RYBP

RYBP
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3IXS
Identifiers
Aliases	RYBP , AAP1, DEDAF, YEAF1, APAP-1, RING1 and YY1 binding protein
External IDs	OMIM: 607535; MGI: 3648043; HomoloGene: 8159; GeneCards: RYBP; OMA:RYBP - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p13 Start 72,371,825 bp [1] End 72,446,621 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung cartilage tissue endothelial cell trabecular bone urethra Region I of hippocampus proper middle frontal gyrus optic nerve placenta inferior ganglion of vagus nerve n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding transcription corepressor activity metal ion binding Cellular component cytoplasm PcG protein complex nucleus nucleoplasm Biological process multicellular organism development histone H2A monoubiquitination regulation of transcription, DNA-templated transcription, DNA-templated apoptotic process negative regulation of transcription by RNA polymerase II negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of apoptotic process positive regulation of transcription, DNA-templated negative regulation of G0 to G1 transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23429 628746 Ensembl ENSG00000281766 ENSG00000163602 n/a UniProt Q8N488 n/a RefSeq (mRNA) NM_012234 XM_036158262 RefSeq (protein) NP_036366 n/a Location (UCSC) Chr 3: 72.37 – 72.45 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

RING1 and YY1-binding protein is a protein that in humans is encoded by the RYBP gene. ^{[4] [5]}

Interactions

RYBP has been shown to interact with:

• Abl gene, ^[6]
• CBX2, ^[4]
• Caspase 10, ^[7]
• E2F2, ^[8]
• E2F3, ^[8]
• Mdm2, ^[9]
• RING1, ^{[4] [10]} and
• YY1. ^[4]

References

1. ENSG00000163602 GRCh38: Ensembl release 89: ENSG00000281766, ENSG00000163602 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". The EMBO Journal. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC   1171420 . PMID   10369680.
5. "Entrez Gene: RYBP RING1 and YY1 binding protein".
6. Zhu J, Shore SK (Dec 1996). "c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein". Molecular and Cellular Biology. 16 (12): 7054–62. doi:10.1128/mcb.16.12.7054. PMC   231708 . PMID   8943360.
7. Zheng L, Schickling O, Peter ME, Lenardo MJ (Aug 2001). "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm". The Journal of Biological Chemistry. 276 (34): 31945–52. doi: 10.1074/jbc.M102799200 . PMID   11395500.
8. Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC   131074 . PMID   12411495.
9. Chen D, Zhang J, Li M, Rayburn ER, Wang H, Zhang R (Feb 2009). "RYBP stabilizes p53 by modulating MDM2". EMBO Reports. 10 (2): 166–72. doi:10.1038/embor.2008.231. PMC   2637313 . PMID   19098711.
10. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading

• Zhu J, Shore SK (Dec 1996). "c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein". Molecular and Cellular Biology. 16 (12): 7054–62. doi:10.1128/mcb.16.12.7054. PMC   231708 . PMID   8943360.
• Trimarchi JM, Fairchild B, Wen J, Lees JA (Feb 2001). "The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex". Proceedings of the National Academy of Sciences of the United States of America. 98 (4): 1519–24. doi: 10.1073/pnas.041597698 . PMC   29289 . PMID   11171983.
• Zheng L, Schickling O, Peter ME, Lenardo MJ (Aug 2001). "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm". The Journal of Biological Chemistry. 276 (34): 31945–52. doi: 10.1074/jbc.M102799200 . PMID   11395500.
• Sawa C, Yoshikawa T, Matsuda-Suzuki F, Deléhouzée S, Goto M, Watanabe H, Sawada J, Kataoka K, Handa H (Jun 2002). "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors". The Journal of Biological Chemistry. 277 (25): 22484–90. doi: 10.1074/jbc.M203060200 . PMID   11953439.
• Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC   131074 . PMID   12411495.
• Guelen L, Paterson H, Gäken J, Meyers M, Farzaneh F, Tavassoli M (Feb 2004). "TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells". Oncogene. 23 (5): 1153–65. doi: 10.1038/sj.onc.1207224 . PMID   14691460.
• Danen-van Oorschot AA, Voskamp P, Seelen MC, van Miltenburg MH, Bolk MW, Tait SW, Boesen-de Cock JG, Rohn JL, Borst J, Noteborn MH (May 2004). "Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing". Cell Death and Differentiation. 11 (5): 564–73. doi: 10.1038/sj.cdd.4401391 . PMID   14765135.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.