ZMYND11

ZMYND11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NS5, 5HDA
Identifiers
Aliases	ZMYND11 , BRAM1, BS69, MRD30, zinc finger MYND-type containing 11
External IDs	OMIM: 608668; MGI: 1913755; HomoloGene: 4828; GeneCards: ZMYND11; OMA:ZMYND11 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10p15.3 Start 134,465 bp [1] End 254,637 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A1 Start 9,734,869 bp [2] End 9,815,366 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in optic nerve caput epididymis tail of epididymis corpus epididymis lactiferous duct inferior ganglion of vagus nerve corpus callosum superior vestibular nucleus postcentral gyrus Brodmann area 46 Top expressed in ciliary body retinal pigment epithelium iris barrel cortex conjunctival fornix ureter Region I of hippocampus proper substantia nigra Epithelium of choroid plexus medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding chromatin binding transcription coregulator activity metal ion binding protein binding transcription corepressor activity histone binding double-stranded DNA binding zinc ion binding methylated histone binding Cellular component nucleoplasm chromosome nucleus Biological process regulation of transcription, DNA-templated negative regulation of extrinsic apoptotic signaling pathway negative regulation of I-kappaB kinase/NF-kappaB signaling transcription, DNA-templated negative regulation of JNK cascade cell cycle cell population proliferation viral process regulation of transcription elongation from RNA polymerase II promoter defense response to virus negative regulation of nucleic acid-templated transcription chromatin organization negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10771 66505 Ensembl ENSG00000015171 ENSMUSG00000021156 UniProt Q15326 Q8R5C8 RefSeq (mRNA) NM_001202464 NM_001202465 NM_001202466 NM_001202467 NM_001202468 NM_006624 NM_212479 NM_001330057 NM_001199141 NM_144516 NM_001347470 NM_001347471 NM_001347472 NM_001347473 NM_001347474 NM_001347476 NM_001347477 NM_001347479 NM_001347480 NM_001347481 RefSeq (protein) NP_001189393 NP_001189394 NP_001189395 NP_001189396 NP_001189397 NP_001316986 NP_006615 NP_997644 NP_001357026 NP_001357027 NP_001357028 NP_001357029 NP_001357030 NP_001357031 NP_001357032 NP_001357033 NP_001357034 NP_001357035 NP_001357036 NP_001357037 NP_001357038 NP_001357039 NP_001357040 NP_001357041 NP_001357042 NP_001357043 NP_001357044 NP_001357045 NP_001357046 NP_001357047 NP_001357048 NP_001357049 NP_001357050 NP_001357051 NP_001357052 NP_001357053 NP_001186070 NP_001334399 NP_001334400 NP_001334401 NP_001334402 NP_001334403 NP_001334405 NP_001334406 NP_001334408 NP_001334409 NP_001334410 NP_653099 Location (UCSC) Chr 10: 0.13 – 0.25 Mb Chr 13: 9.73 – 9.82 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger MYND domain-containing protein 11 is a protein that in humans is encoded by the ZMYND11 gene. ^{[5] [6] [7]}

Function

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. ^[7]

Interactions

ZMYND11 has been shown to interact with:

• BMPR1A, ^[8]
• C11orf30, ^[9]
• ETS2, ^[10] and
• TAB1. ^[8]
• H3.3K36me3 ^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000015171 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021156 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hateboer G, Gennissen A, Ramos YF, Kerkhoven RM, Sonntag-Buck V, Stunnenberg HG, Bernards R (Jul 1995). "BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation". The EMBO Journal. 14 (13): 3159–69. doi:10.1002/j.1460-2075.1995.tb07318.x. PMC   394377 . PMID   7621829.
6. Masselink H, Bernards R (Mar 2000). "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR". Oncogene. 19 (12): 1538–46. doi: 10.1038/sj.onc.1203421 . PMID   10734313.
7. "Entrez Gene: ZMYND11 zinc finger, MYND domain containing 11".
8. Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (Apr 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes to Cells. 3 (4): 257–64. doi:10.1046/j.1365-2443.1998.00186.x. PMID   9663660. S2CID   29818690.
9. Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T (Nov 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–35. doi: 10.1016/s0092-8674(03)00930-9 . PMID   14651845. S2CID   18911371.
10. Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–8. PMID   12894593.
11. Wen, Hong; Li, Yuanyuan; Xi, Yuanxin; Jiang, Shiming; Stratton, Sabrina; Peng, Danni; Tanaka, Kaori; Ren, Yongfeng; Xia, Zheng; Wu, Jun; Li, Bing; Barton, Michelle C.; Li, Wei; Li, Haitao; Shi, Xiaobing (2014). "ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression". Nature. 508 (7495): 263–268. doi:10.1038/nature13045. PMC   4142212 . PMID   24590075.

Further reading

• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (Apr 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes to Cells. 3 (4): 257–64. doi:10.1046/j.1365-2443.1998.00186.x. PMID   9663660. S2CID   29818690.
• Lo KW, Naisbitt S, Fan JS, Sheng M, Zhang M (Apr 2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". The Journal of Biological Chemistry. 276 (17): 14059–66. doi: 10.1074/jbc.M010320200 . PMID   11148209.
• Ansieau S, Leutz A (Feb 2002). "The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif". The Journal of Biological Chemistry. 277 (7): 4906–10. doi: 10.1074/jbc.M110078200 . PMID   11733528.
• Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–8. PMID   12894593.
• Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T (Nov 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–35. doi: 10.1016/S0092-8674(03)00930-9 . PMID   14651845. S2CID   18911371.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Isobe T, Uchida C, Hattori T, Kitagawa K, Oda T, Kitagawa M (Jan 2006). "Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69". Biochemical and Biophysical Research Communications. 339 (1): 367–74. doi:10.1016/j.bbrc.2005.11.028. hdl: 10271/294 . PMID   16300738.
• Wan J, Zhang W, Wu L, Bai T, Zhang M, Lo KW, Chui YL, Cui Y, Tao Q, Yamamoto M, Akira S, Wu Z (Jan 2006). "BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway". Molecular and Cellular Biology. 26 (2): 448–56. doi:10.1128/MCB.26.2.448-456.2006. PMC   1346911 . PMID   16382137.
• Velasco G, Grkovic S, Ansieau S (Jun 2006). "New insights into BS69 functions". The Journal of Biological Chemistry. 281 (24): 16546–50. doi: 10.1074/jbc.M600573200 . PMID   16565076.