HOXB4

Last updated
HOXB4
Identifiers
Aliases HOXB4 , HOX-2.6, HOX2, HOX2F, homeobox B4
External IDs OMIM: 142965; MGI: 96185; HomoloGene: 32095; GeneCards: HOXB4; OMA:HOXB4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024015

NM_010459

RefSeq (protein)

NP_076920

NP_034589

Location (UCSC) Chr 17: 48.58 – 48.58 Mb Chr 11: 96.21 – 96.21 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene. [5] [6] [7]

Contents

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [7]

See also

Related Research Articles

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Homeobox protein Hox-B6 is a protein that in humans is encoded by the HOXB6 gene.

<span class="mw-page-title-main">HOXD10</span> Protein-coding gene in humans

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene.

<span class="mw-page-title-main">HOXA11</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene.

<span class="mw-page-title-main">HOXB5</span> Protein-coding gene in humans

Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.

<span class="mw-page-title-main">HOXC8</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.

<span class="mw-page-title-main">HOXB1</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene.

<span class="mw-page-title-main">HOXB2</span> Protein-coding gene in humans

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.

<span class="mw-page-title-main">HOXB9</span> Protein-coding gene in humans

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.

<span class="mw-page-title-main">HOXD3</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-D3 is a protein that in humans is encoded by the HOXD3 gene.

<span class="mw-page-title-main">HOXC4</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.

<span class="mw-page-title-main">HOXD9</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-D9 is a protein that in humans is encoded by the HOXD9 gene.

<span class="mw-page-title-main">HOXC6</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. Hox-C6 expression is highest in the fallopian tube and ovary. HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.

<span class="mw-page-title-main">HOXD4</span> Protein-coding gene

Homeobox protein Hox-D4 is a protein that in humans is encoded by the HOXD4 gene.

<span class="mw-page-title-main">HOXB8</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.

<span class="mw-page-title-main">HOXD12</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-D12 is a protein that in humans is encoded by the HOXD12 gene.

<span class="mw-page-title-main">HOXC9</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C9 is a protein that in humans is encoded by the HOXC9 gene.

<span class="mw-page-title-main">HOXC5</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C5 is a protein that in humans is encoded by the HOXC5 gene.

<span class="mw-page-title-main">HOXA6</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-A6 is a protein that in humans is encoded by the HOXA6 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182742 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038692 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
  6. Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID   1358459. S2CID   13370372.
  7. 1 2 "Entrez Gene: HOXB4 homeobox B4".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.