T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene. [5] [6]
The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.
TAL1 has been shown to interact with:
GATA-binding factor 1 or GATA-1 is the founding member of the GATA family of transcription factors. This protein is widely expressed throughout vertebrate species. In humans and mice, it is encoded by the GATA1 and Gata1 genes, respectively. These genes are located on the X chromosome in both species.
N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.
Transcription factor 3, also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 expression.
GATA2 or GATA-binding factor 2 is a transcription factor, i.e. a nuclear protein which regulates the expression of genes. It regulates many genes that are critical for the embryonic development, self-renewal, maintenance, and functionality of blood-forming, lympathic system-forming, and other tissue-forming stem cells. GATA2 is encoded by the GATA2 gene, a gene which often suffers germline and somatic mutations which lead to a wide range of familial and sporadic diseases, respectively. The gene and its product are targets for the treatment of these diseases.
LIM domain only 2, also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the LMO2 gene.
MAX is a gene that in humans encodes the MAX transcription factor.
LIM domain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene.
SCL-interrupting locus protein is a protein that in humans is encoded by the STIL gene.
Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.
T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.
ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.
Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.
Cardiotrophin-like cytokine factor 1 (CLCF1), also known as Novel Neurotrophin-1 (NNT-1) or B cell-stimulating factor-3 (BSF-3), is a protein that in humans is encoded by the CLCF1 gene.
Transcription factor AP-4 , also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.
Hairy/enhancer-of-split related with YRPW motif-like protein is a protein that in humans is encoded by the HEYL gene.
E74-like factor 2 (ELF2), formerly known as new Ets-related factor (NERF), is an ETS family transcription factor. In humans this protein is encoded by the ELF2 gene.
Zinc finger protein 91 homolog (mouse), ciliary neurotrophic factor transcription unit, also known as ZFP91-CNTF, is a human gene.
Ankyrin repeat and sterile alpha motif domain-containing protein 1B is a protein that in humans is encoded by the ANKS1B gene.
Helix-loop-helix protein 1 is a protein that in humans is encoded by the NHLH1 gene.
T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.