CBX2 (gene)

CBX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D9U, 3H91, 5EPK
Identifiers
Aliases	CBX2 , CDCA6, M33, SRXY5, chromobox 2
External IDs	OMIM: 602770; MGI: 88289; HomoloGene: 7256; GeneCards: CBX2; OMA:CBX2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q25.3 Start 79,778,148 bp [1] End 79,787,983 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 E2|11 83.33 cM Start 118,913,788 bp [2] End 118,922,096 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte gonad ganglionic eminence ventricular zone testicle right testis apex of heart left testis sperm stromal cell of endometrium Top expressed in gastrula mandibular prominence maxillary prominence secondary oocyte zygote primary oocyte somite genital tubercle tail of embryo epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding methylated histone binding chromatin binding protein binding Cellular component heterochromatin euchromatin PcG protein complex PRC1 complex nucleus nucleoplasm chromosome Biological process cell differentiation development of primary sexual characteristics sex differentiation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84733 12416 Ensembl ENSG00000173894 ENSMUSG00000025577 UniProt Q14781 P30658 RefSeq (mRNA) NM_005189 NM_032647 NM_007623 RefSeq (protein) NP_005180 NP_116036 NP_031649 Location (UCSC) Chr 17: 79.78 – 79.79 Mb Chr 11: 118.91 – 118.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chromobox protein homolog 2 is a protein that in humans is encoded by the CBX2 gene. ^{[5] [6] [7] [8]}

Interactions

CBX2 (gene) has been shown to interact with RYBP. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000173894 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025577 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gecz J, Gaunt SJ, Passage E, Burton RD, Cudrey C, Pearce JJ, Fontes M (Jul 1995). "Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25". Genomics. 26 (1): 130–3. doi:10.1016/0888-7543(95)80091-Y. PMID   7782071.
6. Chodak GW (Nov 1989). "Early detection and screening for prostatic cancer". Urology. 34 (4 Suppl): 10–2, discussion 46–56. doi:10.1016/0090-4295(89)90228-8. PMID   2477932.
7. "Entrez Gene: CBX2 chromobox homolog 2 (Pc class homolog, Drosophila)".
8. Ewen Callaway. "Girl with Y chromosome sheds light on maleness ", New Scientist , 2009-04-09. Retrieved on 2009-04-14.
9. García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC   1171420 . PMID   10369680.

External links

• Human CBX2 genome location and CBX2 gene details page in the UCSC Genome Browser .

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC   1171420 . PMID   10369680.
• Katoh-Fukui Y, Tsuchiya R, Shiroishi T, Nakahara Y, Hashimoto N, Noguchi K, Higashinakagawa T (1998). "Male-to-female sex reversal in M33 mutant mice". Nature. 393 (6686): 688–92. Bibcode:1998Natur.393..688K. doi:10.1038/31482. PMID   9641679. S2CID   4399183.
• Pearce JJ, Singh PB, Gaunt SJ (1992). "The mouse has a Polycomb-like chromobox gene". Development. 114 (4): 921–9. doi:10.1242/dev.114.4.921. PMID   1352241.