ELF2

ELF2
Identifiers
Aliases	ELF2 , EU32, NERF, NERF-1A, NERF-1B, NERF-1a,b, NERF-2, E74 like ETS transcription factor 2
External IDs	MGI: 1916507; HomoloGene: 5006; GeneCards: ELF2; OMA:ELF2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q31.1 Start 139,028,112 bp [1] End 139,177,218 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 C Start 51,160,141 bp [2] End 51,248,084 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon epithelium of colon ganglionic eminence ventricular zone muscle of thigh Descending thoracic aorta right lung skin of thigh skin of hip ascending aorta Top expressed in spermatocyte spermatid seminiferous tubule ventricular zone zygote ganglionic eminence dermis Rostral migratory stream tail of embryo thymus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus cytosol nuclear body nucleoplasm Biological process regulation of transcription by RNA polymerase II positive regulation of transcription, DNA-templated cell differentiation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated regulation of B cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1998 69257 Ensembl ENSG00000109381 ENSMUSG00000037174 UniProt Q15723 Q9JHC9 RefSeq (mRNA) NM_001276457 NM_001276458 NM_001276459 NM_006874 NM_201999 NM_001331036 NM_001291059 NM_001291062 NM_001291063 NM_023502 NM_001356358 RefSeq (protein) NP_001263386 NP_001263387 NP_001263388 NP_001317965 NP_006865 NP_973728 NP_001358253 NP_001358265 NP_001358266 NP_001358267 NP_001358268 NP_001277988 NP_001277991 NP_001277992 NP_075991 NP_001343287 Location (UCSC) Chr 4: 139.03 – 139.18 Mb Chr 3: 51.16 – 51.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E74-like factor 2 (ELF2), formerly known as new Ets-related factor (NERF), is an ETS family transcription factor. ^[5] In humans this protein is encoded by the ELF2 gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000109381 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037174 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Oettgen P, Akbarali Y, Boltax J, Best J, Kunsch C, Libermann TA (September 1996). "Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1". Mol. Cell. Biol. 16 (9): 5091–106. doi:10.1128/MCB.16.9.5091. PMC   231510 . PMID   8756667.
6. "Entrez Gene: ELF2 E74-like factor 2 (ets domain transcription factor)".

Further reading

• Wilkinson DA, Neale GA, Mao S, et al. (1997). "Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia". Leukemia. 11 (1): 86–96. doi: 10.1038/sj.leu.2400516 . PMID   9001422.
• Mao S, Frank RC, Zhang J, et al. (1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Mol. Cell. Biol. 19 (5): 3635–44. doi:10.1128/mcb.19.5.3635. PMC   84165 . PMID   10207087.
• Christensen RA, Fujikawa K, Madore R, et al. (2002). "NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia". J. Cell. Biochem. 85 (3): 505–15. doi:10.1002/jcb.10148. PMID   11967990. S2CID   36902890.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". J. Biol. Chem. 279 (19): 19512–22. doi: 10.1074/jbc.M309074200 . PMID   14970218.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang B, Tomita Y, Qiu Y, et al. (2007). "E74-like factor 2 regulates valosin-containing protein expression". Biochem. Biophys. Res. Commun. 356 (3): 536–41. doi:10.1016/j.bbrc.2007.02.160. PMID   17368566.