CENPK

CENPK
Identifiers
Aliases	CENPK , AF5alpha, CENP-K, P33, Solt, FKSG14, centromere protein K
External IDs	OMIM: 611502 MGI: 1926210 HomoloGene: 11035 GeneCards: CENPK
Gene location (Human)
Chr.	Chromosome 5 (human)
End	65,563,168 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	104,252,392 bp
Gene ontology
Molecular function	• GO:0001948 protein binding ;
Cellular component	• cytosol ; • cell nucleus ; • nucleoplasm ; • condensed chromosome kinetochore ; • chromosome, centromeric region ; • chromosome ; • kinetochore ; • condensed nuclear chromosome inner kinetochore ;
Biological process	• CENP-A containing nucleosome assembly ; • kinetochore assembly ; • mitotic sister chromatid segregation ;
	Sources:Amigo / QuickGO
Orthologs
	64105
	60411
	ENSG00000123219
	ENSMUSG00000021714
	Q9BS16
	Q9ESN5
	NM_001267038 ; NM_022145 ; NM_001349367 ; NM_001349368 ; NM_001349369 Contents Interactions ; References ; External links ; Further reading ;
	NM_021790 ; NM_181061 ; NM_001377093 ; NM_001377094 ; NM_001377095
	NP_001253967 ; NP_071428 ; NP_001336296 ; NP_001336297 ; NP_001336298
	NP_068562 ; NP_851406 ; NP_001364022 ; NP_001364023 ; NP_001364024
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 09, 2020

Centromere protein K is a protein that in humans is encoded by the CENPK gene.^[5]^[6]

Interactions

CENPK has been shown to interact with SOX6.^[7]

Related Research Articles

Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene.

Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene.

Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.

Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.

Centromere protein U is a protein that in humans is encoded by the MLF1IP gene.

Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is encoded by the SRRT gene.

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.

Centromere protein H is a protein that in humans is encoded by the CENPH gene.

Pre-mRNA-splicing regulator WTAP is a protein that in humans is encoded by the WTAP gene.

Centromere protein I is a protein that in humans is encoded by the CENPI gene.

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.

SHC SH2 domain-binding protein 1 is a protein that in humans is encoded by the SHCBP1 gene.

Zinc finger CCCH domain-containing protein 13 is a protein that in humans is encoded by the ZC3H13 gene.

Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.

Centromere protein T is a protein that in humans is encoded by the CENPT gene.

Zinc finger protein 91 homolog is a protein that in humans is encoded by the ZFP91 gene.

Centromere protein O is a protein that in humans is encoded by the CENPO gene. CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced.

Nucleoporin 93 (Nup93) is a protein that in humans is encoded by the NUP93 gene.

Centromere protein N is a protein that in humans is encoded by the CENPN gene.

Centromere protein L is a protein that in humans is encoded by the CENPL gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000123219 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021714 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Taki T, Hayashi Y, Taniwaki M, Seto M, Ueda R, Hanada R, Suzukawa K, Yokota J, Morishita K (Nov 1996). "Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia". Oncogene. 13 (10): 2121–30. PMID 8950979.
↑ "Entrez Gene: CENPK centromere protein K".
↑ Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314. S2CID 20831354.

External links

Human CENPK genome location and CENPK gene details page in the UCSC Genome Browser .

Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (Jun 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197. S2CID 45931410.
Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314. S2CID 20831354.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000123219 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021714 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8950979-5] Taki T, Hayashi Y, Taniwaki M, Seto M, Ueda R, Hanada R, Suzukawa K, Yokota J, Morishita K (Nov 1996). "Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia". Oncogene. 13 (10): 2121–30. PMID 8950979.

[entrez-6] "Entrez Gene: CENPK centromere protein K".

[pmid10996314-7] Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314. S2CID 20831354.

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CENPK

Contents

Interactions

Related Research Articles

References

External links

Further reading