GNAT3

GNAT3
Identifiers
Aliases	GNAT3 , GDCA, G protein subunit alpha transducin 3, HG1E
External IDs	OMIM: 139395 MGI: 3588268 HomoloGene: 24284 GeneCards: GNAT3
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q21.11 Start 80,458,635 bp [1] End 80,512,064 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 A3 Start 18,167,547 bp [2] End 18,224,832 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle duodenum abdominal wall mucosa of small intestine prefrontal cortex right lobe of thyroid gland left lobe of thyroid gland reproductive system large intestine reproductive organ Top expressed in mucosa of large intestine Intestinal epithelium tongue mucosa of small intestine vallate papilla secondary oocyte white adipose tissue thymus ileum jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity metal ion binding nucleotide binding guanyl nucleotide binding G protein-coupled receptor binding G-protein beta/gamma-subunit complex binding GTP binding GTPase activity Cellular component acrosomal vesicle cytoplasm axoneme heterotrimeric G-protein complex apical plasma membrane plasma membrane photoreceptor outer segment photoreceptor inner segment protein-containing complex Biological process signal transduction sensory perception of umami taste response to nicotine adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway sensory perception of bitter taste sensory perception of taste sensory perception of sweet taste protein folding detection of chemical stimulus involved in sensory perception of bitter taste G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 346562 242851 Ensembl ENSG00000214415 ENSMUSG00000028777 UniProt A8MTJ3 Q3V3I2 RefSeq (mRNA) NM_001102386 NM_001081143 RefSeq (protein) NP_001095856 NP_001074612 Location (UCSC) Chr 7: 80.46 – 80.51 Mb Chr 5: 18.17 – 18.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein G(t) subunit alpha-3, also known as gustducin alpha-3 chain, is a protein subunit that in humans is encoded by the GNAT3 gene. ^[5]

Gustducin alpha-3 chain is a subunit of the heterotrimeric G protein gustducin that is responsible for basic taste.

References

1. GRCh38: Ensembl release 89: ENSG00000214415 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028777 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: guanine nucleotide binding protein".

Further reading

• Oldham WM, Van Eps N, Preininger AM, et al. (2006). "Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins". Nat. Struct. Mol. Biol. 13 (9): 772–7. doi:10.1038/nsmb1129. PMID   16892066. S2CID   290532.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Rozengurt N, Wu SV, Chen MC, et al. (2006). "Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon". Am. J. Physiol. Gastrointest. Liver Physiol. 291 (5): G792-802. doi:10.1152/ajpgi.00074.2006. PMID   16728727.
• Huang L, Shanker YG, Dubauskaite J, et al. (1999). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium". Nat. Neurosci. 2 (12): 1055–62. doi:10.1038/15981. PMID   10570481. S2CID   24494794.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Luttrell LM (2008). "Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors". Mol. Biotechnol. 39 (3): 239–64. doi:10.1007/s12033-008-9031-1. PMID   18240029. S2CID   45173229.
• Margolskee RF, Dyer J, Kokrashvili Z, et al. (2007). "T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1". Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15075–80. Bibcode:2007PNAS..10415075M. doi: 10.1073/pnas.0706678104 . PMC   1986615 . PMID   17724332.
• Takami S, Getchell TV, McLaughlin SK, et al. (1994). "Human taste cells express the G protein alpha-gustducin and neuron-specific enolase". Brain Res. Mol. Brain Res. 22 (1–4): 193–203. doi:10.1016/0169-328X(94)90047-7. PMID   8015379.
• Jang HJ, Kokrashvili Z, Theodorakis MJ, et al. (2007). "Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1". Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15069–74. Bibcode:2007PNAS..10415069J. doi: 10.1073/pnas.0706890104 . PMC   1986614 . PMID   17724330.
• Li X, Staszewski L, Xu H, et al. (2002). "Human receptors for sweet and umami taste". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. Bibcode:2002PNAS...99.4692L. doi: 10.1073/pnas.072090199 . PMC   123709 . PMID   11917125.
• Fehr J, Meyer D, Widmayer P, et al. (2007). "Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa". J. Comp. Physiol. A. 193 (1): 21–34. doi:10.1007/s00359-006-0168-8. PMID   17021831. S2CID   25762931.
• Lambright DG, Noel JP, Hamm HE, Sigler PB (1994). "Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein". Nature. 369 (6482): 621–8. Bibcode:1994Natur.369..621L. doi:10.1038/369621a0. PMID   8208289. S2CID   4238569.