heterotrimers comprising a GTP-hydrolyzing subunit G-alpha and a G-beta/G-gamma dimer. The inactive form contains the alpha subunit bound to GDP and complexes with the beta and gamma subunit. When the ligand is associated to the receptor, GDP is displaced from G-alpha and GTP is bound. The GTP/G-alpha complex dissociates from the trimer and associates to an effector until the intrinsic GTPase activity of G-alpha returns the protein to GDP bound form. Reassociation of GDP-bound G-alpha with G-beta/G-gamma dimer terminates the signal. Several mechanisms regulate the signal output at different stage of the G-protein cascade. Two classes of intracellular proteins act as inhibitors of G protein activation: GTPase activating proteins (GAPs), which enhance GTP hydrolysis, and guanine dissociation inhibitors (GDIs), which inhibit GDP dissociation. The GoLoco or G-protein regulatory (GPR) motif found in various G-protein regulators. acts as a GDI on G-alpha(i).
David Siderovski is a North American pharmacologist. Since March 2020, Siderovski has been Chair of the HSC Department of Pharmacology & Neuroscience at the University of North Texas Health Science Center. From 2012 to 2019, he was the E.J. Van Liere Medicine Professor and Chair of Physiology, Pharmacology & Neuroscience for the West Virginia University School of Medicine.
