TESK2

TESK2
Identifiers
Aliases	TESK2 , testis-specific kinase 2, testis associated actin remodelling kinase 2
External IDs	OMIM: 604746 MGI: 2385204 HomoloGene: 5188 GeneCards: TESK2
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p34.1 Start 45,343,883 bp [1] End 45,491,163 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D1 Start 116,578,145 bp [2] End 116,663,153 bp [2]
RNA expression pattern Bgee Top expressed in prostate blood substantia nigra zone of skin small intestine corpus callosum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity nucleotide binding GO:0001948 protein binding ATP binding metal ion binding kinase activity protein serine/threonine kinase activity signal transducer activity Cellular component nucleoplasm nucleus cytoplasm nuclear body Biological process protein phosphorylation peptidyl-tyrosine phosphorylation focal adhesion assembly actin cytoskeleton organization spermatogenesis phosphorylation GO:0007243 intracellular signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10420	230661
Ensembl	ENSG00000070759	ENSMUSG00000033985
UniProt	Q96S53	Q8VCT9
RefSeq (mRNA)	NM_007170 NM_001320800	NM_146151
RefSeq (protein)	NP_001307729 NP_009101	NP_666263
Location (UCSC)	Chr 1: 45.34 – 45.49 Mb	Chr 4: 116.58 – 116.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity testis-specific protein kinase 2 is an enzyme that in humans is encoded by the TESK2 gene. ^{[5] [6]}

Function

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meiotic stages and/or early stages of spermiogenesis. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000070759 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033985 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Røsok O, Pedeutour F, Ree AH, Aasheim HC (October 1999). "Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis". Genomics. 61 (1): 44–54. doi:10.1006/geno.1999.5922. PMID   10512679.
6. "Entrez Gene: TESK2 testis-specific kinase 2".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Toshima JY, Toshima J, Watanabe T, Mizuno K (November 2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". The Journal of Biological Chemistry. 276 (46): 43471–81. doi: 10.1074/jbc.M104620200 . PMID   11555644.
• Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (August 2001). "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells". The Journal of Biological Chemistry. 276 (33): 31449–58. doi: 10.1074/jbc.M102988200 . PMID   11418599.