YWHAB

YWHAB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BQ0, 2C23, 4DNK
Identifiers
Aliases	YWHAB , GW128, HEL-S-1, HS1, KCIP-1, YWHAA, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
External IDs	OMIM: 601289 MGI: 1891917 HomoloGene: 20724 GeneCards: YWHAB
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.12 Start 44,885,702 bp [1] End 44,908,532 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H3 Start 163,836,880 bp [2] End 163,860,508 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus entorhinal cortex parietal lobe postcentral gyrus pons superior frontal gyrus superior vestibular nucleus visceral pleura Top expressed in substantia nigra ventromedial nucleus external carotid artery internal carotid artery motor neuron saccule facial motor nucleus barrel cortex dorsomedial hypothalamic nucleus Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity protein domain specific binding protein-containing complex binding histone deacetylase binding phosphoprotein binding protein C-terminus binding protein binding enzyme binding phosphoserine residue binding cadherin binding identical protein binding Cellular component cytoplasm membrane focal adhesion melanosome transcription repressor complex perinuclear region of cytoplasm extracellular exosome cytoplasmic vesicle membrane nucleus mitochondrion cytosol protein-containing complex vacuole vacuolar membrane Biological process protein targeting negative regulation of protein dephosphorylation protein heterooligomerization regulation of mRNA stability positive regulation of catalytic activity hippo signaling cytoplasmic sequestering of protein MAPK cascade positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway membrane organization viral process negative regulation of transcription, DNA-templated negative regulation of G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7529 54401 Ensembl ENSG00000166913 ENSMUSG00000018326 UniProt P31946 Q4VY19 Q9CQV8 RefSeq (mRNA) NM_139323 NM_003404 NM_018753 RefSeq (protein) NP_003395 NP_647539 NP_061223 Location (UCSC) Chr 20: 44.89 – 44.91 Mb Chr 2: 163.84 – 163.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

14-3-3 protein beta/alpha is a protein that in humans is encoded by the YWHAB gene. ^[5]

Function

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. ^[6]

Interactions

YWHAB has been shown to interact with:

• BRAF, ^{[7] [8]}
• C-Raf, ^{[9] [10] [11] [12] [13] [14]}
• CD29, ^[15]
• CDC25A, ^[9]
• CDC25B, ^{[9] [16]}
• Cbl gene, ^[17]
• EPB41L3, ^{[7] [18]}
• HDAC4 ^[19]
• KCNK3, ^[20]
• MAPK7, ^[21]
• PTPN3, ^[22]
• PRKCZ, ^[12]
• RPS6KA1, ^[23]
• TESK1, ^[24]
• TNFAIP3, ^[14] and
• WEE1. ^[25]

See also

• 14-3-3 proteins

References

1. GRCh38: Ensembl release 89: ENSG00000166913 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018326 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tommerup N, Leffers H (June 1996). "Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization". Genomics. 33 (1): 149–50. doi:10.1006/geno.1996.0176. PMID   8617504.
6. "Entrez Gene: YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide".
7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
8. Qiu W, Zhuang S, von Lintig FC, Boss GR, Pilz RB (October 2000). "Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins". J. Biol. Chem. 275 (41): 31921–9. doi: 10.1074/jbc.M003327200 . PMID   10931830.
9. Conklin DS, Galaktionov K, Beach D (August 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7892–6. doi: 10.1073/pnas.92.17.7892 . PMC   41252 . PMID   7644510.
10. Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID   12620389.
11. Truong AB, Masters SC, Yang H, Fu H (November 2002). "Role of the 14-3-3 C-terminal loop in ligand interaction". Proteins. 49 (3): 321–5. doi:10.1002/prot.10210. PMID   12360521. S2CID   31480274.
12. Van Der Hoeven PC, Van Der Wal JC, Ruurs P, Van Dijk MC, Van Blitterswijk J (January 2000). "14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation". Biochem. J. 345 (2): 297–306. doi:10.1042/0264-6021:3450297. PMC   1220759 . PMID   10620507.
13. Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (July 2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC   85938 . PMID   10848612.
14. Vincenz C, Dixit VM (August 1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". J. Biol. Chem. 271 (33): 20029–34. doi: 10.1074/jbc.271.33.20029 . PMID   8702721.
15. Han DC, Rodriguez LG, Guan JL (January 2001). "Identification of a novel interaction between integrin beta1 and 14-3-3beta". Oncogene. 20 (3): 346–57. doi: 10.1038/sj.onc.1204068 . PMID   11313964.
16. Mils V, Baldin V, Goubin F, Pinta I, Papin C, Waye M, Eychene A, Ducommun B (March 2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10): 1257–65. doi: 10.1038/sj.onc.1203419 . PMID   10713667.
17. Robertson H, Langdon WY, Thien CB, Bowtell DD (November 1997). "A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components". Biochem. Biophys. Res. Commun. 240 (1): 46–50. doi:10.1006/bbrc.1997.7608. PMID   9367879.
18. Yu T, Robb VA, Singh V, Gutmann DH, Newsham IF (August 2002). "The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins". Biochem. J. 365 (Pt 3): 783–9. doi:10.1042/BJ20020060. PMC   1222735 . PMID   11996670.
19. Grozinger CM, Schreiber SL (July 2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7835–40. doi: 10.1073/pnas.140199597 . PMC   16631 . PMID   10869435.
20. O'Kelly I, Butler MH, Zilberberg N, Goldstein SA (November 2002). "Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals". Cell. 111 (4): 577–88. doi: 10.1016/S0092-8674(02)01040-1 . PMID   12437930. S2CID   15898814.
21. Zheng Q, Yin G, Yan C, Cavet M, Berk BC (March 2004). "14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function". J. Biol. Chem. 279 (10): 8787–91. doi: 10.1074/jbc.M310212200 . PMID   14679215.
22. Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK (October 1997). "Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein". J. Biol. Chem. 272 (43): 27281–7. doi: 10.1074/jbc.272.43.27281 . PMID   9341175.
23. Cavet ME, Lehoux S, Berk BC (May 2003). "14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity". J. Biol. Chem. 278 (20): 18376–83. doi: 10.1074/jbc.M208475200 . PMID   12618428.
24. Toshima JY, Toshima J, Watanabe T, Mizuno K (November 2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". J. Biol. Chem. 276 (46): 43471–81. doi: 10.1074/jbc.M104620200 . PMID   11555644.
25. Wang Y, Jacobs C, Hook KE, Duan H, Booher RN, Sun Y (April 2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. 11 (4): 211–9. PMID   10775038.

Further reading

• Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID   15142377.
• Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. doi:10.1196/annals.1321.013. PMID   15265780. S2CID   23655886.
• Calinisan V, Gravem D, Chen RP, Brittin S, Mohandas N, Lecomte MC, Gascard P (2006). "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium". Front. Biosci. 11: 1646–66. doi: 10.2741/1911 . PMID   16368544. S2CID   26325962.