KCNQ5

KCNQ5
Identifiers
Aliases	KCNQ5 , Kv7.5, potassium voltage-gated channel subfamily Q member 5, MRD46
External IDs	OMIM: 607357 MGI: 1924937 HomoloGene: 28270 GeneCards: KCNQ5
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q13 Start 72,621,792 bp [1] End 73,198,853 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 A4 Start 21,468,627 bp [2] End 22,032,166 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell pons Brodmann area 23 tibialis anterior muscle deltoid muscle quadriceps femoris muscle Brodmann area 46 vastus lateralis muscle superior frontal gyrus middle temporal gyrus Top expressed in primary motor cortex olfactory tubercle nucleus accumbens piriform cortex sternocleidomastoid muscle prefrontal cortex temporal muscle globus pallidus digastric muscle temporal lobe More reference expression data BioGPS n/a
Gene ontology Molecular function ion channel activity potassium channel activity protein binding voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity calmodulin binding Cellular component membrane clathrin coat integral component of membrane integral component of plasma membrane voltage-gated potassium channel complex plasma membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport transmembrane transport potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56479 226922 Ensembl ENSG00000185760 ENSMUSG00000028033 UniProt Q9NR82 Q9JK45 RefSeq (mRNA) NM_001160130 NM_001160132 NM_001160133 NM_001160134 NM_019842 NM_001160139 NM_023872 NM_001310477 RefSeq (protein) NP_001153602 NP_001153604 NP_001153605 NP_001153606 NP_062816 NP_001153611 NP_001297406 NP_076361 Location (UCSC) Chr 6: 72.62 – 73.2 Mb Chr 1: 21.47 – 22.03 Mb PubMed search [3] [4]
Wikidata
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Potassium voltage-gated channel subfamily KQT member 5 is a protein that in humans is encoded by the KCNQ5 gene. ^{[5] [6] [7] [8]}

This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of only one has been determined. ^[8]

Interactions

KCNQ5 has been shown to interact with KvLQT3. ^[9]

See also

• Voltage-gated potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000185760 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028033 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K (Aug 2000). "Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity". J Biol Chem. 275 (29): 22395–400. doi: 10.1074/jbc.M002378200 . PMID   10787416.
6. Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ (Sep 2000). "KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents". J Biol Chem. 275 (31): 24089–95. doi: 10.1074/jbc.M003245200 . PMID   10816588.
7. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.
8. "Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5".
9. Yus-Nájera, E; Muñoz A; Salvador N; Jensen B S; Rasmussen H B; Defelipe J; Villarroel A (2003). "Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation". Neuroscience. 120 (2): 353–64. doi:10.1016/S0306-4522(03)00321-X. ISSN   0306-4522. PMID   12890507. S2CID   38381189.

Further reading

• Wickenden AD, Zou A, Wagoner PK, Jegla T (2001). "Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells". Br. J. Pharmacol. 132 (2): 381–4. doi:10.1038/sj.bjp.0703861. PMC   1572592 . PMID   11159685.
• Yus-Najera E, Santana-Castro I, Villarroel A (2002). "The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels". J. Biol. Chem. 277 (32): 28545–53. doi: 10.1074/jbc.M204130200 . PMID   12032157.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ozeki Y, Tomoda T, Kleiderlein J, et al. (2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 289–94. Bibcode:2003PNAS..100..289O. doi: 10.1073/pnas.0136913100 . PMC   140954 . PMID   12506198.
• Yus-Nájera E, Muñoz A, Salvador N, et al. (2003). "Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation". Neuroscience. 120 (2): 353–64. doi:10.1016/S0306-4522(03)00321-X. PMID   12890507. S2CID   38381189.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Li Y, Langlais P, Gamper N, et al. (2004). "Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase". J. Biol. Chem. 279 (44): 45399–407. doi: 10.1074/jbc.M408410200 . PMID   15304482.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Jensen HS, Grunnet M, Olesen SP (2007). "Inactivation as a new regulatory mechanism for neuronal Kv7 channels". Biophys. J. 92 (8): 2747–56. Bibcode:2007BpJ....92.2747J. doi:10.1529/biophysj.106.101287. PMC   1831682 . PMID   17237198.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.