LDB1

LDB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XJY, 2XJZ, 2YPA
Identifiers
Aliases	LDB1 , CLIM2, NLI, CLIM-2, LDB-1, LIM domain binding 1
External IDs	OMIM: 603451; MGI: 894762; HomoloGene: 2891; GeneCards: LDB1; OMA:LDB1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.32 Start 102,106,489 bp [1] End 102,120,368 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19 C3|19 38.75 cM Start 46,020,009 bp [2] End 46,033,653 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube ganglionic eminence left ovary skin of leg gastric mucosa skin of abdomen right ovary canal of the cervix sural nerve body of uterus Top expressed in ventricular zone tail of embryo lip genital tubercle thymus epiblast yolk sac superior frontal gyrus dentate gyrus of hippocampal formation granule cell neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein homodimerization activity transcription corepressor activity LIM domain binding chromatin binding protein self-association protein binding cis-regulatory region sequence-specific DNA binding enzyme binding transcription coregulator activity Cellular component transcription regulator complex nucleus cell leading edge nucleoplasm beta-catenin-TCF complex protein-containing complex Biological process hair follicle development transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery epithelial structure maintenance regulation of transcription, DNA-templated positive regulation of hemoglobin biosynthetic process somatic stem cell population maintenance regulation of transcription by RNA polymerase II gastrulation with mouth forming second cerebellar Purkinje cell differentiation regulation of DNA-templated transcription, elongation head development histone H3-K4 acetylation Wnt signaling pathway transcription by RNA polymerase II transcription, DNA-templated cerebellum development negative regulation of erythrocyte differentiation multicellular organism development neuron differentiation anterior/posterior axis specification cellular component assembly negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of cell adhesion regulation of focal adhesion assembly regulation of cell migration regulation of kinase activity regulation of hematopoietic stem cell differentiation negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8861 16825 Ensembl ENSG00000198728 ENSMUSG00000025223 UniProt Q86U70 P70662 RefSeq (mRNA) NM_001113407 NM_003893 NM_001321612 NM_001113408 NM_010697 NM_001360336 RefSeq (protein) NP_001106878 NP_001308541 NP_003884 NP_001106879 NP_034827 NP_001347265 Location (UCSC) Chr 10: 102.11 – 102.12 Mb Chr 19: 46.02 – 46.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

LIM domain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene. ^{[5] [6] [7]}

Interactions

LDB1 has been shown to interact with other proteins such as LMO4, ^{[8] [9]} TCF3, ^[10] TAL1 ^[10] and CBFA2T3. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000198728 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025223 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yamashita T, Agulnick AD, Copeland NG, Gilbert DJ, Jenkins NA, Westphal H (Apr 1998). "Genomic structure and chromosomal localization of the mouse LIM domain-binding protein 1 gene, Ldb1". Genomics. 48 (1): 87–92. doi:10.1006/geno.1997.5163. PMID   9503020.
6. Semina EV, Altherr MR, Murray JC (Dec 1998). "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI". Mamm Genome. 9 (11): 921–4. doi:10.1007/s003359900899. PMID   9799849. S2CID   28813194.
7. "Entrez Gene: LDB1 LIM domain binding 1".
8. Sutherland KD, Visvader Jane E, Choong David Y H, Sum Eleanor Y M, Lindeman Geoffrey J, Campbell Ian G (Oct 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1): 155–8. doi: 10.1002/ijc.11343 . ISSN   0020-7136. PMID   12925972. S2CID   20908722.
9. Deane JE, Mackay Joel P, Kwan Ann H Y, Sum Eleanor Y M, Visvader Jane E, Matthews Jacqueline M (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. 22 (9): 2224–33. doi:10.1093/emboj/cdg196. ISSN   0261-4189. PMC   156068 . PMID   12727888.
10. Goardon N, Lambert Julie A, Rodriguez Patrick, Nissaire Philippe, Herblot Sabine, Thibault Pierre, Dumenil Dominique, Strouboulis John, Romeo Paul-Henri, Hoang Trang (Jan 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. ISSN   0261-4189. PMC   1383517 . PMID   16407974.

Further reading

• Osada H, Grutz GG, Axelson H, et al. (1997). "LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1". Leukemia. 11 (Suppl 3): 307–12. PMID   9209374.
• Wadman IA, Osada H, Grütz GG, et al. (1997). "The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins". EMBO J. 16 (11): 3145–57. doi:10.1093/emboj/16.11.3145. PMC   1169933 . PMID   9214632.
• Jurata LW, Gill GN (1997). "Functional analysis of the nuclear LIM domain interactor NLI". Mol. Cell. Biol. 17 (10): 5688–98. doi:10.1128/MCB.17.10.5688. PMC   232417 . PMID   9315627.
• Visvader JE, Mao X, Fujiwara Y, et al. (1998). "The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13707–12. Bibcode:1997PNAS...9413707V. doi: 10.1073/pnas.94.25.13707 . PMC   28370 . PMID   9391090.
• Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors". J. Biol. Chem. 273 (6): 3152–7. doi: 10.1074/jbc.273.6.3152 . PMID   9452425.
• Kenny DA, Jurata LW, Saga Y, Gill GN (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11257–62. Bibcode:1998PNAS...9511257K. doi: 10.1073/pnas.95.19.11257 . PMC   21629 . PMID   9736723.
• Valge-Archer V, Forster A, Rabbitts TH (1999). "The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)". Oncogene. 17 (24): 3199–202. doi:10.1038/sj.onc.1202353. PMID   9872335. S2CID   9835264.
• Ueki N, Seki N, Yano K, et al. (1999). "Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2". J. Hum. Genet. 44 (2): 112–5. doi: 10.1007/s100380050120 . PMID   10083735.
• Drechsler M, Schumacher V, Friedrich S, et al. (2000). "Genomic structure, alternative transcripts and chromosome location of the human LIM domain binding protein 1 gene LDB1". Cytogenet. Cell Genet. 87 (1–2): 119–24. doi:10.1159/000015377. PMID   10640831. S2CID   23735189.
• Dreyer SD, Morello R, German MS, et al. (2000). "LMX1B transactivation and expression in nail-patella syndrome". Hum. Mol. Genet. 9 (7): 1067–74. doi: 10.1093/hmg/9.7.1067 . PMID   10767331.
• Sum EY, Peng B, Yu X, et al. (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi: 10.1074/jbc.M110603200 . PMID   11751867.
• Ostendorff HP, Peirano RI, Peters MA, et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature. 416 (6876): 99–103. Bibcode:2002Natur.416...99O. doi:10.1038/416099a. PMID   11882901. S2CID   4426785.
• Deane JE, Visvader JE, Mackay JP, Matthew JM (2003). "1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex". J. Biomol. NMR. 23 (2): 165–6. doi:10.1023/A:1016363414644. PMID   12153047. S2CID   30891765.
• Chen L, Segal D, Hukriede NA, et al. (2002). "Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14320–5. Bibcode:2002PNAS...9914320C. doi: 10.1073/pnas.212532399 . PMC   137882 . PMID   12381786.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• van Meyel DJ, Thomas JB, Agulnick AD (2003). "Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo". Development. 130 (9): 1915–25. doi:10.1242/dev.00389. PMID   12642495. S2CID   6211268.
• Deane JE, Mackay JP, Kwan AH, et al. (2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. 22 (9): 2224–33. doi:10.1093/emboj/cdg196. PMC   156068 . PMID   12727888.
• Marini M, Bongers EM, Cusano R, et al. (2004). "Confirmation of CLIM2/LMX1B interaction by yeast two-hybrid screening and analysis of its involvement in nail-patella syndrome". Int. J. Mol. Med. 12 (1): 79–82. doi:10.3892/ijmm.12.1.79. PMID   12792813.