GNA11

GNA11
Identifiers
Aliases	GNA11 , FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2, G protein subunit alpha 11, HG1K
External IDs	OMIM: 139313; MGI: 95766; HomoloGene: 20474; GeneCards: GNA11; OMA:GNA11 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 3,094,362 bp [1] End 3,123,999 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 C1|10 39.72 cM Start 81,364,558 bp [2] End 81,381,024 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum jejunal mucosa pancreatic ductal cell duodenum mucosa of transverse colon secondary oocyte cerebellar vermis parotid gland right hemisphere of cerebellum stromal cell of endometrium Top expressed in crypt of lieberkuhn of small intestine duodenum jejunum ileum intestinal villus migratory enteric neural crest cell epithelium of small intestine left colon Ileal epithelium Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding type 2A serotonin receptor binding GTP binding metal ion binding guanyl nucleotide binding G protein-coupled receptor binding GTPase activity signal transducer activity G-protein beta/gamma-subunit complex binding protein binding Cellular component cytoplasm membrane plasma membrane photoreceptor outer segment lysosomal membrane extracellular exosome heterotrimeric G-protein complex Biological process G protein-coupled acetylcholine receptor signaling pathway skeletal system development regulation of melanocyte differentiation entrainment of circadian clock platelet activation heart development cellular response to pH phospholipase C-activating dopamine receptor signaling pathway phototransduction, visible light developmental pigmentation action potential signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2767 14672 Ensembl ENSG00000088256 ENSMUSG00000034781 UniProt P29992 P21278 RefSeq (mRNA) NM_002067 NM_010301 RefSeq (protein) NP_002058 NP_034431 Location (UCSC) Chr 19: 3.09 – 3.12 Mb Chr 10: 81.36 – 81.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene. ^{[5] [6]} Together with GNAQ (its paralogue), it functions as a Gq alpha subunit. ^[7]

See also

• Gq alpha subunit

References

1. GRCh38: Ensembl release 89: ENSG00000088256 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034781 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID   1302014. S2CID   31888533.
6. "Entrez Gene: GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)".
7. 139313 GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-11; GNA11 at OMIM. Retrieved January 1, 2015.

Further reading

• Raymond JR, Mukhin YV, Gelasco A, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacol. Ther. 92 (2–3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID   11916537.
• Jiang M, Pandey S, Tran VT, Fong HK (1991). "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3907–11. Bibcode:1991PNAS...88.3907J. doi: 10.1073/pnas.88.9.3907 . PMC   51562 . PMID   1902575.
• Thomas CP, Dunn MJ, Mattera R (1996). "Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways". Biochem. J. 312 (1): 151–8. doi:10.1042/bj3120151. PMC   1136238 . PMID   7492305.
• Offermanns S, Simon MI (1995). "G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C". J. Biol. Chem. 270 (25): 15175–80. doi: 10.1074/jbc.270.25.15175 . PMID   7797501.
• Stanners J, Kabouridis PS, McGuire KL, Tsoukas CD (1996). "Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling". J. Biol. Chem. 270 (51): 30635–42. doi: 10.1074/jbc.270.51.30635 . PMID   8530500.
• Laugwitz KL, Allgeier A, Offermanns S, et al. (1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. Bibcode:1996PNAS...93..116L. doi: 10.1073/pnas.93.1.116 . PMC   40189 . PMID   8552586.
• Launay JM, Birraux G, Bondoux D, et al. (1996). "Ras involvement in signal transduction by the serotonin 5-HT2B receptor". J. Biol. Chem. 271 (6): 3141–7. doi: 10.1074/jbc.271.6.3141 . PMID   8621713.
• Johnson GJ, Leis LA, Dunlop PC (1996). "Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences". Biochem. J. 318 (3): 1023–31. doi:10.1042/bj3181023. PMC   1217719 . PMID   8836152.
• Kinsella BT, O'Mahony DJ, Fitzgerald GA (1997). "The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha". J. Pharmacol. Exp. Ther. 281 (2): 957–64. PMID   9152406.
• Wise A, Parenti M, Milligan G (1997). "Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association". FEBS Lett. 407 (3): 257–60. doi:10.1016/S0014-5793(97)00300-1. PMID   9175863. S2CID   85622146.
• Carrasco MP, Asbóth G, Phaneuf S, López Bernal A (1998). "Activation of the prostaglandin FP receptor in human granulosa cells". J. Reprod. Fertil. 111 (2): 309–17. doi: 10.1530/jrf.0.1110309 . PMID   9462300.
• Qian A, Wang W, Sanborn BM (1998). "Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11)". Cell. Signal. 10 (2): 101–5. doi:10.1016/S0898-6568(97)00097-1. PMID   9481484.
• Dulin NO, Sorokin A, Reed E, et al. (1999). "RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11". Mol. Cell. Biol. 19 (1): 714–23. doi:10.1128/MCB.19.1.714. PMC   83928 . PMID   9858594.
• Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). "The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling". J. Biol. Chem. 274 (34): 23707–18. doi: 10.1074/jbc.274.34.23707 . PMID   10446129.
• Brydon L, Roka F, Petit L, et al. (2000). "Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins". Mol. Endocrinol. 13 (12): 2025–38. doi: 10.1210/mend.13.12.0390 . PMID   10598579.
• Corbetta S, Mantovani G, Lania A, et al. (2000). "Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia". Clin. Endocrinol. 52 (3): 339–48. doi:10.1046/j.1365-2265.2000.00933.x. PMID   10718832. S2CID   39998840.
• Shraga-Levine Z, Sokolovsky M (2000). "Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific". Cell. Mol. Neurobiol. 20 (3): 305–17. doi:10.1023/A:1007010125316. PMC   11537521 . PMID   10789830. S2CID   21841332.
• AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U (2001). "The angiotensin II AT2 receptor is an AT1 receptor antagonist". J. Biol. Chem. 276 (43): 39721–6. doi: 10.1074/jbc.M105253200 . PMID   11507095.