CENPK

CENPK
Identifiers
Aliases	CENPK , AF5alpha, CENP-K, P33, Solt, FKSG14, centromere protein K
External IDs	OMIM: 611502; MGI: 1926210; HomoloGene: 11035; GeneCards: CENPK; OMA:CENPK - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q12.3 Start 65,517,766 bp [1] End 65,563,168 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 D1 Start 104,365,119 bp [2] End 104,388,900 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte ventricular zone testicle secondary oocyte gonad ganglionic eminence thymus rectum appendix bone marrow Top expressed in fetal liver hematopoietic progenitor cell medial ganglionic eminence primitive streak genital tubercle vas deferens spermatid otic placode Paneth cell embryo maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytosol nucleus nucleoplasm chromosome, centromeric region chromosome kinetochore Biological process CENP-A containing chromatin assembly kinetochore assembly mitotic sister chromatid segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64105 60411 Ensembl ENSG00000123219 ENSMUSG00000021714 UniProt Q9BS16 Q9ESN5 RefSeq (mRNA) NM_001267038 NM_022145 NM_001349367 NM_001349368 NM_001349369 NM_021790 NM_181061 NM_001377093 NM_001377094 NM_001377095 RefSeq (protein) NP_001253967 NP_071428 NP_001336296 NP_001336297 NP_001336298 NP_068562 NP_851406 NP_001364022 NP_001364023 NP_001364024 Location (UCSC) Chr 5: 65.52 – 65.56 Mb Chr 13: 104.37 – 104.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centromere protein K is a protein that in humans is encoded by the CENPK gene. ^{[5] [6]}

Interactions

CENPK has been shown to interact with SOX6. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000123219 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021714 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Taki T, Hayashi Y, Taniwaki M, Seto M, Ueda R, Hanada R, Suzukawa K, Yokota J, Morishita K (Nov 1996). "Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia". Oncogene. 13 (10): 2121–30. PMID   8950979.
6. "Entrez Gene: CENPK centromere protein K".
7. Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters. 481 (2): 147–51. doi: 10.1016/S0014-5793(00)01987-6 . PMID   10996314. S2CID   20831354.

External links

• Human CENPK genome location and CENPK gene details page in the UCSC Genome Browser .

Further reading

• Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (Jun 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–84. doi: 10.1111/j.1365-2443.2006.00969.x . PMID   16716197. S2CID   45931410.
• Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID   16622420. S2CID   26974412.
• Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi:10.1038/ncb1397. PMID   16622419. S2CID   205286556.
• Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi: 10.1111/j.1365-2443.2004.00705.x . PMID   15009096. S2CID   21813024.
• Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters. 481 (2): 147–51. doi: 10.1016/S0014-5793(00)01987-6 . PMID   10996314. S2CID   20831354.