IKZF3

Last updated
IKZF3
Identifiers
Aliases IKZF3 , AIO, AIOLOS, ZNFN1A3, IKAROS family zinc finger 3, IMD84
External IDs OMIM: 606221 MGI: 1342542 HomoloGene: 8269 GeneCards: IKZF3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_011771

RefSeq (protein)

NP_035901

Location (UCSC) Chr 17: 39.76 – 39.86 Mb Chr 11: 98.36 – 98.44 Mb
PubMed search [3] [4]
Wikidata
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Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene. [5] [6] [7]

Function

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described. [7]

Interactions

IKZF3 has been shown to interact with BCL2-like 1 [8] and HRAS. [9]

Related Research Articles

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<span class="mw-page-title-main">IKZF1</span> Protein-coding gene in the species Homo sapiens

DNA-binding protein Ikaros also known as Ikaros family zinc finger protein 1 is a protein that in humans is encoded by the IKZF1 gene.

<span class="mw-page-title-main">HDAC9</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">ZEB1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">IRF4</span> Protein-coding gene in the species Homo sapiens

Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene,. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. The expression of IRF4 is essential for the differentiation of T lymphocytes and B lymphocytes as well as certain myeloid cells. Dysregulation of the IRF4 gene can result in IRF4 functioning either as an oncogene or a tumor-suppressor, depending on the context of the modification.

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<span class="mw-page-title-main">IKZF2</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene. This protein is a member of Ikaros family of transcription factors.

<span class="mw-page-title-main">SAP18</span> Protein-coding gene in the species Homo sapiens

Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene.

<span class="mw-page-title-main">ZNF143</span> Protein-coding gene

Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.

<span class="mw-page-title-main">PTRF</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">IKZF4</span>

Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000161405 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018168 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K (April 1997). "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation". The EMBO Journal. 16 (8): 2004–13. doi:10.1093/emboj/16.8.2004. PMC   1169803 . PMID   9155026.
  6. Hosokawa Y, Maeda Y, Takahashi EI, Suzuki M, Seto M (November 1999). "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping". Genomics. 61 (3): 326–9. doi:10.1006/geno.1999.5949. PMID   10552935.
  7. 1 2 "Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)".
  8. Rebollo A, Ayllón V, Fleischer A, Martínez CA, Zaballos A (December 2001). "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis". Journal of Immunology. 167 (11): 6366–73. doi: 10.4049/jimmunol.167.11.6366 . PMID   11714801.
  9. Romero F, Martínez-A C, Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization". The EMBO Journal. 18 (12): 3419–30. doi:10.1093/emboj/18.12.3419. PMC   1171421 . PMID   10369681.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.