KCNK3

KCNK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 6RV2, 6RV3, 6RV4
Identifiers
Aliases	KCNK3 , K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1, potassium two pore domain channel subfamily K member 3, TASK1
External IDs	OMIM: 603220; MGI: 1100509; HomoloGene: 1692; GeneCards: KCNK3; OMA:KCNK3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p23.3 Start 26,692,722 bp [1] End 26,733,420 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 B1|5 16.68 cM Start 30,745,514 bp [2] End 30,782,615 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left adrenal gland adrenal cortex left adrenal cortex right adrenal cortex beta cell lower lobe of lung right lung paraflocculus of cerebellum pons upper lobe of lung Top expressed in adrenal gland lobe of prostate brown adipose tissue myocardium of ventricle right ventricle cerebellar cortex facial motor nucleus lobe of cerebellum cardiac muscles tunica adventitia of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function S100 protein binding potassium channel activity protein homodimerization activity open rectifier potassium channel activity potassium ion leak channel activity ion channel activity protein heterodimerization activity growth factor activity protein C-terminus binding protein binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular space Biological process cochlea development ion transport cellular response to zinc ion potassium ion transport ion transmembrane transport brain development cardiac conduction potassium ion transmembrane transport cellular response to hypoxia negative regulation of cytosolic calcium ion concentration chemical synaptic transmission stabilization of membrane potential regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3777 16527 Ensembl ENSG00000171303 ENSMUSG00000049265 UniProt O14649 O35111 RefSeq (mRNA) NM_002246 NM_010608 RefSeq (protein) NP_002237 NP_034738 Location (UCSC) Chr 2: 26.69 – 26.73 Mb Chr 5: 30.75 – 30.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium channel subfamily K member 3 is a protein that in humans is encoded by the KCNK3 gene. ^{[5] [6] [7] [8]}

This gene encodes K_2P3.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P3.1 is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. ^[8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

1. The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

Interactions

KCNK3 has been shown to interact with YWHAB ^[9] and S100A10. ^[10]

See also

• Tandem pore domain potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000171303 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049265 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M (Dec 1997). "TASK, a human background K+ channel to sense external pH variations near physiological pH". EMBO J. 16 (17): 5464–71. doi:10.1093/emboj/16.17.5464. PMC   1170177 . PMID   9312005.
6. Lesage F, Lazdunski M (Oct 1998). "Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23". Genomics. 51 (3): 478–9. doi:10.1006/geno.1998.5397. PMID   9721223.
7. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID   16382106. S2CID   7356601.
8. "Entrez Gene: KCNK3 potassium channel, subfamily K, member 3".
9. O'Kelly, Ita; Butler Margaret H; Zilberberg Noam; Goldstein Steve A N (Nov 2002). "Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals". Cell. 111 (4). United States: 577–88. doi: 10.1016/S0092-8674(02)01040-1 . ISSN   0092-8674. PMID   12437930. S2CID   15898814.
10. Girard, Christophe; Tinel Norbert; Terrenoire Cécile; Romey Georges; Lazdunski Michel; Borsotto Marc (Sep 2002). "p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1". EMBO J. 21 (17). England: 4439–48. doi:10.1093/emboj/cdf469. ISSN   0261-4189. PMC   125412 . PMID   12198146.

Further reading

• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID   11256078. S2CID   9682396.
• Patel AJ, Honoré E, Lesage F, et al. (1999). "Inhalational anesthetics activate two-pore-domain background K+ channels". Nat. Neurosci. 2 (5): 422–6. doi:10.1038/8084. PMID   10321245. S2CID   23092576.
• Manjunath NA, Bray-Ward P, Goldstein SA, Gallagher PG (2000). "Assignment of the 2P domain, acid-sensitive potassium channel OAT1 gene KCNK3 to human chromosome bands 2p24.1→p23.3 and murine 5B by in situ hybridization". Cytogenet. Cell Genet. 86 (3–4): 242–3. doi:10.1159/000015349. PMID   10575216. S2CID   9629583.
• Lopes CM, Gallagher PG, Buck ME, et al. (2000). "Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3". J. Biol. Chem. 275 (22): 16969–78. doi: 10.1074/jbc.M001948200 . PMID   10748056.
• Ashmole I, Goodwin PA, Stanfield PR (2002). "TASK-5, a novel member of the tandem pore K+ channel family". Pflügers Arch. 442 (6): 828–33. doi:10.1007/s004240100620. PMID   11680614. S2CID   27704471.
• Talley EM, Bayliss DA (2002). "Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action". J. Biol. Chem. 277 (20): 17733–42. doi: 10.1074/jbc.M200502200 . PMID   11886861.
• Buist SC, Cherrington NJ, Choudhuri S, et al. (2002). "Gender-specific and developmental influences on the expression of rat organic anion transporters". J. Pharmacol. Exp. Ther. 301 (1): 145–51. doi:10.1124/jpet.301.1.145. PMID   11907168.
• Barbuti A, Ishii S, Shimizu T, et al. (2002). "Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor". Am. J. Physiol. Heart Circ. Physiol. 282 (6): H2024–30. doi:10.1152/ajpheart.00956.2001. PMID   12003807.
• Girard C, Tinel N, Terrenoire C, et al. (2002). "p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1". EMBO J. 21 (17): 4439–48. doi:10.1093/emboj/cdf469. PMC   125412 . PMID   12198146.
• O'Kelly I, Butler MH, Zilberberg N, Goldstein SA (2002). "Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals". Cell. 111 (4): 577–88. doi: 10.1016/S0092-8674(02)01040-1 . PMID   12437930. S2CID   15898814.
• Aslamkhan A, Han YH, Walden R, et al. (2003). "Stoichiometry of organic anion/dicarboxylate exchange in membrane vesicles from rat renal cortex and hOAT1-expressing cells". Am. J. Physiol. Renal Physiol. 285 (4): F775–83. doi:10.1152/ajprenal.00140.2003. PMID   12837685.
• Strebel K (2004). "HIV-1 Vpu: putting a channel to the TASK". Mol. Cell. 14 (2): 150–2. doi: 10.1016/S1097-2765(04)00205-9 . PMID   15099514.
• Hsu K, Seharaseyon J, Dong P, et al. (2004). "Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel". Mol. Cell. 14 (2): 259–67. doi: 10.1016/S1097-2765(04)00183-2 . PMID   15099524.
• Rusznák Z, Pocsai K, Kovács I, et al. (2004). "Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum". Cell. Mol. Life Sci. 61 (12): 1532–42. doi:10.1007/s00018-004-4082-3. PMC   11138546 . PMID   15197476. S2CID   11439105.
• Bai X, Greenwood SL, Glazier JD, et al. (2005). "Localization of TASK and TREK, two-pore domain K+ channels, in human cytotrophoblast cells". J. Soc. Gynecol. Investig. 12 (2): 77–83. doi:10.1016/j.jsgi.2004.08.004. PMID   15695101. S2CID   20173840.

External links

• KCNK3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.