DYRK3

DYRK3
Identifiers
Aliases	DYRK3 , DYRK5, RED, REDK, hYAK3-2, dual specificity tyrosine phosphorylation regulated kinase 3
External IDs	OMIM: 603497 MGI: 1330300 HomoloGene: 55762 GeneCards: DYRK3
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 206,635,536 bp [1] End 206,684,419 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 131,055,192 bp [2] End 131,066,077 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm vena cava stromal cell of endometrium mucosa of urinary bladder left ventricle gallbladder lactiferous duct smooth muscle tissue embryo gastric mucosa Top expressed in seminiferous tubule spermatid spermatocyte respiratory epithelium olfactory epithelium parotid gland facial motor nucleus bone marrow endocardial cushion Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity nucleotide binding ATP binding magnesium ion binding metal ion binding kinase activity protein serine/threonine kinase activity Cellular component nucleus nucleoplasm cytosol intracellular membrane-bounded organelle cytoplasm cytoplasmic stress granule pericentriolar material microtubule organizing center cytoskeleton nuclear speck Biological process erythrocyte differentiation protein phosphorylation peptidyl-tyrosine phosphorylation phosphorylation stress granule disassembly negative regulation of apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator regulation of cellular response to stress regulation of TORC1 signaling cell cycle nuclear speck organization cell division positive regulation of cell cycle G2/M phase transition organelle disassembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8444 226419 Ensembl ENSG00000143479 ENSMUSG00000016526 UniProt O43781 Q922Y0 RefSeq (mRNA) NM_001004023 NM_003582 NM_145508 RefSeq (protein) NP_001004023 NP_003573 NP_663483 Location (UCSC) Chr 1: 206.64 – 206.68 Mb Chr 1: 131.06 – 131.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity tyrosine-phosphorylation-regulated kinase 3 is an enzyme that in humans is encoded by the DYRK3 gene. ^{[5] [6]}

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. ^[6]

See also

• DYRK1A
• DYRK1B
• DYRK2

References

1. GRCh38: Ensembl release 89: ENSG00000143479 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000016526 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ, Joost HG (Nov 1998). "Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases". J Biol Chem. 273 (40): 25893–902. doi: 10.1074/jbc.273.40.25893 . PMID   9748265.
6. "Entrez Gene: DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Zhang D, Li K, Erickson-Miller CL, et al. (2005). "DYRK gene structure and erythroid-restricted features of DYRK3 gene expression". Genomics. 85 (1): 117–30. doi:10.1016/j.ygeno.2004.08.021. PMID   15607427.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Li K, Zhao S, Karur V, Wojchowski DM (2003). "DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival". J. Biol. Chem. 277 (49): 47052–60. doi: 10.1074/jbc.M205374200 . PMID   12356771.
• Lord KA, Creasy CL, King AG, et al. (2000). "REDK, a novel human regulatory erythroid kinase". Blood. 95 (9): 2838–46. doi:10.1182/blood.V95.9.2838.009k29_2838_2846. PMID   10779429.
• Xia J, Yang X, Ruan Q, et al. (1999). "[Molecular cloning and characterization of novel protein kinase gene DYRK3]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 15 (6): 327–32. PMID   9845759.