LMO4

LMO4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L4Z
Identifiers
Aliases	LMO4 , LIM domain only 4
External IDs	OMIM: 603129 MGI: 109360 HomoloGene: 4927 GeneCards: LMO4
Gene location (Human)
Chr.	Chromosome 1 (human)
End	87,348,923 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	144,205,220 bp
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity ; • metal ion binding ; • GO:0001948 protein binding ; • GO:0001158 cis-regulatory region sequence-specific DNA binding ; • transcription factor binding ;
Cellular component	• transcription regulator complex ; • cell leading edge ;
Biological process	• regulation of transcription, DNA-templated ; • ventricular septum development ; • spinal cord association neuron differentiation ; • thymus development ; • negative regulation of protein-containing complex assembly ; • transcription, DNA-templated ; • ventral spinal cord interneuron differentiation ; • regulation of cell activation ; • spinal cord motor neuron differentiation ; • regulation of cell fate specification ; • positive regulation of transcription by RNA polymerase II ; • neural tube closure ; • transcription by RNA polymerase II ; • positive regulation of kinase activity ; • regulation of cell migration ;
	Sources:Amigo / QuickGO
Orthologs
	8543
	16911
	ENSG00000143013
	ENSMUSG00000028266
	P61968
	P61969
	NM_006769 ; NM_001369491
	NM_001161769 ; NM_001161770 ; NM_010723
	NP_006760 ; NP_001356420
	NP_001155241 ; NP_001155242 ; NP_034853
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 08, 2021

LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.^[5]

LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple ATTT motifs in the 3' region. A variant transcript missing a portion of the 5' region has been identified but cannot be confirmed because of the GC-rich nature of the region.^[5]

Interactions

LMO4 has been shown to interact with LDB1,^[6]^[7] RBBP8 ^[6]^[8] and BRCA1.^[6]^[8]

Related Research Articles

T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.

Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene.

LIM domain only 2, also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the LMO2 gene.

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.

C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.

LIM domain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene.

RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.

LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.

Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.

LIM domain only protein 7 is a protein that in humans is encoded by the LMO7 gene.

Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene. PEG3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction. PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.

LIM/homeobox protein Lhx6 is a protein that in humans is encoded by the LHX6 gene.

General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.

LIM domain-binding protein 2 is a protein that in humans is encoded by the LDB2 gene.

E74-like factor 2 (ELF2), formerly known as new Ets-related factor (NERF), is an ETS family transcription factor. In humans this protein is encoded by the ELF2 gene.

Helix-loop-helix protein 1 is a protein that in humans is encoded by the NHLH1 gene.

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.

Early growth response protein 4 (EGR-4), also known as AT133, is a protein that in humans is encoded by the EGR4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143013 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028266 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: LMO4 LIM domain only 4".
1 2 3 Sutherland, Kate D; Visvader Jane E; Choong David Y H; Sum Eleanor Y M; Lindeman Geoffrey J; Campbell Ian G (Oct 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1): 155–8. doi: 10.1002/ijc.11343 . ISSN 0020-7136. PMID 12925972.
↑ Deane, Janet E; Mackay Joel P; Kwan Ann H Y; Sum Eleanor Y M; Visvader Jane E; Matthews Jacqueline M (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. 22 (9): 2224–33. doi:10.1093/emboj/cdg196. ISSN 0261-4189. PMC 156068 . PMID 12727888.
1 2 Sum, Eleanor Y M; Peng Benjamin; Yu Xin; Chen Junjie; Byrne Jennifer; Lindeman Geoffrey J; Visvader Jane E (Mar 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi: 10.1074/jbc.M110603200 . ISSN 0021-9258. PMID 11751867.

Kenny DA, Jurata LW, Saga Y, Gill GN (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11257–62. Bibcode:1998PNAS...9511257K. doi: 10.1073/pnas.95.19.11257 . PMC 21629 . PMID 9736723.
Racevskis J, Dill A, Sparano JA, Ruan H (1999). "Molecular cloning of LMO41, a new human LIM domain gene". Biochim. Biophys. Acta. 1445 (1): 148–53. doi:10.1016/s0167-4781(99)00037-8. PMID 10209267.
Tse E, Grutz G, Garner AA, et al. (2000). "Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping". Mamm. Genome. 10 (11): 1089–94. doi:10.1007/s003359901167. PMID 10556429. S2CID 19479121.
Sum EY, Peng B, Yu X, et al. (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi: 10.1074/jbc.M110603200 . PMID 11751867.
Deane JE, Visvader JE, Mackay JP, Matthew JM (2003). "1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex". J. Biomol. NMR. 23 (2): 165–6. doi:10.1023/A:1016363414644. PMID 12153047. S2CID 30891765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Vu D, Marin P, Walzer C, et al. (2003). "Transcription regulator LMO4 interferes with neuritogenesis in human SH-SY5Y neuroblastoma cells". Brain Res. Mol. Brain Res. 115 (2): 93–103. doi:10.1016/S0169-328X(03)00119-0. PMID 12877980.
Manetopoulos C, Hansson A, Karlsson J, et al. (2003). "The LIM-only protein LMO4 modulates the transcriptional activity of HEN1". Biochem. Biophys. Res. Commun. 307 (4): 891–9. doi:10.1016/S0006-291X(03)01298-1. PMID 12878195.
Sutherland KD, Visvader JE, Choong DY, et al. (2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1): 155–8. doi: 10.1002/ijc.11343 . PMID 12925972.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Novotny-Diermayr V, Lin B, Gu L, Cao X (2005). "Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction". J. Biol. Chem. 280 (13): 12747–57. doi: 10.1074/jbc.M500175200 . PMID 15677447.
Sun T, Patoine C, Abu-Khalil A, et al. (2005). "Early asymmetry of gene transcription in embryonic human left and right cerebral cortex". Science. 308 (5729): 1794–8. Bibcode:2005Sci...308.1794S. doi:10.1126/science.1110324. PMC 2756725 . PMID 15894532.
Sum EY, Segara D, Duscio B, et al. (2005). "Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7659–64. Bibcode:2005PNAS..102.7659S. doi: 10.1073/pnas.0502990102 . PMC 1140463 . PMID 15897450.
Jeffries CM, Graham SC, Stokes PH, et al. (2007). "Stabilization of a binary protein complex by intein-mediated cyclization". Protein Sci. 15 (11): 2612–8. doi:10.1110/ps.062377006. PMC 2242402 . PMID 17001033.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143013 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028266 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: LMO4 LIM domain only 4".

[pmid12925972-6] 1 2 3 Sutherland, Kate D; Visvader Jane E; Choong David Y H; Sum Eleanor Y M; Lindeman Geoffrey J; Campbell Ian G (Oct 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1): 155–8. doi: 10.1002/ijc.11343 . ISSN 0020-7136. PMID 12925972.

[pmid12727888-7] Deane, Janet E; Mackay Joel P; Kwan Ann H Y; Sum Eleanor Y M; Visvader Jane E; Matthews Jacqueline M (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. 22 (9): 2224–33. doi:10.1093/emboj/cdg196. ISSN 0261-4189. PMC 156068 . PMID 12727888.

[pmid11751867-8] 1 2 Sum, Eleanor Y M; Peng Benjamin; Yu Xin; Chen Junjie; Byrne Jennifer; Lindeman Geoffrey J; Visvader Jane E (Mar 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi: 10.1074/jbc.M110603200 . ISSN 0021-9258. PMID 11751867.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

LMO4

Contents

Interactions

Related Research Articles

References

Further reading