KLF11

KLF11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PO4
Identifiers
Aliases	KLF11 , FKLF, FKLF1, MODY7, TIEG2, Tieg3, Kruppel-like factor 11, Kruppel like factor 11
External IDs	OMIM: 603301 MGI: 2653368 HomoloGene: 2668 GeneCards: KLF11
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p25.1 Start 10,042,849 bp [1] End 10,054,836 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12 A1.3|12 8.49 cM Start 24,701,273 bp [2] End 24,712,788 bp [2]
RNA expression pattern Bgee Top expressed in secondary oocyte monocyte saphenous vein gastric mucosa amniotic fluid abdominal fat Body of pancreas subcutaneous adipose tissue skin of abdomen parietal pleura More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity DNA binding GO:0001948 protein binding metal ion binding nucleic acid binding GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol focal adhesion nuclear body Biological process positive regulation of apoptotic process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II regulation of transcription involved in G1/S transition of mitotic cell cycle transcription, DNA-templated negative regulation of cell population proliferation apoptotic process cellular response to peptide regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8462	194655
Ensembl	ENSG00000172059	ENSMUSG00000020653
UniProt	O14901	Q8K1S5
RefSeq (mRNA)	NM_001177716 NM_001177718 NM_003597	NM_178357
RefSeq (protein)	NP_001171187 NP_001171189 NP_003588	NP_848134
Location (UCSC)	Chr 2: 10.04 – 10.05 Mb	Chr 12: 24.7 – 24.71 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Krueppel-like factor 11 is a protein that in humans is encoded by the KLF11 gene. ^{[5] [6] [7]}

KLF11 is a mesoderm derived, zinc finger transcription factor in the Krüppel-like factor (KLF) family. It binds to SP1- like GC- rich sequences in epsilon and gamma globin gene promoters inhibiting cellular growth and causing apoptosis. In the regulation of genes, it is involved in cellular inflammation and differentiation, making it an essential factor in early embryonic development. This transcription factor binds to promoters of genes involved in cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism, specifically pancreatic beta cell function. Defects in KLF11 affect glucose metabolism, insulin transcription, insulin processing, and insulin secretion which cause type 2 diabetes in adults and maturity-onset diabetes of the young type 7. These types of diabetes are caused by KLF11 interacting with co-repressors in the pancreatic islet beta cells. KLF11 has recently been shown to be involved in endometriosis since it regulated the expression of extracellular matrix genes. Its absence in extracellular matrix genes created a more fibrogenic response by the tissue. This was proved by creating a “knockout” model. The experiment showed that the absence of KLF11 showed higher amounts of fibrosis indicating that it prevents the growth of endometriotic lesions and inhibits pathological scarring.

^{[8] [9] [10]}

Interactions

KLF11 has been shown to interact with SIN3A. ^{[11] [12]}

See also

• Krüppel-like factors
• Maturity onset diabetes of the young

References

1. GRCh38: Ensembl release 89: ENSG00000172059 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020653 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cook T, Gebelein B, Mesa K, Mladek A, Urrutia R (Oct 1998). "Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth". The Journal of Biological Chemistry. 273 (40): 25929–36. doi: 10.1074/jbc.273.40.25929 . PMID   9748269.
6. Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C (Nov 2000). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics. 70 (1): 93–101. doi:10.1006/geno.2000.6362. PMID   11087666.
7. "Entrez Gene: KLF11 Kruppel-like factor 11".
8. Daftary GS, Zheng Y, Tabbaa ZM, Schoolmeester JK, Gada RP, Grzenda AL, Mathison AJ, Keeney GL, Lomberk GA, Urrutia R (2013). "A novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis". PLOS ONE. 8 (3): e60165. Bibcode:2013PLoSO...860165D. doi: 10.1371/journal.pone.0060165 . PMC   3610699 . PMID   23555910.
9. Mathison A, Grzenda A, Lomberk G, Velez G, Buttar N, Tietz P, Hendrickson H, Liebl A, Xiong YY, Gores G, Fernandez-Zapico M, Larusso NF, Faubion W, Shah VH, Urrutia R (2013). "Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis". PLOS ONE. 8 (9): e75311. Bibcode:2013PLoSO...875311M. doi: 10.1371/journal.pone.0075311 . PMC   3775729 . PMID   24069400.
10. Spittau B, Krieglstein K (2012). "Klf10 and Klf11 as mediators of TGF-beta superfamily signaling". Cell and Tissue Research. 347 (1): 65–72. doi:10.1007/s00441-011-1186-6. PMID   21574058. S2CID   14295737.
11. Zhang JS, Moncrieffe MC, Kaczynski J, Ellenrieder V, Prendergast FG, Urrutia R (Aug 2001). "A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A". Molecular and Cellular Biology. 21 (15): 5041–9. doi:10.1128/MCB.21.15.5041-5049.2001. PMC   87230 . PMID   11438660.
12. Ellenrieder V, Zhang JS, Kaczynski J, Urrutia R (May 2002). "Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor". The EMBO Journal. 21 (10): 2451–60. doi:10.1093/emboj/21.10.2451. PMC   126002 . PMID   12006497.

Further reading

• Asano H, Li XS, Stamatoyannopoulos G (May 1999). "FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes". Molecular and Cellular Biology. 19 (5): 3571–9. doi:10.1128/MCB.19.5.3571. PMC   84149 . PMID   10207080.
• Zhang JS, Moncrieffe MC, Kaczynski J, Ellenrieder V, Prendergast FG, Urrutia R (Aug 2001). "A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A". Molecular and Cellular Biology. 21 (15): 5041–9. doi:10.1128/MCB.21.15.5041-5049.2001. PMC   87230 . PMID   11438660.
• Jia L, Young MF, Powell J, Yang L, Ho NC, Hotchkiss R, Robey PG, Francomano CA (Jan 2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID   11827452.
• Ellenrieder V, Zhang JS, Kaczynski J, Urrutia R (May 2002). "Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor". The EMBO Journal. 21 (10): 2451–60. doi:10.1093/emboj/21.10.2451. PMC   126002 . PMID   12006497.
• Ou XM, Chen K, Shih JC (May 2004). "Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene". The Journal of Biological Chemistry. 279 (20): 21021–8. doi: 10.1074/jbc.M312638200 . PMID   15024015.
• Ellenrieder V, Buck A, Harth A, Jungert K, Buchholz M, Adler G, Urrutia R, Gress TM (Aug 2004). "KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells". Gastroenterology. 127 (2): 607–20. doi:10.1053/j.gastro.2004.05.018. PMID   15300592.
• Cao S, Fernandez-Zapico ME, Jin D, Puri V, Cook TA, Lerman LO, Zhu XY, Urrutia R, Shah V (Jan 2005). "KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling". The Journal of Biological Chemistry. 280 (3): 1901–10. doi: 10.1074/jbc.M407941200 . PMID   15531587.
• Neve B, Fernandez-Zapico ME, Ashkenazi-Katalan V, Dina C, Hamid YH, Joly E, Vaillant E, Benmezroua Y, Durand E, Bakaher N, Delannoy V, Vaxillaire M, Cook T, Dallinga-Thie GM, Jansen H, Charles MA, Clément K, Galan P, Hercberg S, Helbecque N, Charpentier G, Prentki M, Hansen T, Pedersen O, Urrutia R, Melloul D, Froguel P (Mar 2005). "Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function". Proceedings of the National Academy of Sciences of the United States of America. 102 (13): 4807–12. doi: 10.1073/pnas.0409177102 . PMC   554843 . PMID   15774581.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Buck A, Buchholz M, Wagner M, Adler G, Gress T, Ellenrieder V (Nov 2006). "The tumor suppressor KLF11 mediates a novel mechanism in transforming growth factor beta-induced growth inhibition that is inactivated in pancreatic cancer". Molecular Cancer Research. 4 (11): 861–72. doi: 10.1158/1541-7786.MCR-06-0081 . PMID   17114344.
• Florez JC, Saxena R, Winckler W, Burtt NP, Almgren P, Bengtsson Boström K, Tuomi T, Gaudet D, Ardlie KG, Daly MJ, Altshuler D, Hirschhorn JN, Groop L (Dec 2006). "The Krüppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people". Diabetes. 55 (12): 3620–4. doi: 10.2337/db06-0867 . PMID   17130512.
• Spittau B, Wang Z, Boinska D, Krieglstein K (Jun 2007). "Functional domains of the TGF-beta-inducible transcription factor Tieg3 and detection of two putative nuclear localization signals within the zinc finger DNA-binding domain". Journal of Cellular Biochemistry. 101 (3): 712–22. doi:10.1002/jcb.21228. PMID   17252542. S2CID   9730806.
• Niu X, Perakakis N, Laubner K, Limbert C, Stahl T, Brendel MD, Bretzel RG, Seufert J, Päth G (Jul 2007). "Human Krüppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells". Diabetologia. 50 (7): 1433–41. doi: 10.1007/s00125-007-0667-3 . PMID   17479246.

External links

• KLF11+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.