LMO1

LMO1
Identifiers
Aliases	LMO1 , RBTN1, RHOM1, TTG1, LIM domain only 1
External IDs	OMIM: 186921; MGI: 102812; HomoloGene: 48101; GeneCards: LMO1; OMA:LMO1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 8,224,309 bp [1] End 8,268,716 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 E3|7 57.21 cM Start 108,737,779 bp [2] End 108,774,414 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad vastus lateralis muscle muscle of thigh oocyte testicle retinal pigment epithelium secondary oocyte biceps brachii islet of Langerhans gastrocnemius muscle Top expressed in medial ganglionic eminence wall of urinary bladder mucosa of urinary bladder transitional epithelium of urinary bladder primary oocyte zygote lip secondary oocyte facial motor nucleus superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding Cellular component nucleus nucleoplasm Biological process regulation of T cell homeostatic proliferation negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4004 109594 Ensembl ENSG00000166407 ENSMUSG00000036111 UniProt P25800 Q924W9 RefSeq (mRNA) NM_001270428 NM_002315 NM_001302205 NM_001302206 NM_057173 NM_001382564 RefSeq (protein) NP_001257357 NP_002306 NP_001289134 NP_001289135 NP_476514 NP_001369493 Location (UCSC) Chr 11: 8.22 – 8.27 Mb Chr 7: 108.74 – 108.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene. ^{[5] [6] [7]}

LMO1 encodes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted. ^[7]

Interactions

LMO1 has been shown to interact with GATA3 ^{[8] [9]} and TAL1. ^{[10] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000166407 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036111 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (June 1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13". Proc Natl Acad Sci U S A. 88 (10): 4367–71. Bibcode:1991PNAS...88.4367B. doi: 10.1073/pnas.88.10.4367 . PMC   51660 . PMID   2034676.
6. McGuire EA, Davis AR, Korsmeyer SJ (March 1991). "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells". Blood. 77 (3): 599–606. doi: 10.1182/blood.V77.3.599.599 . PMID   1703797.
7. "Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)".
8. Ono Y, Fukuhara N, Yoshie O (December 1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3". Mol. Cell. Biol. 18 (12): 6939–50. doi:10.1128/MCB.18.12.6939. ISSN   0270-7306. PMC   109277 . PMID   9819382.
9. Ono Y, Fukuhara N, Yoshie O (February 1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL". J. Biol. Chem. 272 (7): 4576–81. doi: 10.1074/jbc.272.7.4576 . ISSN   0021-9258. PMID   9020185.
10. Valge-Archer VE, Osada H, Warren A J, Forster A, Li J, Baer R, Rabbitts T H (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode:1994PNAS...91.8617V. doi: 10.1073/pnas.91.18.8617 . ISSN   0027-8424. PMC   44657 . PMID   8078932.
11. Wadman I, Li J, Bash R O, Forster A, Osada H, Rabbitts T H, Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. ISSN   0261-4189. PMC   395422 . PMID   7957052.

Further reading

• Foroni L, Boehm T, White L, et al. (1992). "The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development". J. Mol. Biol. 226 (3): 747–61. doi:10.1016/0022-2836(92)90630-3. PMID   1507224.
• Boehm T, Spillantini MG, Sofroniew MV, et al. (1991). "Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression". Oncogene. 6 (5): 695–703. PMID   2052354.
• Chen Q, Cheng JT, Tasi LH, et al. (1990). "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein". EMBO J. 9 (2): 415–24. doi:10.1002/j.1460-2075.1990.tb08126.x. PMC   551682 . PMID   2303035.
• Boehm T, Greenberg JM, Buluwela L, et al. (1990). "An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs". EMBO J. 9 (3): 857–68. doi:10.1002/j.1460-2075.1990.tb08183.x. PMC   551746 . PMID   2311586.
• McGuire EA, Hockett RD, Pollock KM, et al. (1989). "The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein". Mol. Cell. Biol. 9 (5): 2124–32. doi:10.1128/MCB.9.5.2124. PMC   363006 . PMID   2501659.
• Boehm T, Baer R, Lavenir I, et al. (1988). "The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15". EMBO J. 7 (2): 385–94. doi:10.1002/j.1460-2075.1988.tb02825.x. PMC   454331 . PMID   3259177.
• Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC   395422 . PMID   7957052.
• Valge-Archer VE, Osada H, Warren AJ, et al. (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode:1994PNAS...91.8617V. doi: 10.1073/pnas.91.18.8617 . PMC   44657 . PMID   8078932.
• Arber S, Caroni P (1996). "Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ". Genes Dev. 10 (3): 289–300. doi: 10.1101/gad.10.3.289 . PMID   8595880.
• Jurata LW, Kenny DA, Gill GN (1996). "Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11693–8. Bibcode:1996PNAS...9311693J. doi: 10.1073/pnas.93.21.11693 . PMC   38120 . PMID   8876198.
• Ono Y, Fukuhara N, Yoshie O (1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL". J. Biol. Chem. 272 (7): 4576–81. doi: 10.1074/jbc.272.7.4576 . PMID   9020185.
• Valge-Archer V, Forster A, Rabbitts TH (1999). "The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)". Oncogene. 17 (24): 3199–202. doi:10.1038/sj.onc.1202353. PMID   9872335. S2CID   9835264.
• Bao J, Talmage DA, Role LW, Gautier J (2000). "Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins". Development. 127 (2): 425–35. doi:10.1242/dev.127.2.425. PMID   10603358.
• Cichutek A, Brueckmann T, Seipel B, et al. (2001). "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)". Cytogenet. Cell Genet. 93 (3–4): 277–83. doi:10.1159/000056998. PMID   11528126. S2CID   25807985.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Lin YW, Deveney R, Barbara M, et al. (2005). "OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1". Cancer Res. 65 (16): 7151–8. doi:10.1158/0008-5472.CAN-05-1400. PMC   1681523 . PMID   16103065.
• Saeki N, Kim DH, Usui T, et al. (2007). "GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling". Oncogene. 26 (45): 6488–98. doi:10.1038/sj.onc.1210475. PMID   17471240. S2CID   31245781.