TAB1

TAB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2J4O, 2POM, 2POP, 2YDS, 2YIY, 4AY5, 4AY6, 4GS6, 4KA3, 4L3P, 4L53, 4O91, 5DIY, 5JGA, 5JGD
Identifiers
Aliases	TAB1 , 3'-Tab1, MAP3K7IP1, TGF-beta activated kinase 1/MAP3K7 binding protein 1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1
External IDs	OMIM: 602615 MGI: 1913763 HomoloGene: 4461 GeneCards: TAB1
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.1 Start 39,399,778 bp [1] End 39,437,060 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 80,133,127 bp [2] End 80,161,707 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein serine/threonine phosphatase activity • GO:0001948 protein binding • catalytic activity • kinase activator activity • GO:0010577 enzyme activator activity • GO:0032403 protein-containing complex binding • mitogen-activated protein kinase p38 binding • protein kinase activator activity Cellular component • endosome membrane • cytosol • nuclear speck • protein-containing complex • nucleus Biological process • cardiac septum development • lung development • protein dephosphorylation • heart morphogenesis • stimulatory C-type lectin receptor signaling pathway • in utero embryonic development • MyD88-dependent toll-like receptor signaling pathway • coronary vasculature development • Fc-epsilon receptor signaling pathway • JNK cascade • aorta development • positive regulation of NF-kappaB transcription factor activity • I-kappaB kinase/NF-kappaB signaling • transforming growth factor beta receptor signaling pathway • nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of MAP kinase activity • protein deubiquitination • interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10454	66513
Ensembl	ENSG00000100324	ENSMUSG00000022414
UniProt	Q15750	Q8CF89
RefSeq (mRNA)	NM_153497 NM_006116	NM_025609
RefSeq (protein)	NP_006107 NP_705717	NP_079885
Location (UCSC)	Chr 22: 39.4 – 39.44 Mb	Chr 15: 80.13 – 80.16 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the TAB1 gene. ^{[5] [6] [7]}

Function

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta, interleukin-1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. ^[7] TAB1 contains multiple amino acid sites that are phosphorylated and ubiquitinated. ^[8]

This protein plays an important role in skin homeostasis, ^{[9] [10]} wound repair, ^{[11] [12]} and oncogenesis. ^[13]

Interactions

TAB1 has been shown to interact with:

• MAP3K7IP2, ^{[14] [15] [16]}
• MAP3K7IP3, ^[16]
• MAP3K7, ^{[16] [17] [18] [19]}
• MAP3K1, ^[20]
• MAPK14, ^[21]
• Mothers against decapentaplegic homolog 7, ^{[22] [23]}
• TRAF6, ^{[14] [17] [24]}
• XIAP, ^{[25] [26]} and
• ZMYND11. ^[27]

References

1. GRCh38: Ensembl release 89: ENSG00000100324 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022414 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K (July 1996). "TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction". Science. 272 (5265): 1179–82. Bibcode:1996Sci...272.1179S. doi:10.1126/science.272.5265.1179. PMID   8638164. S2CID   84807994.
6. Sakurai H, Miyoshi H, Toriumi W, Sugita T (May 1999). "Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation". J Biol Chem. 274 (15): 10641–8. doi: 10.1074/jbc.274.15.10641 . PMID   10187861.
7. "Entrez Gene: MAP3K7IP1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1".
8. "TAB1 (human)". www.phosphosite.org. Retrieved 2020-10-31.
9. Omori E, Matsumoto K, Sanjo H, Sato S, Akira S, Smart RC, Ninomiya-Tsuji J (July 2006). "TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis". J. Biol. Chem. 281 (28): 19610–19617. doi: 10.1074/jbc.M603384200 . PMC   1797070 . PMID   16675448.
10. Sayama K, Hanakawa Y, Nagai H, Shirakata Y, Dai X, Hirakawa S, Tokumaru S, Tohyama M, Yang L, Sato S, Shizuo A, Hashimoto K (August 2006). "Transforming growth factor-beta-activated kinase 1 is essential for differentiation and the prevention of apoptosis in epidermis". J. Biol. Chem. 281 (31): 22013–22020. doi: 10.1074/jbc.M601065200 . PMID   16754690.
11. Tan SH, Pal M, Tan MJ, Wong MH, Tam FU, Teo JW, Chong HC, Tan CK, Goh YY, Tang MB, Cheung PC, Tan NS (July 2009). "Regulation of cell proliferation and migration by TAK1 via transcriptional control of von Hippel-Lindau tumor suppressor". J. Biol. Chem. 284 (27): 18047–18058. doi: 10.1074/jbc.M109.002691 . PMC   2709347 . PMID   19419968.
12. Lam CR, Tan MJ, Tan SH, Tang MB, Cheung PC, Tan NS (January 2011). "TAK1 regulates SCF expression to modulate PKBα activity that protects keratinocytes from ROS-induced apoptosis". Cell Death Differ. 18 (7): 1120–9. doi:10.1038/cdd.2010.182. PMC   3131962 . PMID   21233843.
13. Omori E, Matsumoto K, Zhu S, Smart RC, Ninomiya-Tsuji J (November 2010). "Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells". Cancer Res. 70 (21): 8417–8425. doi:10.1158/0008-5472.CAN-10-1227. PMC   2970664 . PMID   20959492.
14. Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K (April 2000). "TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway". Mol. Cell. 5 (4): 649–58. doi: 10.1016/s1097-2765(00)80244-0 . PMID   10882101.
15. Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
16. Cheung PC, Nebreda AR, Cohen P (February 2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem. J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC   1223947 . PMID   14670075.
17. Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (March 1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature. 398 (6724): 252–6. Bibcode:1999Natur.398..252N. doi:10.1038/18465. PMID   10094049. S2CID   4421236.
18. Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL, Zhang Y (November 2003). "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling". J. Biol. Chem. 278 (47): 47089–97. doi: 10.1074/jbc.M306002200 . PMID   12975377.
19. Sakurai H, Miyoshi H, Mizukami J, Sugita T (June 2000). "Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1". FEBS Lett. 474 (2–3): 141–5. doi: 10.1016/s0014-5793(00)01588-x . PMID   10838074.
20. Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E (November 2014). "The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines". The EMBO Journal. 33 (21): 2581–96. doi:10.15252/embj.201488351. PMC   4282369 . PMID   25260751.
21. Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J (February 2002). "MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha". Science. 295 (5558): 1291–4. Bibcode:2002Sci...295.1291G. doi:10.1126/science.1067289. PMID   11847341. S2CID   93896233.
22. Edlund S, Bu S, Schuster N, Aspenström P, Heuchel R, Heldin NE, ten Dijke P, Heldin CH, Landström M (February 2003). "Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3". Mol. Biol. Cell. 14 (2): 529–44. doi:10.1091/mbc.02-03-0037. PMC   149990 . PMID   12589052.
23. Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T (December 2001). "Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7". Genes Cells. 6 (12): 1091–9. doi: 10.1046/j.1365-2443.2001.00483.x . PMID   11737269.
24. Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y (2008). Unutmaz D (ed.). "TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL". PLOS ONE. 3 (12): e4064. Bibcode:2008PLoSO...3.4064W. doi: 10.1371/journal.pone.0004064 . PMC   2603309 . PMID   19112497.
25. Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K (January 1999). "XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway". EMBO J. 18 (1): 179–87. doi:10.1093/emboj/18.1.179. PMC   1171113 . PMID   9878061.
26. Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ (August 2002). "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis". J. Biol. Chem. 277 (34): 30454–62. doi: 10.1074/jbc.M203312200 . PMID   12048196.
27. Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (April 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes Cells. 3 (4): 257–64. doi:10.1046/j.1365-2443.1998.00186.x. PMID   9663660. S2CID   29818690.

Further reading

• Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes Cells. 3 (4): 257–64. doi:10.1046/j.1365-2443.1998.00186.x. PMID   9663660. S2CID   29818690.
• Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K (1999). "XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway". EMBO J. 18 (1): 179–87. doi:10.1093/emboj/18.1.179. PMC   1171113 . PMID   9878061.
• Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature. 398 (6724): 252–6. Bibcode:1999Natur.398..252N. doi:10.1038/18465. PMID   10094049. S2CID   4421236.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Kishimoto K, Matsumoto K, Ninomiya-Tsuji J (2000). "TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop". J. Biol. Chem. 275 (10): 7359–64. doi: 10.1074/jbc.275.10.7359 . PMID   10702308.
• Sakurai H, Miyoshi H, Mizukami J, Sugita T (2000). "Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1". FEBS Lett. 474 (2–3): 141–5. doi: 10.1016/S0014-5793(00)01588-X . PMID   10838074.
• Ono K, Ohtomo T, Sato S, Sugamata Y, Suzuki M, Hisamoto N, Ninomiya-Tsuji J, Tsuchiya M, Matsumoto K (2001). "An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK". J. Biol. Chem. 276 (26): 24396–400. doi: 10.1074/jbc.M102631200 . PMID   11323434.
• Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X (2001). "IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B." J. Biol. Chem. 276 (45): 41661–7. doi: 10.1074/jbc.M102262200 . PMID   11518704.
• Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T (2002). "Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7". Genes Cells. 6 (12): 1091–9. doi: 10.1046/j.1365-2443.2001.00483.x . PMID   11737269.
• Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J (2002). "MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha". Science. 295 (5558): 1291–4. Bibcode:2002Sci...295.1291G. doi:10.1126/science.1067289. PMID   11847341. S2CID   93896233.
• Sakurai H, Nishi A, Sato N, Mizukami J, Miyoshi H, Sugita T (2002). "TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways". Biochem. Biophys. Res. Commun. 297 (5): 1277–81. doi:10.1016/S0006-291X(02)02379-3. PMID   12372426.
• Ge B, Xiong X, Jing Q, Mosley JL, Filose A, Bian D, Huang S, Han J (2003). "TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1". J. Biol. Chem. 278 (4): 2286–93. doi: 10.1074/jbc.M210918200 . PMID   12429732.
• Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K (2003). "The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling". Mol. Cell. Biol. 23 (1): 131–9. doi:10.1128/MCB.23.1.131-139.2003. PMC   140665 . PMID   12482967.
• Suzawa M, Takada I, Yanagisawa J, Ohtake F, Ogawa S, Yamauchi T, Kadowaki T, Takeuchi Y, Shibuya H, Gotoh Y, Matsumoto K, Kato S (2003). "Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade". Nat. Cell Biol. 5 (3): 224–30. doi:10.1038/ncb942. PMID   12598905. S2CID   114603.
• Tanno M, Bassi R, Gorog DA, Saurin AT, Jiang J, Heads RJ, Martin JL, Davis RJ, Flavell RA, Marber MS (2003). "Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia". Circ. Res. 93 (3): 254–61. doi: 10.1161/01.RES.0000083490.43943.85 . PMID   12829618.
• Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL, Zhang Y (2004). "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling". J. Biol. Chem. 278 (47): 47089–97. doi: 10.1074/jbc.M306002200 . PMID   12975377.
• Cheung PC, Nebreda AR, Cohen P (2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem. J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC   1223947 . PMID   14670075.