CBX8

CBX8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3I91, 5EQ0, 2N4Q
Identifiers
Aliases	CBX8 , PC3, RC1, chromobox 8
External IDs	OMIM: 617354 MGI: 1353589 HomoloGene: 32199 GeneCards: CBX8
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q25.3 Start 79,792,132 bp [1] End 79,801,683 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 E2 Start 118,927,131 bp [2] End 118,931,795 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube stromal cell of endometrium ganglionic eminence right lobe of liver pituitary gland anterior pituitary right adrenal gland monocyte left ventricle left adrenal gland Top expressed in respiratory epithelium olfactory epithelium thymus proximal tubule yolk sac ganglionic eminence placenta cerebellar cortex seminal vesicula external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methylated histone binding protein binding single-stranded RNA binding ubiquitin-protein transferase activator activity Cellular component ubiquitin ligase complex nucleoplasm heterochromatin PRC1 complex PcG protein complex nucleus Biological process positive regulation of collagen biosynthetic process regulation of transcription, DNA-templated positive regulation of DNA repair negative regulation of transcription by RNA polymerase II transcription, DNA-templated positive regulation of cell population proliferation regulation of catalytic activity histone ubiquitination cellular response to hydrogen peroxide chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57332 30951 Ensembl ENSG00000141570 ENSMUSG00000025578 UniProt Q9HC52 Q9QXV1 RefSeq (mRNA) NM_020649 NM_013926 RefSeq (protein) NP_065700 NP_038954 Location (UCSC) Chr 17: 79.79 – 79.8 Mb Chr 11: 118.93 – 118.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene. ^{[5] [6]}

Interactions

CBX8 has been shown to interact with RING1 ^[7] and MLLT1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000141570 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025578 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bardos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS (Oct 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J Biol Chem. 275 (37): 28785–92. doi: 10.1074/jbc.M001835200 . PMID   10825164.
6. "Entrez Gene: CBX8 chromobox homolog 8 (Pc class homolog, Drosophila)".
7. Bárdos, J I; Saurin A J; Tissot C; Duprez E; Freemont P S (Sep 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J. Biol. Chem. 275 (37): 28785–92. doi: 10.1074/jbc.M001835200 . ISSN   0021-9258. PMID   10825164.
8. García-Cuéllar, M P; Zilles O; Schreiner S A; Birke M; Winkler T H; Slany R K (Jan 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi: 10.1038/sj.onc.1204108 . ISSN   0950-9232. PMID   11313972.

External links

• Human CBX8 genome location and CBX8 gene details page in the UCSC Genome Browser .

Further reading

• García-Cuéllar MP, Zilles O, Schreiner SA, et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi: 10.1038/sj.onc.1204108 . PMID   11313972.
• Hemenway CS, de Erkenez AC, Gould GC (2001). "The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias". Oncogene. 20 (29): 3798–805. doi:10.1038/sj.onc.1204478. PMID   11439343.
• Levine SS, Weiss A, Erdjument-Bromage H, et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Mol. Cell. Biol. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC   134016 . PMID   12167701.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi: 10.1111/j.1365-2443.2004.00705.x . PMID   15009096. S2CID   21813024.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi: 10.1016/j.cell.2005.08.029 . hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070.
• Dietrich N, Bracken AP, Trinh E, et al. (2007). "Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus". EMBO J. 26 (6): 1637–48. doi:10.1038/sj.emboj.7601632. PMC   1829390 . PMID   17332741.