ATP2B3

Last updated
ATP2B3
Identifiers
Aliases ATP2B3 , CFAP39, CLA2, OPCA, PMCA3, PMCA3a, SCAX1, ATPase plasma membrane Ca2+ transporting 3
External IDs OMIM: 300014 MGI: 1347353 HomoloGene: 123775 GeneCards: ATP2B3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001001344
NM_021949
NM_001388360
NM_001388361
NM_001388362

Contents

NM_177236
NM_001310537

RefSeq (protein)

NP_001001344
NP_068768

n/a

Location (UCSC) Chr X: 153.52 – 153.58 Mb Chr X: 72.55 – 72.61 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Plasma membrane calcium-transporting ATPase 3(PMCA3) is an enzyme that in humans is encoded by the ATP2B3 gene. [5] [6]

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified. [6]

Related Research Articles

<span class="mw-page-title-main">Calcium ATPase</span> Class of enzymes

Ca2+ ATPase is a form of P-ATPase that transfers calcium after a muscle has contracted. The two kinds of calcium ATPase are:

Plasma membrane Ca<sup>2+</sup> ATPase Transport protein

The plasma membrane Ca2+ ATPase (PMCA) is a transport protein in the plasma membrane of cells that functions as a calcium pump to remove calcium (Ca2+) from the cell. PMCA function is vital for regulating the amount of Ca2+ within all eukaryotic cells. There is a very large transmembrane electrochemical gradient of Ca2+ driving the entry of the ion into cells, yet it is very important that they maintain low concentrations of Ca2+ for proper cell signalling. Thus, it is necessary for cells to employ ion pumps to remove the Ca2+. The PMCA and the sodium calcium exchanger (NCX) are together the main regulators of intracellular Ca2+ concentrations. Since it transports Ca2+ into the extracellular space, the PMCA is also an important regulator of the calcium concentration in the extracellular space.

<span class="mw-page-title-main">ATP2B4</span> Protein-coding gene in the species Homo sapiens

Plasma membrane calcium-transporting ATPase 4 is an enzyme that in humans is encoded by the ATP2B4 gene.

<span class="mw-page-title-main">ATP2A1</span> Protein-coding gene in the species Homo sapiens

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) also known as Calcium pump 1, is an enzyme that in humans is encoded by the ATP2A1 gene.

<span class="mw-page-title-main">ATP2B1</span> Protein-coding gene in the species Homo sapiens

Plasma membrane calcium-transporting ATPase 1 also known as Plasma membrane calcium pump isoform 1 is a plasma membrane Ca2+
ATPase
, an enzyme that in humans is encoded by the ATP2B1 gene. It's a transport protein, a translocase, a calcium pump EC 7.2.2.10.

<span class="mw-page-title-main">ATP6V1B1</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase subunit B, kidney isoform is an enzyme that in humans is encoded by the ATP6V1B1 gene.

<span class="mw-page-title-main">ATP2B2</span> Protein-coding gene in the species Homo sapiens

Plasma membrane calcium-transporting ATPase 2 is an enzyme that in humans is encoded by the ATP2B2 gene.

<span class="mw-page-title-main">ATP6V1E1</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase subunit E 1 is an enzyme that in humans is encoded by the ATP6V1E1 gene.

<span class="mw-page-title-main">ATP1B1</span> Protein-coding gene in the species Homo sapiens

Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene.

<span class="mw-page-title-main">ATP2A3</span> Protein-coding gene in the species Homo sapiens

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an enzyme that in humans is encoded by the ATP2A3 gene.

<span class="mw-page-title-main">ATP6V1B2</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.

<span class="mw-page-title-main">ATP6V1C1</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase subunit C 1 is an enzyme that in humans is encoded by the ATP6V1C1 gene.

<span class="mw-page-title-main">ATPase, H+ transporting, lysosomal V0 subunit a1</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase 116 kDa subunit a isoform 1 is an enzyme that in humans is encoded by the ATP6V0A1 gene.

<span class="mw-page-title-main">ATP1A4</span> Protein-coding gene in the species Homo sapiens

Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.

<span class="mw-page-title-main">ATP6V1A</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase catalytic subunit A is an enzyme that in humans is encoded by the ATP6V1A gene.

<span class="mw-page-title-main">ATP6V0D1</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase subunit d 1 is an enzyme that in humans is encoded by the ATP6V0D1 gene.

<span class="mw-page-title-main">ATP6V1G2</span>

V-type proton ATPase subunit G 2 is an enzyme that in humans is encoded by the ATP6V1G2 gene.

<span class="mw-page-title-main">ATP6V1G3</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase subunit G 3 is an enzyme that in humans is encoded by the ATP6V1G3 gene.

<span class="mw-page-title-main">ATP6V0B</span> Protein-coding gene in Homo sapiens

V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.

<span class="mw-page-title-main">ATP6V0E1</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase subunit e 1 is an enzyme that in humans is encoded by the ATP6V0E1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000067842 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031376 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wang MG, Yi H, Hilfiker H, Carafoli E, Strehler EE, McBride OW (Jun 1994). "Localization of two genes encoding plasma membrane Ca2+ ATPases isoforms 2 (ATP2B2) and 3 (ATP2B3) to human chromosomes 3p26→p25 and Xq28, respectively". Cytogenet Cell Genet. 67 (1): 41–5. doi:10.1159/000133794. PMID   8187550.
  6. 1 2 "Entrez Gene: ATP2B3 ATPase, Ca++ transporting, plasma membrane 3".

Further reading