CBX2 (gene)

CBX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D9U, 3H91, 5EPK
Identifiers
Aliases	CBX2 , CDCA6, M33, SRXY5, chromobox 2
External IDs	OMIM: 602770 MGI: 88289 HomoloGene: 7256 GeneCards: CBX2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	79,787,983 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	118,922,096 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ganglionic eminence; ; sperm; ; stromal cell of endometrium; ; endothelial cell; ; left ventricle; ; sural nerve; ; bone marrow; ; amygdala; ; thymus;
	Top expressed in
	maxillary prominence; ; secondary oocyte; ; somite; ; abdominal wall; ; hand; ; primitive streak; ; internal carotid artery; ; medial ganglionic eminence; ; external carotid artery; ; hair follicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding ; methylated histone binding ; chromatin binding ; protein binding ;
Cellular component	heterochromatin ; euchromatin ; PcG protein complex ; PRC1 complex ; nucleus ; nucleoplasm ; chromosome ;
Biological process	cell differentiation ; development of primary sexual characteristics ; sex differentiation ; regulation of transcription, DNA-templated ; negative regulation of transcription by RNA polymerase II ; transcription, DNA-templated ; chromatin organization ;
	Sources:Amigo / QuickGO
Orthologs
	84733
	12416
	ENSG00000173894
	ENSMUSG00000025577
	Q14781
	P30658
	NM_005189 ; NM_032647
	NM_007623
	NP_005180 ; NP_116036
	NP_031649
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 06, 2022

Chromobox protein homolog 2 is a protein that in humans is encoded by the CBX2 gene.^[5]^[6]^[7]^[8]

Interactions

CBX2 (gene) has been shown to interact with RYBP.^[9]

Related Research Articles

Polycomb-group proteins are a family of protein complexes first discovered in fruit flies that can remodel chromatin such that epigenetic silencing of genes takes place. Polycomb-group proteins are well known for silencing Hox genes through modulation of chromatin structure during embryonic development in fruit flies. They derive their name from the fact that the first sign of a decrease in PcG function is often a homeotic transformation of posterior legs towards anterior legs, which have a characteristic comb-like set of bristles.

Chromobox protein homolog 1 is a protein that in humans is encoded by the CBX1 gene.

Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans.

Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene.

Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.

YY1 is a transcriptional repressor protein in humans that is encoded by the YY1 gene.

E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.

Polycomb protein EED is a protein that in humans is encoded by the EED gene.

E3 ubiquitin-protein ligase RING1 is an enzyme that in humans is encoded by the RING1 gene.

Polyhomeotic-like protein 1 is a protein that in humans is encoded by the PHC1 gene.

Polycomb group RING finger protein 2, PCGF2, also known as MEL18 or RNF110, is a protein that in humans is encoded by the PCGF2 gene.

Polyhomeotic-like protein 2 is a protein that in humans is encoded by the PHC2 gene.

Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene.

Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene. It is a highly conserved, non-histone protein part of the heterochromatin family. The protein itself is more commonly called HP1α. Heterochromatin protein-1 (HP1) has an N-terminal domain that acts on methylated lysines residues leading to epigenetic repression. The C-terminal of this protein has a chromo shadow-domain (CSD) that is responsible for homodimerizing, as well as interacting with a variety of chromatin-associated, non-histone proteins.

RING1 and YY1-binding protein is a protein that in humans is encoded by the RYBP gene.

Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.

Polycomb group RING finger protein 1, PCGF1, also known as NSPC1 or RNF68 is a RING finger domain protein that in humans is encoded by the PCGF1 gene.

M33 is a gene. It is a mammalian homologue of Drosophila Polycomb. It localises to euchromatin within interphase nuclei, but it is enriched within the centromeric heterochromatin of metaphase chromosomes. In mice, the official symbol of M33 gene styled Cbx2 and the official name chromobox 2 are maintained by the MGI. Also known as pc; MOD2. In human ortholog CBX2, synonyms CDCA6, M33, SRXY5 from orthology source HGNC. M33 was isolated by means of the structural similarity of its chromodomain. It contains a region of homology shared by Xenopus and Drosophila in the fifth exon. Polycomb genes in Drosophila mediate changes in higher-order chromatin structure to maintain the repressed state of developmentally regulated genes. It may also involved in the campomelic syndrome and neoplastic disorders linked to allele loss in this region. Disruption of the murine M33 gene, displayed posterior transformation of the sternal ribs and vertebral columns.

Chromobox homolog 7 is a protein that in humans is encoded by the CBX7 gene. The loss of CBX7 gene expression has been shown to correlate with a malignant form of thyroid cancer.

The human KDM2B gene encodes the protein lysine (K)-specific demethylase 2B.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000173894 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025577 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gecz J, Gaunt SJ, Passage E, Burton RD, Cudrey C, Pearce JJ, Fontes M (Jul 1995). "Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25". Genomics. 26 (1): 130–3. doi:10.1016/0888-7543(95)80091-Y. PMID 7782071.
↑ Chodak GW (Nov 1989). "Early detection and screening for prostatic cancer". Urology. 34 (4 Suppl): 10–2, discussion 46–56. doi:10.1016/0090-4295(89)90228-8. PMID 2477932.
↑ "Entrez Gene: CBX2 chromobox homolog 2 (Pc class homolog, Drosophila)".
↑ Ewen Callaway. "Girl with Y chromosome sheds light on maleness ", New Scientist , 2009-04-09. Retrieved on 2009-04-14.
↑ García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420 . PMID 10369680.

External links

Human CBX2 genome location and CBX2 gene details page in the UCSC Genome Browser .

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420 . PMID 10369680.
Katoh-Fukui Y, Tsuchiya R, Shiroishi T, Nakahara Y, Hashimoto N, Noguchi K, Higashinakagawa T (1998). "Male-to-female sex reversal in M33 mutant mice". Nature. 393 (6686): 688–92. Bibcode:1998Natur.393..688K. doi:10.1038/31482. PMID 9641679. S2CID 4399183.
Pearce JJ, Singh PB, Gaunt SJ (1992). "The mouse has a Polycomb-like chromobox gene". Development. 114 (4): 921–9. doi:10.1242/dev.114.4.921. PMID 1352241.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000173894 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025577 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7782071-5] Gecz J, Gaunt SJ, Passage E, Burton RD, Cudrey C, Pearce JJ, Fontes M (Jul 1995). "Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25". Genomics. 26 (1): 130–3. doi:10.1016/0888-7543(95)80091-Y. PMID 7782071.

[pmid2477932-6] Chodak GW (Nov 1989). "Early detection and screening for prostatic cancer". Urology. 34 (4 Suppl): 10–2, discussion 46–56. doi:10.1016/0090-4295(89)90228-8. PMID 2477932.

[entrez-7] "Entrez Gene: CBX2 chromobox homolog 2 (Pc class homolog, Drosophila)".

[8] Ewen Callaway. "Girl with Y chromosome sheds light on maleness ", New Scientist , 2009-04-09. Retrieved on 2009-04-14.

[pmid10369680-9] García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420 . PMID 10369680.

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CBX2 (gene)

Contents

Interactions

Related Research Articles

References

External links

Further reading