PPP1CC

PPP1CC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IT6, 1JK7, 1U32, 2BCD, 2BDX, 4UT2, 4UT3
Identifiers
Aliases	PPP1CC , PP-1G, PP1C, PPP1G, protein phosphatase 1 catalytic subunit gamma
External IDs	OMIM: 176914 MGI: 3647492 HomoloGene: 100608 GeneCards: PPP1CC
Gene location (Human)
Chr.	Chromosome 12 (human)
End	110,742,939 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	122,175,273 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; right ventricle; ; parotid gland; ; secondary oocyte; ; superficial temporal artery; ; duodenum; ; sperm; ; oral cavity; ; germinal epithelium; ; tibia;
	Top expressed in
	spermatocyte; ; spermatid; ; olfactory bulb; ; ganglionic eminence; ; thymus; ; cerebellar cortex; ; bone marrow; ; ovary; ; uterus; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity ; protein domain specific binding ; protein N-terminus binding ; phosphatase activity ; protein-containing complex binding ; protein serine/threonine phosphatase activity ; metal ion binding ; protein phosphatase 1 binding ; protein C-terminus binding ; protein binding ; protein phosphatase binding ; hydrolase activity ; protein kinase binding ; lamin binding ; RNA binding ;
Cellular component	cytoplasm ; cytosol ; nuclear speck ; focal adhesion ; dendritic spine ; chromosome ; nucleoplasm ; mitochondrial outer membrane ; midbody ; PTW/PP1 phosphatase complex ; nucleolus ; mitochondrion ; cleavage furrow ; chromosome, centromeric region ; nucleus ; kinetochore ; protein phosphatase type 1 complex ; protein-containing complex ; presynapse ; postsynapse ; glutamatergic synapse ;
Biological process	regulation of nucleocytoplasmic transport ; rhythmic process ; protein dephosphorylation ; circadian regulation of gene expression ; cell division ; regulation of circadian rhythm ; neuron differentiation ; glycogen metabolic process ; cell cycle ; entrainment of circadian clock by photoperiod ; sister chromatid cohesion ; carbohydrate metabolic process ; positive regulation of glial cell proliferation ;
	Sources:Amigo / QuickGO
Orthologs
	5501
	434233
	ENSG00000186298
	ENSMUSG00000004455
	P36873
	P63087
	NM_001244974 ; NM_002710
	XM_006508415
	NP_001231903 ; NP_002701
	NP_038664
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 10, 2024

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.^[5]

Interactions

PPP1CC has been shown to interact with PPP1R15A,^[6]^[7] SMARCB1,^[6] TLX1 ^[8] and PPP1R9B.^[9]^[10]

Related Research Articles

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene.

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.

Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.

5'-AMP-activated protein kinase subunit beta-1 is an enzyme that in humans is encoded by the PRKAB1 gene.

5'-AMP-activated protein kinase subunit gamma-2 is an enzyme that in humans is encoded by the PRKAG2 gene.

Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.

Protein phosphatase 1 regulatory subunit 12A is an enzyme that in humans is encoded by the PPP1R12A gene.

Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.

Protein phosphatase 1 regulatory subunit 15A, also known as growth arrest and DNA damage-inducible protein (GADD34), is a protein that in humans is encoded by the PPP1R15A gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha is an enzyme that in humans is encoded by the PPP2R3A gene. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.

Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform is an enzyme that in humans is encoded by the PHKG1 gene.

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PP2BB) is an enzyme that in humans is encoded by the PPP3CB gene.

A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.

Coatomer subunit gamma is a protein that in humans is encoded by the COPG gene. It is one of seven proteins in the COPI coatomer complex that coats vesicles as they bud from the Golgi complex.

A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene.

Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene.

Protein phosphatase 1 regulatory subunit 12B is an enzyme that in humans is encoded by the PPP1R12B gene.

Protein phosphatase 1 regulatory subunit 7 is an enzyme that in humans is encoded by the PPP1R7 gene.

Protein phosphatase 1 regulatory subunit 14C is an enzyme that in humans is encoded by the PPP1R14C gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186298 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004455 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: PPP1CC Protein phosphatase 1, catalytic subunit, gamma isoform".
1 2 Wu DY, Tkachuck Douglas C, Roberson Rachel S, Schubach William H (Aug 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. 277 (31). United States: 27706–15. doi: 10.1074/jbc.M200955200 . ISSN 0021-9258. PMID 12016208.
↑ Connor JH, Weiser D C, Li S, Hallenbeck J M, Shenolikar S (Oct 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. 21 (20). United States: 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861 . PMID 11564868.
↑ Kawabe T, Muslin A J, Korsmeyer S J (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature . 385 (6615). ENGLAND: 454–8. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. ISSN 0028-0836. PMID 9009195. S2CID 608633.
↑ Hsieh-Wilson LC, Allen P B, Watanabe T, Nairn A C, Greengard P (Apr 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14). UNITED STATES: 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.
↑ Smith FD, Oxford G S, Milgram S L (Jul 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". J. Biol. Chem. 274 (28). UNITED STATES: 19894–900. doi: 10.1074/jbc.274.28.19894 . ISSN 0021-9258. PMID 10391935.

Van Eynde A, Wera S, Beullens M, et al. (1996). "Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing". J. Biol. Chem. 270 (47): 28068–74. doi: 10.1074/jbc.270.47.28068 . PMID 7499293.
Egloff MP, Cohen PT, Reinemer P, Barford D (1996). "Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate". J. Mol. Biol. 254 (5): 942–59. doi:10.1006/jmbi.1995.0667. PMID 7500362.
MacKintosh RW, Dalby KN, Campbell DG, et al. (1995). "The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1". FEBS Lett. 371 (3): 236–40. doi: 10.1016/0014-5793(95)00888-G . PMID 7556599. S2CID 42021604.
Norman SA, Mott DM (1994). "Molecular cloning and chromosomal localization of a human skeletal muscle PP-1 gamma 1 cDNA". Mamm. Genome. 5 (1): 41–5. doi:10.1007/BF00360567. PMID 8111128. S2CID 21566111.
Barker HM, Craig SP, Spurr NK, Cohen PT (1993). "Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2". Biochim. Biophys. Acta. 1178 (2): 228–33. doi:10.1016/0167-4889(93)90014-G. PMID 8394140.
Helps NR, Barker HM, Elledge SJ, Cohen PT (1996). "Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53". FEBS Lett. 377 (3): 295–300. doi: 10.1016/0014-5793(95)01347-4 . PMID 8549741. S2CID 3010008.
Saadat M, Nomoto K, Mizuno Y, et al. (1996). "Assignment of the gene encoding type 1 gamma protein phosphatase catalytic subunit (PPP1CC) on human, rat, and mouse chromosomes". Jpn. J. Hum. Genet. 41 (1): 159–65. doi: 10.1007/BF01892623 . PMID 8914631.
Armstrong CG, Browne GJ, Cohen P, Cohen PT (1998). "PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1". FEBS Lett. 418 (1–2): 210–4. doi:10.1016/S0014-5793(97)01385-9. PMID 9414128. S2CID 21169749.
Andreassen PR, Lacroix FB, Villa-Moruzzi E, Margolis RL (1998). "Differential subcellular localization of protein phosphatase-1 alpha, gamma1, and delta isoforms during both interphase and mitosis in mammalian cells". J. Cell Biol. 141 (5): 1207–15. doi:10.1083/jcb.141.5.1207. PMC 2137188 . PMID 9606212.
Ajuh PM, Browne GJ, Hawkes NA, et al. (2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex". Nucleic Acids Res. 28 (3): 678–86. doi:10.1093/nar/28.3.678. PMC 102561 . PMID 10637318.
Yang J, Hurley TD, DePaoli-Roach AA (2000). "Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif". J. Biol. Chem. 275 (30): 22635–44. doi: 10.1074/jbc.M003082200 . PMID 10807923.
Katayama H, Zhou H, Li Q, et al. (2002). "Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle". J. Biol. Chem. 276 (49): 46219–24. doi: 10.1074/jbc.M107540200 . PMID 11551964.
Patel KG, Liu C, Cameron PL, Cameron RS (2001). "Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1". J. Neurosci. 21 (20): 7954–68. doi: 10.1523/JNEUROSCI.21-20-07954.2001 . PMC 6763852 . PMID 11588169.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID 11790298. S2CID 14132033.
Jones JA, Hannun YA (2002). "Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid". J. Biol. Chem. 277 (18): 15530–8. doi: 10.1074/jbc.M111555200 . PMID 11856740.
Wu DY, Tkachuck DC, Roberson RS, Schubach WH (2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. 277 (31): 27706–15. doi: 10.1074/jbc.M200955200 . PMID 12016208.
Bharucha DC, Zhou M, Nekhai S, et al. (2002). "A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat". Virology. 296 (1): 6–16. doi: 10.1006/viro.2002.1438 . PMID 12036313.
Tan SL, Tareen SU, Melville MW, et al. (2002). "The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation". J. Biol. Chem. 277 (39): 36109–17. doi: 10.1074/jbc.M205109200 . PMID 12138106.
Eto M, Elliott E, Prickett TD, Brautigan DL (2003). "Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation". J. Biol. Chem. 277 (46): 44013–20. doi: 10.1074/jbc.M208035200 . PMID 12221103.
Ceulemans H, Vulsteke V, De Maeyer M, et al. (2003). "Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1". J. Biol. Chem. 277 (49): 47331–7. doi: 10.1074/jbc.M206838200 . PMID 12226088.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000186298 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004455 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: PPP1CC Protein phosphatase 1, catalytic subunit, gamma isoform".

[pmid12016208-6] 1 2 Wu DY, Tkachuck Douglas C, Roberson Rachel S, Schubach William H (Aug 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. 277 (31). United States: 27706–15. doi: 10.1074/jbc.M200955200 . ISSN 0021-9258. PMID 12016208.

[pmid11564868-7] Connor JH, Weiser D C, Li S, Hallenbeck J M, Shenolikar S (Oct 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. 21 (20). United States: 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861 . PMID 11564868.

[pmid9009195-8] Kawabe T, Muslin A J, Korsmeyer S J (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature . 385 (6615). ENGLAND: 454–8. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. ISSN 0028-0836. PMID 9009195. S2CID 608633.

[pmid10194355-9] Hsieh-Wilson LC, Allen P B, Watanabe T, Nairn A C, Greengard P (Apr 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14). UNITED STATES: 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.

[pmid10391935-10] Smith FD, Oxford G S, Milgram S L (Jul 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". J. Biol. Chem. 274 (28). UNITED STATES: 19894–900. doi: 10.1074/jbc.274.28.19894 . ISSN 0021-9258. PMID 10391935.

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PPP1CC

Contents

Interactions

Related Research Articles

References

Further reading