TAB1

Last updated
TAB1
Protein MAP3K7IP1 PDB 2j4o.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TAB1 , 3'-Tab1, MAP3K7IP1, TGF-beta activated kinase 1/MAP3K7 binding protein 1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1
External IDs OMIM: 602615; MGI: 1913763; HomoloGene: 4461; GeneCards: TAB1; OMA:TAB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153497
NM_006116

NM_025609

RefSeq (protein)

NP_006107
NP_705717

NP_079885

Location (UCSC) Chr 22: 39.4 – 39.44 Mb Chr 15: 80.02 – 80.05 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the TAB1 gene. [5] [6] [7]

Function

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta, interleukin-1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [7] TAB1 contains multiple amino acid sites that are phosphorylated and ubiquitinated. [8]

This protein plays an important role in skin homeostasis, [9] [10] wound repair, [11] [12] and oncogenesis. [13]

Interactions

TAB1 has been shown to interact with:

Related Research Articles

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Further reading