KCNK3

Last updated
KCNK3
KCNK3.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KCNK3 , K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1, potassium two pore domain channel subfamily K member 3, TASK1
External IDs OMIM: 603220; MGI: 1100509; HomoloGene: 1692; GeneCards: KCNK3; OMA:KCNK3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002246

NM_010608

RefSeq (protein)

NP_002237

NP_034738

Location (UCSC) Chr 2: 26.69 – 26.73 Mb Chr 5: 30.75 – 30.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium channel subfamily K member 3 is a protein that in humans is encoded by the KCNK3 gene. [5] [6] [7] [8]

Contents

This gene encodes K2P3.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P3.1 is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Nicotine Activity on Dopaminergic Neurons edit
  1. The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

Interactions

KCNK3 has been shown to interact with YWHAB [9] and S100A10. [10]

See also

Related Research Articles

<span class="mw-page-title-main">Two-pore-domain potassium channel</span> Class of transport proteins

The two-pore-domain or tandem pore domain potassium channels are a family of 15 members that form what is known as leak channels which possess Goldman-Hodgkin-Katz (open) rectification. These channels are regulated by several mechanisms including signaling lipids, oxygen tension, pH, mechanical stretch, and G-proteins. Two-pore-domain potassium channels correspond structurally to a inward-rectifier potassium channel α-subunits. Each inward-rectifier potassium channel α-subunit is composed of two transmembrane α-helices, a pore helix and a potassium ion selectivity filter sequence and assembles into a tetramer forming the complete channel. The two-pore domain potassium channels instead are dimers where each subunit is essentially two α-subunits joined together.

<span class="mw-page-title-main">KCNK2</span> Protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 2, also known as TREK-1, is a protein that in humans is encoded by the KCNK2 gene.

<span class="mw-page-title-main">KCNQ4</span> Mammalian protein found in Homo sapiens

Potassium voltage-gated channel subfamily KQT member 4, also known as voltage-gated potassium channel subunit Kv7.4, is a protein that in humans is encoded by the KCNQ4 gene.

<span class="mw-page-title-main">KCNK1</span> Protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.

<span class="mw-page-title-main">KCNK9</span> Protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 9 is a protein that in humans is encoded by the KCNK9 gene.

<span class="mw-page-title-main">KCNK4</span> Protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 4 is a protein that in humans is encoded by the KCNK4 gene. KCNK4 protein channels are also called TRAAK channels.

<span class="mw-page-title-main">KCNK6</span> Protein-coding gene in humans

Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene.

<span class="mw-page-title-main">KCNK5</span> Protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene.

<span class="mw-page-title-main">KCNJ9</span> Protein-coding gene in the species Homo sapiens

G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene.

<span class="mw-page-title-main">KCNK15</span> Protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 15 is a protein that in humans is encoded by the KCNK15 gene.

<span class="mw-page-title-main">KCNK17</span> Protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 17 is a protein that in humans is encoded by the KCNK17 gene.

<span class="mw-page-title-main">KCNA10</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily A member 10 also known as Kv1.8 is a protein that in humans is encoded by the KCNA10 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNH3</span> Protein-coding gene in humans

Potassium voltage-gated channel subfamily H member 3 is a protein that in humans is encoded by the KCNH3 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNH4</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily H member 4 is a protein, that in humans, is encoded by the KCNH4 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNK7</span> Protein-coding gene in the species Homo sapiens

Potassium channel, subfamily K, member 7, also known as KCNK7 or K2P7.1 is a protein which is encoded in humans by the KCNK7 gene. K2P7.1 is a potassium channel containing two pore-forming P domains. Multiple transcript variants encoding different isoforms have been found for this gene.

<span class="mw-page-title-main">KCNK10</span> Protein-coding gene in the species Homo sapiens

Potassium channel, subfamily K, member 10, also known as KCNK10 is a human gene. The protein encoded by this gene, K2P10.1, is a potassium channel containing two pore-forming P domains.

<span class="mw-page-title-main">KCNK12</span> Protein-coding gene in the species Homo sapiens

Potassium channel, subfamily K, member 12, also known as KCNK12 is a human gene. The protein encoded by this gene, K2P12.1, is a potassium channel containing two pore-forming P domains.

<span class="mw-page-title-main">KCNK13</span> Protein-coding gene in the species Homo sapiens

Potassium channel, subfamily K, member 13, also known as KCNK13 is a human gene. The protein encoded by this gene, K2P13.1 is a potassium channel containing two pore-forming P domains.

<span class="mw-page-title-main">KCNK16</span> Protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 16 is a protein that in humans is encoded by the KCNK16 gene. The protein encoded by this gene, K2P16.1, is a potassium channel containing two pore-forming P domains.

A potassium channel opener is a type of drug which facilitates ion transmission through potassium channels.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171303 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049265 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M (Dec 1997). "TASK, a human background K+ channel to sense external pH variations near physiological pH". EMBO J. 16 (17): 5464–71. doi:10.1093/emboj/16.17.5464. PMC   1170177 . PMID   9312005.
  6. Lesage F, Lazdunski M (Oct 1998). "Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23". Genomics. 51 (3): 478–9. doi:10.1006/geno.1998.5397. PMID   9721223.
  7. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID   16382106. S2CID   7356601.
  8. 1 2 "Entrez Gene: KCNK3 potassium channel, subfamily K, member 3".
  9. O'Kelly, Ita; Butler Margaret H; Zilberberg Noam; Goldstein Steve A N (Nov 2002). "Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals". Cell. 111 (4). United States: 577–88. doi: 10.1016/S0092-8674(02)01040-1 . ISSN   0092-8674. PMID   12437930. S2CID   15898814.
  10. Girard, Christophe; Tinel Norbert; Terrenoire Cécile; Romey Georges; Lazdunski Michel; Borsotto Marc (Sep 2002). "p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1". EMBO J. 21 (17). England: 4439–48. doi:10.1093/emboj/cdf469. ISSN   0261-4189. PMC   125412 . PMID   12198146.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.