NLK

NLK
Identifiers
Aliases	NLK , nemo like kinase
External IDs	OMIM: 609476 MGI: 1201387 HomoloGene: 88836 GeneCards: NLK
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q11.2 Start 28,041,737 bp [1] End 28,196,381 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B5 Start 78,457,994 bp [2] End 78,588,199 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 endothelial cell retinal pigment epithelium parietal lobe superior frontal gyrus postcentral gyrus entorhinal cortex internal globus pallidus prefrontal cortex Top expressed in retinal pigment epithelium pineal gland prefrontal cortex medial ganglionic eminence habenula olfactory tubercle substantia nigra cumulus cell stria vascularis iris More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding transcription factor binding metal ion binding kinase activity protein binding ubiquitin protein ligase binding protein serine/threonine kinase activity SH2 domain binding ATP binding protein kinase activity magnesium ion binding MAP kinase activity Cellular component cytosol nucleoplasm nucleus cytoplasm Biological process phosphorylation protein stabilization Wnt signaling pathway transcription, DNA-templated MAPK cascade protein autophosphorylation transforming growth factor beta receptor signaling pathway Wnt signaling pathway, calcium modulating pathway regulation of transcription, DNA-templated negative regulation of Wnt signaling pathway protein phosphorylation peptidyl-threonine phosphorylation regulation of gene expression serine phosphorylation of STAT protein intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51701 18099 Ensembl ENSG00000087095 ENSMUSG00000017376 UniProt Q9UBE8 O54949 RefSeq (mRNA) NM_016231 NM_008702 RefSeq (protein) NP_057315 NP_032728 Location (UCSC) Chr 17: 28.04 – 28.2 Mb Chr 11: 78.46 – 78.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

For the airport in the South Pacific, see Norfolk Island Airport.

Serine/threonine protein kinase NLK is an enzyme that in humans is encoded by the NLK gene. ^{[5] [6] [7]} Its name is an abbreviation for Nemo-Like Kinase, Nemo (nmo) being the Drosophila ortholog of the mammalian NLK gene. ^[8] This enzyme is a member of the Mitogen-activated protein kinase (MAPK) family, although not explicitly designated as such (it does not even have a numbered MAPK code). It is a highly divergent, atypical member of the MAPK group, lacking most features so characteristic of most mitogen-activated protein kinases (e.g. it does not have the dual phosphorylation motifs of typical MAPKs, and is not phosphorylated by any known MAP2 kinases). Its activation mechanism and downstream targets are still not well characterized. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000087095 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017376 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brott BK, Pinsky BA, Erikson RL (Mar 1998). "Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus". Proc Natl Acad Sci U S A. 95 (3): 963–8. Bibcode:1998PNAS...95..963B. doi: 10.1073/pnas.95.3.963 . PMC   18639 . PMID   9448268.
6. Kehrer-Sawatzki H, Moschgath E, Maier C, Legius E, Elgar G, Krone W (Jul 2000). "Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts". Gene. 251 (1): 63–71. doi:10.1016/S0378-1119(00)00188-8. PMID   10863097.
7. "Entrez Gene: NLK nemo-like kinase".
8. Ishitani T, Ishitani S (January 2013). "Nemo-like kinase, a multifaceted cell signaling regulator". Cell. Signal. 25 (1): 190–7. doi:10.1016/j.cellsig.2012.09.017. PMID   23000342.
9. Coulombe P, Meloche S (August 2007). "Atypical mitogen-activated protein kinases: structure, regulation and functions". Biochim. Biophys. Acta. 1773 (8): 1376–87. doi: 10.1016/j.bbamcr.2006.11.001 . PMID   17161475.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Volorio S, Simon G, Repetto M, et al. (1999). "Sequencing analysis of forty-eight human image cDNA clones similar to Drosophila mutant protein". DNA Seq. 9 (5–6): 307–15. doi:10.3109/10425179809008469. PMID   10524757.
• Kortenjann M, Wehrle C, Nehls MC, Boehm T (2002). "Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes". Gene. 278 (1–2): 161–5. doi:10.1016/S0378-1119(01)00710-7. PMID   11707333.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID   12107411.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ishitani T, Kishida S, Hyodo-Miura J, et al. (2003). "The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling". Mol. Cell. Biol. 23 (1): 131–9. doi:10.1128/MCB.23.1.131-139.2003. PMC   140665 . PMID   12482967.
• Ishitani T, Ninomiya-Tsuji J, Matsumoto K (2003). "Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling". Mol. Cell. Biol. 23 (4): 1379–89. doi:10.1128/MCB.23.4.1379-1389.2003. PMC   141159 . PMID   12556497.
• Yasuda J, Tsuchiya A, Yamada T, et al. (2003). "Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells". Biochem. Biophys. Res. Commun. 308 (2): 227–33. doi:10.1016/S0006-291X(03)01343-3. PMID   12901858.
• Yasuda J, Yokoo H, Yamada T, et al. (2004). "Nemo-like kinase suppresses a wide range of transcription factors, including nuclear factor-kappaB". Cancer Sci. 95 (1): 52–7. doi: 10.1111/j.1349-7006.2004.tb03170.x . PMID   14720327. S2CID   29269901.
• Smit L, Baas A, Kuipers J, et al. (2004). "Wnt activates the Tak1/Nemo-like kinase pathway". J. Biol. Chem. 279 (17): 17232–40. doi: 10.1074/jbc.M307801200 . PMID   14960582.
• Kanei-Ishii C, Ninomiya-Tsuji J, Tanikawa J, et al. (2004). "Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK". Genes Dev. 18 (7): 816–29. doi:10.1101/gad.1170604. PMC   387421 . PMID   15082531.
• Kanei-Ishii C, Nomura T, Tanikawa J, et al. (2004). "Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation". J. Biol. Chem. 279 (43): 44582–9. doi: 10.1074/jbc.M407831200 . PMID   15308626.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kojima H, Sasaki T, Ishitani T, et al. (2005). "STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation". Proc. Natl. Acad. Sci. U.S.A. 102 (12): 4524–9. Bibcode:2005PNAS..102.4524K. doi: 10.1073/pnas.0500679102 . PMC   555521 . PMID   15764709.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Gohda J, Irisawa M, Tanaka Y, et al. (2007). "HTLV-1 Tax-induced NFkappaB activation is independent of Lys-63-linked-type polyubiquitination". Biochem. Biophys. Res. Commun. 357 (1): 225–30. doi:10.1016/j.bbrc.2007.03.125. PMID   17418100.