RGS12

RGS12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EBZ, 2KV8
Identifiers
Aliases	RGS12 , regulator of G protein signaling 12
External IDs	OMIM: 602512; MGI: 1918979; HomoloGene: 2195; GeneCards: RGS12; OMA:RGS12 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p16.3 Start 3,293,021 bp [1] End 3,439,913 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 B2|5 17.96 cM Start 35,106,789 bp [2] End 35,196,988 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone mucosa of esophagus skin of leg right uterine tube skin of abdomen right frontal lobe right hemisphere of cerebellum prefrontal cortex ectocervix Top expressed in spermatocyte lip hand ventricular zone genital tubercle Rostral migratory stream spermatid ganglionic eminence dentate gyrus of hippocampal formation granule cell lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase regulator activity GTPase activator activity GTPase activity Cellular component cytoplasm cell projection nuclear matrix synapse condensed nuclear chromosome cell junction dendrite plasma membrane nucleus nucleolus cytosol Biological process regulation of G protein-coupled receptor signaling pathway transcription, DNA-templated positive regulation of GTPase activity negative regulation of signal transduction signal transduction regulation of catalytic activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6002 71729 Ensembl ENSG00000159788 ENSMUSG00000029101 UniProt O14924 Q8CGE9 RefSeq (mRNA) NM_002926 NM_198227 NM_198229 NM_198230 NM_198430 NM_198432 NM_198587 NM_001394154 NM_001394155 NM_001394156 NM_001394157 NM_001394158 NM_001394159 NM_001394161 NM_001394162 NM_001394163 NM_001163512 NM_173402 RefSeq (protein) NP_002917 NP_937870 NP_937872 NP_001156984 NP_775578 NP_001390400 NP_001390401 NP_001390402 NP_001390403 NP_001390404 NP_001390405 NP_001390406 NP_001390407 Location (UCSC) Chr 4: 3.29 – 3.44 Mb Chr 5: 35.11 – 35.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene. ^{[5] [6]}

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. ^[6]

Interactions

RGS12 has been shown to interact with GNAI1, ^[7] GNAI3, ^[7] and the kappa opioid receptor. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000159788 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029101 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (August 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem. 273 (28): 17749–55. doi: 10.1074/jbc.273.28.17749 . PMID   9651375.
6. "Entrez Gene: RGS12 regulator of G-protein signalling 12".
7. Kimple RJ, De Vries L, Tronchère H, Behe C I, Morris R A, Gist Farquhar M, Siderovski D P (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31): 29275–81. doi: 10.1074/jbc.M103208200 . ISSN   0021-9258. PMID   11387333.
8. Gross JD, Kaski SW, Schmidt KT, Cogan ES, Boyt KM, Wix K, Schroer AB, McElligott ZA, Siderovski DP, Setola V (September 2019). "Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior". Neuropsychopharmacology. 44 (10): 1728–1741. doi:10.1038/s41386-019-0423-7. PMC   6785087 . PMID   31141817.

Further reading

• Frohme M, Scharm B, Delius H, et al. (2000). "Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue". Ann. N. Y. Acad. Sci. 910 (1): 85–104, discussion 104–5. Bibcode:2000NYASA.910...85F. doi:10.1111/j.1749-6632.2000.tb06703.x. PMID   10911908. S2CID   25399395.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Snow BE, Antonio L, Suggs S, et al. (1997). "Molecular cloning and expression analysis of rat Rgs12 and Rgs14". Biochem. Biophys. Res. Commun. 233 (3): 770–7. doi:10.1006/bbrc.1997.6537. PMID   9168931.
• Chatterjee TK, Fisher RA (2000). "Novel alternative splicing and nuclear localization of human RGS12 gene products". J. Biol. Chem. 275 (38): 29660–71. doi: 10.1074/jbc.M000330200 . PMID   10869340.
• Schiff ML, Siderovski DP, Jordan JD, et al. (2001). "Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel". Nature. 408 (6813): 723–7. doi:10.1038/35047093. PMID   11130074. S2CID   205011654.
• Kimple RJ, De Vries L, Tronchère H, et al. (2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31): 29275–81. doi: 10.1074/jbc.M103208200 . PMID   11387333.
• Snow BE, Brothers GM, Siderovski DP (2002). "Molecular Cloning of Regulators of G-Protein Signaling Family Members and Characterization of Binding Specificity of RGS 12 PDZ Domain". G Protein Pathways, Part B: G Proteins and their Regulators. Methods in Enzymology. Vol. 344. pp. 740–61. doi:10.1016/S0076-6879(02)44752-0. ISBN   978-0-12-182245-3. PMID   11771424.
• Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID   11829488. S2CID   16065132.
• Chatterjee TK, Fisher RA (2002). "RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression". Mol. Cell. Biol. 22 (12): 4334–45. doi:10.1128/MCB.22.12.4334-4345.2002. PMC   133853 . PMID   12024043.
• Potocnik U, Glavac D, Ravnik-Glavac M (2003). "Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability". Genes Chromosomes Cancer. 36 (1): 48–56. doi:10.1002/gcc.10141. PMID   12461749. S2CID   30132562.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Yang S, Li YP (2007). "RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro". J. Bone Miner. Res. 22 (1): 45–54. doi:10.1359/jbmr.061007. PMC   3559086 . PMID   17042716.
• Gross JD, Kaski SW, Schroer AB, Wix KA, Siderovski DP, Setola V (2018). "Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants". J. Psychopharmacol. 32 (2): 191–203. doi:10.1177/0269881117742100. PMC   5942192 . PMID   29364035.
• Gross JD, Kaski SW, Schmidt KT, Cogan ES, Boyt KM, Wix K, Schroer AB, McElligott ZA, Siderovski DP (2019-05-29). "Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior". Neuropsychopharmacology. 44 (10): 1728–1741. doi:10.1038/s41386-019-0423-7. ISSN   1740-634X. PMC   6785087 . PMID   31141817.
• Schroer AB, Mohamed JS, Willard MD, Setola V, Oestreich E, Siderovski DP (2019). "A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation". PLOS ONE. 14 (8): e0216167. Bibcode:2019PLoSO..1416167S. doi: 10.1371/journal.pone.0216167 . PMC   6691989 . PMID   31408461.