LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene. [5] [6] [7]
LHX3 encodes a protein of a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene. [7]
Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine. [7]
Homeobox expressed in ES cells 1, also known as homeobox protein ANF, is a homeobox protein that in humans is encoded by the HESX1 gene.
POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.
PDX1, also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. In vertebrates, Pdx1 is necessary for pancreatic development, including β-cell maturation, and duodenal differentiation. In humans this protein is encoded by the PDX1 gene, which was formerly known as IPF1. The gene was originally identified in the clawed frog Xenopus laevis and is present widely across the evolutionary diversity of bilaterian animals, although it has been lost in evolution in arthropods and nematodes. Despite the gene name being Pdx1, there is no Pdx2 gene in most animals; single-copy Pdx1 orthologs have been identified in all mammals. Coelacanth and cartilaginous fish are, so far, the only vertebrates shown to have two Pdx genes, Pdx1 and Pdx2.
Homeobox protein prophet of PIT-1 is a protein that in humans is encoded by the PROP1 gene.
LIM domain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene.
Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.
Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins.
Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene.
Paired mesoderm homeobox protein 2A is a protein that in humans is encoded by the PHOX2A gene.
Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.
Paired-like homeodomain 1 is a protein that in humans is encoded by the PITX1 gene.
Paired related homeobox 1 is a protein that in humans is encoded by the PRRX1 gene.
LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.
Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.
Visual system homeobox 2 is a protein that in humans is encoded by the VSX2 gene.
Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.
LIM homeobox 1 is a protein that in humans is encoded by the LHX1 gene. This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for control of differentiation and development of neural and lymphoid cells. It is also key in development of renal and urogenital systems and is required for normal organogenesis. A similar protein in mice is an essential regulator of the vertebrate head organizer.
Homeobox protein MOX-1 is a protein that in humans is encoded by the MEOX1 gene.
LIM/homeobox protein Lhx4 is a protein that in humans is encoded by the LHX4 gene.
LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.