ATP2B3

ATP2B3
Identifiers
Aliases	ATP2B3 , CFAP39, CLA2, OPCA, PMCA3, PMCA3a, SCAX1, ATPase plasma membrane Ca2+ transporting 3
External IDs	OMIM: 300014 MGI: 1347353 HomoloGene: 123775 GeneCards: ATP2B3
Gene location (Human)
Chr.	X chromosome (human)
End	153,582,939 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	72,614,611 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; frontal pole; ; superior frontal gyrus; ; cerebellar vermis; ; postcentral gyrus; ; dorsolateral prefrontal cortex; ; Brodmann area 10; ; entorhinal cortex;
	Top expressed in
	cerebellar cortex; ; hippocampus proper; ; superior frontal gyrus; ; hypothalamus; ; adrenal gland; ; basal forebrain; ; secondary oocyte; ; olfactory bulb; ; muscle tissue; ; skeletal muscle tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding ; nucleotide binding ; hydrolase activity ; PDZ domain binding ; calmodulin binding ; ATP binding ; P-type calcium transporter activity ; protein binding ; calcium ion transmembrane transporter activity ; P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration ;
Cellular component	extracellular vesicle ; integral component of membrane ; Golgi apparatus ; intracellular membrane-bounded organelle ; integral component of plasma membrane ; membrane ; plasma membrane ; presynapse ; glutamatergic synapse ; GABA-ergic synapse ;
Biological process	calcium ion transport ; regulation of cardiac conduction ; cellular calcium ion homeostasis ; ion transport ; calcium ion transmembrane transport ; ion transmembrane transport ; transport ; regulation of cytosolic calcium ion concentration ; regulation of presynaptic cytosolic calcium ion concentration ; calcium ion export across plasma membrane ;
	Sources:Amigo / QuickGO
Orthologs
	492
	320707
	ENSG00000067842
	ENSMUSG00000031376
	Q16720
	n/a
	NM_001001344 ; NM_021949 ; NM_001388360 ; NM_001388361 ; NM_001388362 Contents References ; External links ; Further reading ;
	NM_177236 ; NM_001310537
	NP_001001344 ; NP_068768
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 02, 2023

Plasma membrane calcium-transporting ATPase 3(PMCA3) is an enzyme that in humans is encoded by the ATP2B3 gene.^[5]^[6]

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

Related Research Articles

<span class="mw-page-title-main">Calcium ATPase</span> Class of enzymes

Ca²⁺ ATPase is a form of P-ATPase that transfers calcium after a muscle has contracted. The two kinds of calcium ATPase are:

The plasma membrane Ca²⁺ ATPase (PMCA) is a transport protein in the plasma membrane of cells that functions as a calcium pump to remove calcium (Ca²⁺) from the cell. PMCA function is vital for regulating the amount of Ca²⁺ within all eukaryotic cells. There is a very large transmembrane electrochemical gradient of Ca²⁺ driving the entry of the ion into cells, yet it is very important that they maintain low concentrations of Ca²⁺ for proper cell signalling. Thus, it is necessary for cells to employ ion pumps to remove the Ca²⁺. The PMCA and the sodium calcium exchanger (NCX) are together the main regulators of intracellular Ca²⁺ concentrations. Since it transports Ca²⁺ into the extracellular space, the PMCA is also an important regulator of the calcium concentration in the extracellular space.

Plasma membrane calcium-transporting ATPase 4 is an enzyme that in humans is encoded by the ATP2B4 gene.

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) also known as Calcium pump 1, is an enzyme that in humans is encoded by the ATP2A1 gene.

Plasma membrane calcium-transporting ATPase 1 also known as Plasma membrane calcium pump isoform 1 is a plasma membrane Ca²⁺
ATPase, an enzyme that in humans is encoded by the ATP2B1 gene. It's a transport protein, a translocase, a calcium pump EC 7.2.2.10.

V-type proton ATPase subunit B, kidney isoform is an enzyme that in humans is encoded by the ATP6V1B1 gene.

Plasma membrane calcium-transporting ATPase 2 is an enzyme that in humans is encoded by the ATP2B2 gene.

V-type proton ATPase subunit E 1 is an enzyme that in humans is encoded by the ATP6V1E1 gene.

Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene.

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an enzyme that in humans is encoded by the ATP2A3 gene.

V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.

V-type proton ATPase subunit C 1 is an enzyme that in humans is encoded by the ATP6V1C1 gene.

V-type proton ATPase 116 kDa subunit a isoform 1 is an enzyme that in humans is encoded by the ATP6V0A1 gene.

Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.

V-type proton ATPase catalytic subunit A is an enzyme that in humans is encoded by the ATP6V1A gene.

V-type proton ATPase subunit d 1 is an enzyme that in humans is encoded by the ATP6V0D1 gene.

V-type proton ATPase subunit G 2 is an enzyme that in humans is encoded by the ATP6V1G2 gene.

V-type proton ATPase subunit G 3 is an enzyme that in humans is encoded by the ATP6V1G3 gene.

V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.

V-type proton ATPase subunit e 1 is an enzyme that in humans is encoded by the ATP6V0E1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000067842 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031376 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wang MG, Yi H, Hilfiker H, Carafoli E, Strehler EE, McBride OW (Jun 1994). "Localization of two genes encoding plasma membrane Ca2+ ATPases isoforms 2 (ATP2B2) and 3 (ATP2B3) to human chromosomes 3p26→p25 and Xq28, respectively". Cytogenet Cell Genet. 67 (1): 41–5. doi:10.1159/000133794. PMID 8187550.
1 2 "Entrez Gene: ATP2B3 ATPase, Ca++ transporting, plasma membrane 3".

External links

Human ATP2B3 genome location and ATP2B3 gene details page in the UCSC Genome Browser .

Møller JV, Juul B, le Maire M (1996). "Structural organization, ion transport, and energy transduction of P-type ATPases". Biochim. Biophys. Acta. 1286 (1): 1–51. doi:10.1016/0304-4157(95)00017-8. PMID 8634322.
Strehler EE, Zacharias DA (2001). "Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps". Physiol. Rev. 81 (1): 21–50. doi:10.1152/physrev.2001.81.1.21. PMID 11152753. S2CID 9062253.
Strehler EE, Treiman M (2004). "Calcium pumps of plasma membrane and cell interior". Curr. Mol. Med. 4 (3): 323–35. doi:10.2174/1566524043360735. PMID 15101689.
Brandt P, Neve RL, Kammesheidt A, et al. (1992). "Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels". J. Biol. Chem. 267 (7): 4376–85. doi: 10.1016/S0021-9258(18)42846-3 . PMID 1531651.
Stauffer TP, Hilfiker H, Carafoli E, Strehler EE (1995). "Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes". J. Biol. Chem. 269 (50): 32022. doi: 10.1016/S0021-9258(18)31797-6 . PMID 7989379.
Stauffer TP, Hilfiker H, Carafoli E, Strehler EE (1994). "Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes". J. Biol. Chem. 268 (34): 25993–6003. doi: 10.1016/S0021-9258(19)74484-6 . PMID 8245032.
Brown BJ, Hilfiker H, DeMarco SJ, et al. (1996). "Primary structure of human plasma membrane Ca(2+)-ATPase isoform 3". Biochim. Biophys. Acta. 1283 (1): 10–3. doi: 10.1016/0005-2736(96)00108-3 . PMID 8765088.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Mallon AM, Platzer M, Bate R, et al. (2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Res. 10 (6): 758–75. doi:10.1101/gr.10.6.758. PMC 310879 . PMID 10854409.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Moreau R, Daoud G, Masse A, et al. (2004). "Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta". Mol. Reprod. Dev. 65 (3): 283–8. doi:10.1002/mrd.10303. PMID 12784250. S2CID 12811406.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Martin R, Harvey NC, Crozier SR, et al. (2007). "Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual". Bone. 40 (5): 1203–8. doi:10.1016/j.bone.2006.12.060. PMID 17336174.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000067842 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031376 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8187550-5] Wang MG, Yi H, Hilfiker H, Carafoli E, Strehler EE, McBride OW (Jun 1994). "Localization of two genes encoding plasma membrane Ca2+ ATPases isoforms 2 (ATP2B2) and 3 (ATP2B3) to human chromosomes 3p26→p25 and Xq28, respectively". Cytogenet Cell Genet. 67 (1): 41–5. doi:10.1159/000133794. PMID 8187550.

[entrez-6] 1 2 "Entrez Gene: ATP2B3 ATPase, Ca++ transporting, plasma membrane 3".

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ATP2B3

Contents

Related Research Articles

References

External links

Further reading