LMO4

LMO4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L4Z
Identifiers
Aliases	LMO4 , LIM domain only 4
External IDs	OMIM: 603129; MGI: 109360; HomoloGene: 4927; GeneCards: LMO4; OMA:LMO4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p22.3 Start 87,328,880 bp [1] End 87,348,923 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 H2|3 68.61 cM Start 143,894,291 bp [2] End 143,910,981 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in dorsolateral prefrontal cortex prefrontal cortex Brodmann area 46 superior frontal gyrus parietal lobe postcentral gyrus Brodmann area 9 frontal pole cingulate gyrus anterior cingulate cortex Top expressed in granulocyte genital tubercle cingulate gyrus superior frontal gyrus visual cortex primary motor cortex primary visual cortex dentate gyrus of hippocampal formation granule cell CA3 field corneal stroma More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity metal ion binding protein binding cis-regulatory region sequence-specific DNA binding transcription factor binding Cellular component transcription regulator complex cell leading edge Biological process regulation of transcription, DNA-templated ventricular septum development spinal cord association neuron differentiation thymus development negative regulation of protein-containing complex assembly transcription, DNA-templated ventral spinal cord interneuron differentiation regulation of cell activation spinal cord motor neuron differentiation regulation of cell fate specification positive regulation of transcription by RNA polymerase II neural tube closure transcription by RNA polymerase II positive regulation of kinase activity regulation of cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8543 16911 Ensembl ENSG00000143013 ENSMUSG00000028266 UniProt P61968 P61969 RefSeq (mRNA) NM_006769 NM_001369491 NM_001161769 NM_001161770 NM_010723 RefSeq (protein) NP_006760 NP_001356420 NP_001155241 NP_001155242 NP_034853 Location (UCSC) Chr 1: 87.33 – 87.35 Mb Chr 3: 143.89 – 143.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene. ^[5]

LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple ATTT motifs in the 3' region. A variant transcript missing a portion of the 5' region has been identified but cannot be confirmed because of the GC-rich nature of the region. ^[5]

Clinical Significance

LMO4 has garnered significant attention for its involvement in cancer, particularly breast cancer. ^[6] It is overexpressed in a substantial percentage of primary breast carcinomas. ^[7] Studies have shown that LMO4 can promote the proliferation of mammary epithelial cells, inhibit their differentiation, and enhance cell invasion and motility, all of which are hallmarks of cancer progression.

Interactions

LMO4 has been shown to interact with LDB1, ^{[8] [9]} RBBP8 ^{[8] [10]} and BRCA1. ^{[8] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000143013 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028266 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: LMO4 LIM domain only 4".
6. Singh, Rajesh R.; Barnes, Christopher J.; Talukder, Amjad H.; Fuqua, Suzanne A.W.; Kumar, Rakesh (2005-11-15). "Negative Regulation of Estrogen Receptor α Transactivation Functions by LIM Domain Only 4 Protein" . Cancer Research. 65 (22): 10594–10601. doi:10.1158/0008-5472.CAN-05-2268. ISSN   0008-5472.
7. Sum, Eleanor Y. M.; Segara, Davendra; Duscio, Belinda; Bath, Mary L.; Field, Andrew S.; Sutherland, Robert L.; Lindeman, Geoffrey J.; Visvader, Jane E. (2005-05-24). "Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer". Proceedings of the National Academy of Sciences. 102 (21): 7659–7664. doi:10.1073/pnas.0502990102. ISSN   0027-8424. PMC   1140463 .
8. Sutherland, Kate D; Visvader Jane E; Choong David Y H; Sum Eleanor Y M; Lindeman Geoffrey J; Campbell Ian G (Oct 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1): 155–8. doi: 10.1002/ijc.11343 . ISSN   0020-7136. PMID   12925972.
9. Deane, Janet E; Mackay Joel P; Kwan Ann H Y; Sum Eleanor Y M; Visvader Jane E; Matthews Jacqueline M (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. 22 (9): 2224–33. doi:10.1093/emboj/cdg196. ISSN   0261-4189. PMC   156068 . PMID   12727888.
10. Sum, Eleanor Y M; Peng Benjamin; Yu Xin; Chen Junjie; Byrne Jennifer; Lindeman Geoffrey J; Visvader Jane E (Mar 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi: 10.1074/jbc.M110603200 . ISSN   0021-9258. PMID   11751867.

Further reading

• Kenny DA, Jurata LW, Saga Y, Gill GN (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11257–62. Bibcode:1998PNAS...9511257K. doi: 10.1073/pnas.95.19.11257 . PMC   21629 . PMID   9736723.
• Racevskis J, Dill A, Sparano JA, Ruan H (1999). "Molecular cloning of LMO41, a new human LIM domain gene". Biochim. Biophys. Acta. 1445 (1): 148–53. doi:10.1016/s0167-4781(99)00037-8. PMID   10209267.
• Tse E, Grutz G, Garner AA, et al. (2000). "Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping". Mamm. Genome. 10 (11): 1089–94. doi:10.1007/s003359901167. PMID   10556429. S2CID   19479121.
• Sum EY, Peng B, Yu X, et al. (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi: 10.1074/jbc.M110603200 . PMID   11751867.
• Deane JE, Visvader JE, Mackay JP, Matthew JM (2003). "1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex". J. Biomol. NMR. 23 (2): 165–6. doi:10.1023/A:1016363414644. PMID   12153047. S2CID   30891765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Vu D, Marin P, Walzer C, et al. (2003). "Transcription regulator LMO4 interferes with neuritogenesis in human SH-SY5Y neuroblastoma cells". Brain Res. Mol. Brain Res. 115 (2): 93–103. doi:10.1016/S0169-328X(03)00119-0. PMID   12877980.
• Manetopoulos C, Hansson A, Karlsson J, et al. (2003). "The LIM-only protein LMO4 modulates the transcriptional activity of HEN1". Biochem. Biophys. Res. Commun. 307 (4): 891–9. doi:10.1016/S0006-291X(03)01298-1. PMID   12878195.
• Sutherland KD, Visvader JE, Choong DY, et al. (2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1): 155–8. doi: 10.1002/ijc.11343 . PMID   12925972.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Novotny-Diermayr V, Lin B, Gu L, Cao X (2005). "Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction". J. Biol. Chem. 280 (13): 12747–57. doi: 10.1074/jbc.M500175200 . PMID   15677447.
• Sun T, Patoine C, Abu-Khalil A, et al. (2005). "Early asymmetry of gene transcription in embryonic human left and right cerebral cortex". Science. 308 (5729): 1794–8. Bibcode:2005Sci...308.1794S. doi:10.1126/science.1110324. PMC   2756725 . PMID   15894532.
• Sum EY, Segara D, Duscio B, et al. (2005). "Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7659–64. Bibcode:2005PNAS..102.7659S. doi: 10.1073/pnas.0502990102 . PMC   1140463 . PMID   15897450.
• Jeffries CM, Graham SC, Stokes PH, et al. (2007). "Stabilization of a binary protein complex by intein-mediated cyclization". Protein Sci. 15 (11): 2612–8. doi:10.1110/ps.062377006. PMC   2242402 . PMID   17001033.